The protein composition of the fibrinoid material at the human uteroplacental interface

Sutcliffe, R.; Davies, Malcolm; Hunter, Jean B.; Waters, J.J.; Parry, J.E.

doi:10.1016/s0143-4004(82)80006-4

Cited by 22 publications

(3 citation statements)

References 27 publications

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“…Fibrinoid layers in the placental basal plate may play a role in the barrier that protects fetal antigens from being identified by maternal cells [25]. Sutcliffe et al [28] reported the presence of ample fibrinoid layers in human and rodent placentas with invasive implantation relative to other mammals by noninvasive implantation with largely intact maternal and fetal epithelial surfaces facing each other. Based on these findings, it was suggested that changes in the thickness of Rohr fibrinoid layer might be associated with a fetomaternal immunoreaction or the situation of implantation.…”

Section: Discussionmentioning

confidence: 99%

Morphologic characteristics of the placental basal plate in in vitro fertilization pregnancies: a possible association with the amount of bleeding in delivery

et al. 2015

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The aim of the present study was to investigate the relationship between assisted reproductive technology procedures, the morphology of the basal plate of placentas, and amount of bleeding in deliveries. Fifty-five whole placentas (fresh-embryo transfer in the in vitro fertilization cycle [n = 6], frozen-thawed embryo transfer in the natural cycle [n = 13] or in the hormonal cycle [n = 10], and age-matched spontaneously conceived pregnancies [n = 26]) were retrospectively enrolled and histologically analyzed. The whole placentas were stored in our pathological division among 512 singleton pregnancies with vaginal deliveries (34-41 weeks of gestation) at Hamamatsu University Hospital. The morphology of the placental basal plate was examined using Azan staining. A total of 20 digital images (each 0.53 mm(2)) of microscopic fields were analyzed per placenta to measure the mean values of the vertical maximum thickness of Rohr and Nitabuch fibrinoid layers and % loss of decidua. The thickness of Rohr fibrinoid layer and % loss of decidua were significantly higher in the frozen-thawed embryo transfer in the hormonal cycle group than in the frozen-thawed embryo transfer in the natural cycle and spontaneously conceived pregnancy groups (each P < .01). The z scores for both the thickness of Rohr fibrinoid layer and % loss of decidua positively correlated with those for the amount of bleeding in deliveries (P < .05 each). Assisted reproductive technology procedures changed the morphology of the placental basal plate, suggesting a possible association with an increase in the amount of bleeding in deliveries.

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Section: Discussionmentioning

confidence: 99%

Morphologic characteristics of the placental basal plate in in vitro fertilization pregnancies: a possible association with the amount of bleeding in delivery

et al. 2015

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“…Fibrin-type fibrinoid contains fibrinogen and fibrin and is characterised by a dense meshwork of fibrin fibres 38 60 61. Fibrin-type fibrinoid is typically void of any cell, especially extravillous trophoblasts.…”

Section: Microscopic Anatomy Of the Delivered Placentamentioning

confidence: 99%

The anatomy of the normal placenta

2008

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The placenta is the fetal organ providing the interchange between mother and fetus. This organ needs to provide its function such as transport and secretion even during its development and thus all developmental changes need to be in accordance with its function. This review describes development of the placenta during the first few weeks of pregnancy until the villous trees with their vasculature are established. The macroscopic anatomy of the delivered placenta as well as the microscopic anatomy and histology of this organ are also described. This includes the different types of villi and the most important cellular components of the villi such as villous trophoblast, Hofbauer cells, mesenchymal cells and endothelium. Fibrinoid and its localisation is also described.

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“…A is stained with HE and B is stained for immunofluorescence. (A and B) X 100. distinguishable f r o m maternal fibrinoid (20), which does not exhibit fluorescence. Fig.…”

Section: Resultsmentioning

confidence: 98%

Localization of a molecule immunochemically similar to eosinophil major basic protein in human placenta.

Maddox¹,

Kephart²,

Coulam³

et al. 1984

The Journal of Experimental Medicine

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The eosinophil granule major basic protein (MBP) 1 is an arginine rich, highly basic, 9,300 dalton protein, which forms the crystalloid core of the granule (1-3) and is present in small amounts in basophils (4). MBP is toxic to parasites (5-7) and is deposited onto the surface of damaged microfiliariae in Onchocerca volvulus infestation (8). MBP is also toxic to cells (5, 9) and causes desquamation of respiratory epithelial cells in vitro (10, 11). Finally, MBP triggers histamine release from human basophils and rat mast cells (12).We have recently reported that MBP circulates in the blood of pregnant women at levels 10 to 20 times those found in normal, nonpregnant women (13). The levels of this immunoreactive MBP increase during the first 3 mo of gestation, plateau during the second and third trimester, and decrease sharply following parturition. Eosinophilia is not present during pregnancy, and other eosinophil-related proteins are not elevated in the sera of pregnant women. Chromatographic analysis of sera from pregnant women indicates that the immunoreactive MBP has an apparent molecular size greater than the molecule purified from the eosinophil granule. These observations suggest that the immunoreactive MBP molecule in the sera of pregnant women is derived from a source other than the eosinophil. Here we report that immunoreactive MBP is localized in placenta, intracellularly in placental X cells and placental-site giant cells and extracellularly in anchoring villi and at the choriodecidual junction. Materials and MethodsTissue. Placental tissue was prepared in the delivery suite for fixation and embedding. First and second trimester medical abortion tissues were kindly provided by Dr. M. Hansen, Minneapolis, MN. Other placental and gestational tissues were available from the Department of Pathology of the Mayo Clinic. Table I lists the types of tissues and the number of blocks examined from each.

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The protein composition of the fibrinoid material at the human uteroplacental interface

Cited by 22 publications

References 27 publications

Morphologic characteristics of the placental basal plate in in vitro fertilization pregnancies: a possible association with the amount of bleeding in delivery

Morphologic characteristics of the placental basal plate in in vitro fertilization pregnancies: a possible association with the amount of bleeding in delivery

The anatomy of the normal placenta

Localization of a molecule immunochemically similar to eosinophil major basic protein in human placenta.

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