1996
DOI: 10.1172/jci118597
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The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells.

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Cited by 172 publications
(107 citation statements)
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“…PAR-2 is widely expressed by vascular endothelial (42)(43)(44) and smooth muscle cells (45,46), and is thought to play a role in the regulation of BP and vascular tone (47). It belongs to the family of G protein-coupled receptors activated by limited proteolysis.…”
Section: Discussionmentioning
confidence: 99%
“…PAR-2 is widely expressed by vascular endothelial (42)(43)(44) and smooth muscle cells (45,46), and is thought to play a role in the regulation of BP and vascular tone (47). It belongs to the family of G protein-coupled receptors activated by limited proteolysis.…”
Section: Discussionmentioning
confidence: 99%
“…HUVEC express abundant amounts of PAR1 and PAR2 on their surface (Nelken et al, 1992;Molino et al, 1997c;D'Andrea et al, 1998;Bahou et al, 1993;Mirza et al, 1996;Nystedt et al, 1996;Ngaiza et al, 1992;Woolkalis et al, 1995a,b) and at least one report suggests that PAR3 is present as well, albeit at lower densities (Schmidt et al, 1998). Responses to thrombin in endothelial cells include an increase in the cytosolic Ca 2+ concentration.…”
Section: Which Receptor(s) Contribute To Thrombin Responses In Any Pamentioning
confidence: 99%
“…These results suggest that PAR2 can be activated by cleaved PAR1 on endothelial cells and allow PAR2 to contribute to the thrombin response ± at least when a selective PAR1 antagonist is present. The fact that even in the absence of the antagonist, selective activation and desensitization of PAR2 reduces subsequent responses to thrombin (Mirza et al, 1996;Molino et al, 1997c;O'Brien et al, 2000) suggests that transactivation of PAR2 by cleaved PAR1 may also occur normally.…”
Section: Transactivation Of Par2 By Cleaved Par1mentioning
confidence: 99%
“…11 Also, more recent findings indicate that endothelial cells express PAR-2 [12][13][14] and that activation of PAR-2 by SLIGRL and trypsin in isolated segments of peripheral arteries also produces endothelium-dependent vascular relaxation. 6 -9,12 The peptide sequence SLIGRL is identical to that of the native tethered ligand of the new amino terminus of PAR-2 in the mouse and the rat, which is exposed on proteolytic cleavage of the PAR-2 exodomain.…”
Section: Functional Importance Of Par-2mentioning
confidence: 99%