The prothrombin 20210A allele and the factor V Leiden are associated with venous thrombosis but not with early coronary artery disease

A Case Control Study on the Contribution of Factor V-Leiden, Prothrombin G20210A, and MTHFR C677T Mutations to the Genetic Susceptibility of Deep Venous Thrombosis

“…While explanation for this remains speculative, it is possible that factors other than FVLeiden and MTHFR 677T/T cooperated with PRT G20210A SNP in increasing the odds of development of VTE. Collectively, this indicated that mutations that enhanced thrombin generation, including FVLeiden [32] or PRT G20210A [32] were independent risk factors of VTE.…”

Renin–angiotensin system and haemostasis gene polymorphisms and outcome after coronary artery bypass graft surgery

“…Furthermore, this polymorphism was associated with the risk of graft occlusion, myocardial infarction and death during a 1-year follow-up after coronary artery bypass graft surgery [13]. The factor V Leiden 1691 G/A gene polymorphism is generally considered to be a risk factor for venous rather than arterial diseases [14]. Nevertheless, this polymorphism has been reported to contribute to the risk of early graft occlusion after coronary artery bypass grafting [15].…”

Comparación de las frecuencias de los alelos factor V Leiden (G1691A) y protrombina-G20210A entre pacientes con trombosis venosa profunda y población general mediterránea española

“…Población General Casos TVP (n=493) (n=131) n (%) n (%) 16 . La frecuencia de esta variante en la provincia de València únicamente es superada por la frecuencia encontrada en Barcelona, donde se estimó un valor de 0,032 7 .…”