2013
DOI: 10.1038/ki.2013.217
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The proto-oncogene c-Fos transcriptionally regulates VEGF production during peritoneal inflammation

Abstract: Vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) are key mediators of adverse peritoneal membrane remodeling in peritoneal dialysis eventually leading to ultrafiltration failure. Both are pleiotropic growth factors with cell type-dependent regulation of expression and biological effects. Here we studied regulation of TGF-β1-induced VEGF expression in human peritoneal mesothelial cells in the absence or presence of proinflammatory stimuli, tumor necrosis factor-α (TNF-α) or i… Show more

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Cited by 60 publications
(77 citation statements)
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“…c-fos stimulation triggers vascular endothelial growth factor-D (VEGF-D) overexpression, which in turn binds to the vascular and lymphatic receptors VEGFR-2 and VEGFR-3, causing tyrosine phosphorylation and, in human umbilical cord vein endothelial cells (HUVEC), activating proliferation, elongation, and branching to form an extensive network of capillary-like cords in three-dimensional matrix 28 . This angiogenic effect initiated by c-FOS-induced VEGF up-regulation has been implicated as an important mechanism for cancer progression and failure of peritoneal dialysis 29, 30 . The LMNA gene encodes lamin A and C that are structural protein elements of intranuclear peripheral thin filamentous meshwork, the nuclear lamina 31, 32 .…”
Section: Discussionmentioning
confidence: 99%
“…c-fos stimulation triggers vascular endothelial growth factor-D (VEGF-D) overexpression, which in turn binds to the vascular and lymphatic receptors VEGFR-2 and VEGFR-3, causing tyrosine phosphorylation and, in human umbilical cord vein endothelial cells (HUVEC), activating proliferation, elongation, and branching to form an extensive network of capillary-like cords in three-dimensional matrix 28 . This angiogenic effect initiated by c-FOS-induced VEGF up-regulation has been implicated as an important mechanism for cancer progression and failure of peritoneal dialysis 29, 30 . The LMNA gene encodes lamin A and C that are structural protein elements of intranuclear peripheral thin filamentous meshwork, the nuclear lamina 31, 32 .…”
Section: Discussionmentioning
confidence: 99%
“…6 ). The compound was incubated with the cells at its EC 50 (1 M), as recommended by the manufacturer, but this concentration has not always proved to be suffi cient to abrogate the effects of AP-1 ( 44,45 ).…”
Section: Discussionmentioning
confidence: 99%
“…Cells were cultured according to the suppliers' instructions. HPMC were isolated and identified as previously described [19].…”
Section: Cell Culturementioning
confidence: 99%