The psychological impact of early pregnancy loss

Farren, J.; Mitchell-Jones, Nicola; Verbakel, Jan Y; Timmerman, Dirk; Jalmbrant, Maria; Bourne, T.

doi:10.1093/humupd/dmy025

Cited by 164 publications

(126 citation statements)

References 36 publications

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“…All of them had received progesterone treatment according to the guidelines of European Progestin Club (EPC). Early threatened abortion is the clinical term for vaginal spotting or bleeding within 12 weeks of gestation 4 . Due to the small sample size and the missing information, we strictly screened the objects according the following exclusion criteria: (1) age is either less than 18 or greater than 40.…”

Section: Study Populationmentioning

confidence: 99%

“…Furthermore, approximately half of women with threatened abortion will suffer from a subsequent miscarriage, especially with higher incidence in the first trimester [2, 3,4]. In China, the number of gravidas is largely increasing due to the Two Child Policy, it means the more women with threatened abortion, the more women who will suffer from pregnancy loss [5].…”

Section: Introductionmentioning

confidence: 99%

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The benefits of higher LMR for early threatened abortion: A retrospective cohort study

Feng

Chen

et al. 2020

PLoS ONE

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To investigate the relation of inflammation-related parameters and pregnancy outcome in women with the early threatened abortion. Method of study 630 women with early threatened abortion were divided into two groups based on the pregnancy outcome. All of them had the blood routine examination before treating. The differences between two groups were analyzed by the Chi-squared test, Student T test, Mann-Whitney U test, Binary Logistic Regression, Marginal Structural Model and Threshold effect analysis. Results We found that there is no significant difference in the pregnancy outcome for NLR (OR:0.92, CI95%:0.72, 1.17) and PLR (OR:1.00, CI%:0.99, 1.01). However, a difference had a statistical significance in the pregnancy outcome when LMR less than 2.19 (OR:0.39, CI95%:0.19,0.82). Conclusions This study suggested that higher LMR was related to the lower risk of miscarriage in the women with early threatened abortion in a way.

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Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

Feng

Chen

et al. 2020

PLoS ONE

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“…Threatened abortion may be one of the most common gynecological conditions and occurs in 25% of pregnancies [2]. Unfortunately, about 10% to 20% of the women who have threatened abortion may experience a miscarriage [2], which may cause depression, anxiety, and even posttraumatic stress symptoms [3].…”

Section: Introductionmentioning

confidence: 99%

Baseline Levels of Serum Progesterone and the First Trimester Pregnancy Outcome in Women with Threatened Abortion: A Retrospective Cohort Study

Deng

Chen

et al. 2020

BioMed Research International

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Objective. The relationship between serum progesterone and the first trimester pregnancy outcome of threatened abortion is still controversial. Therefore, we aimed to further study the association between these two parameters. Methods. The present study is an observational retrospective cohort study. A total of 726 participants who had threatened abortion from a hospital in Guangdong, China, were included in this study from 17th August 2011 to 30th October 2018. The exposure variable and the outcome variable were serum progesterone measured at baseline and early pregnancy outcome, respectively. Covariates involved in this study included patients' basic demographics, obstetric history, and clinical information. Results. A negative association and a saturation effect were detected between serum progesterone and the first trimester pregnancy outcome. When progesterone <90.62 nmol/L, an increase in 1 nmol/L of serum progesterone was associated with 3% decrease of the risk of miscarriage (OR: 0.97, 95% CI: 0.95-0.98). Conclusion. There was a greater risk of abortion when the serum progesterone level was less than 90.62 nmol/L. Our findings can better assist the clinician in understanding patients' conditions and making medical decisions.

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“…Studies have indicated that 32% of women with RM could be classified as depressed, against which having a living child was not a protective buffer 12 . Thus, given its high frequency, RM can significantly contribute to the overall burden of psychopathology within a population, and recognition of this impact is important, so that affected individuals may be cared for appropriately [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

A protocol for a systematic review of clinical practice guidelines for recurrent miscarriage

et al. 2020

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Recurrent miscarriage (RM) was recently re-defined by the European Society of Human Reproduction and Embryology (ESHRE) as the loss of two or more consecutive pregnancies. Before this, and indeed still in some countries, RM was defined as three or more consecutive pregnancy losses. While the incidence of RM depends on the definition employed and population studied, it is generally accepted to affect 1-6% of women of reproductive age. Clinical practice guidelines (CPGs) for RM have been published by some professional organisations. While there are CPGs on miscarriage in Ireland, there are none concerning RM specifically. The aim of this systematic review is to identify, appraise and describe published CPGs for the management, investigation and/or follow-up of RM within high-income countries. Electronic databases (MEDLINE (Ovid®; 1946), Embase® (Elsevier; 1980), CINAHL Complete (EBSCOhost; 1994), Web of Science™ (Thomson Reuters), Scopus (Elsevier; 2004), and Open Grey (INIST-CNRS; 2011)), selected guideline repositories, and the websites of professional societies will be searched to identify CPGs, published within the last 20 years, for potential inclusion. Two reviewers will review abstracts and full texts independently against the eligibility criteria. Characteristics and recommendations of included CPGs will be extracted by one reviewer and double-checked by another. Two reviewers will use the Appraisal of Guidelines for Research and Evaluation version 2 (AGREE II) instrument independently to assess the quality of the included CPGs. Narrative synthesis will be conducted to appraise and compare CPGs and their recommendations or guidance therein. The identification, appraisal and description of published CPGs in other high-income countries will be a valuable first step in informing efforts to promote the optimisation and standardisation of RM care.

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The psychological impact of early pregnancy loss

Cited by 164 publications

References 36 publications

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

Baseline Levels of Serum Progesterone and the First Trimester Pregnancy Outcome in Women with Threatened Abortion: A Retrospective Cohort Study

A protocol for a systematic review of clinical practice guidelines for recurrent miscarriage

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