The COVID-19 pandemic is a public health crisis, and in order to halt it, the spread of the virus needs to be curbed. The World Health Organization and governments have put forward protective guidelines to stop the spread, but adherence to these guidelines is still variable. Through a large survey in twelve countries worldwide (N = 7,755), we show that the information about COVID-19 which is accurate and trustworthy is paramount for the adherence to protective guidelines. Specifically, adherence to safety precautions is predicted by concern, gender, perceived risk, perceived knowledge, and trust in scientists. Adherence to the guidelines was also predicted by distrust in the government and the conspiracy belief that the virus is artificially made; conspiracy thinking predicted self-centered protective behaviors more strongly than safety precautions, however. Conspiracy thinking was predicted by trust in social media, whereas perceived knowledge was associated with trust in reliable COVID-19 websites.