The Purkinje cell; 2008 style

Dun, Wen; Boyden, Penelope A.

doi:10.1016/j.yjmcc.2008.08.001

Cited by 71 publications

(49 citation statements)

References 81 publications

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“…Though identified in human PF cells, a lack of experimental data on I K(ACh) and I CaT prevents their inclusion in the current model, while the presence of I CaT in human PF cells has yet to be observed (Dun & Boyden 2008). The role of I NaL and I CaT has been studied in more detail in canine PF cells (O. V. Aslanidi et al unpublished data), which revealed that I CaT and I K(ACh) played a minor role, whereas the effect of I NaL on the APD was much more prominent.…”

Section: (C ) Limitationsmentioning

confidence: 99%

Mathematical models of the electrical action potential of Purkinje fibre cells

Stewart

Aslanidi

Noble

et al. 2009

Phil. Trans. R. Soc. A.

138

144

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Early development of ionic models for cardiac myocytes, from the pioneering modification of the Hodgkin-Huxley giant squid axon model by Noble to the iconic DiFrancesco-Noble model integrating voltage-gated ionic currents, ion pumps and exchangers, Ca 2C sequestration and Ca 2C -induced Ca 2C release, provided a general description for a mammalian Purkinje fibre (PF) and the framework for modern cardiac models. In the past two decades, development has focused on tissue-specific models with an emphasis on the sino-atrial (SA) node, atria and ventricles, while the PFs have largely been neglected. However, achieving the ultimate goal of creating a virtual human heart will require detailed models of all distinctive regions of the cardiac conduction system, including the PFs, which play an important role in conducting cardiac excitation and ensuring the synchronized timing and sequencing of ventricular contraction. In this paper, we present details of our newly developed model for the human PF cell including validation against experimental data. Ionic mechanisms underlying the heterogeneity between the PF and ventricular action potentials in humans and other species are analysed. The newly developed PF cell model adds a new member to the family of human cardiac cell models developed previously for the SA node, atrial and ventricular cells, which can be incorporated into an anatomical model of the human heart with details of its electrophysiological heterogeneity and anatomical complexity.

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Section: (C ) Limitationsmentioning

confidence: 99%

Mathematical models of the electrical action potential of Purkinje fibre cells

Stewart

Aslanidi

Noble

et al. 2009

Phil. Trans. R. Soc. A.

138

144

View full text Add to dashboard Cite

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“…Although fascicle system is composed of specific fibers with discrete conduction ability, activations could propagate with rapid speed. 14,15 Therefore, the initial stage of ILVT is always seen with the depolarization of conduction system. During SR, activation time between the distal ends of LAF and LPF is only a difference of 8.2 ms, and both fascicles contribute relatively equal to the depolarization of ventricle.…”

Section: Depolarization Of Fascicle System and Ventricle During Ilvtmentioning

confidence: 99%

Isolated Conduction Within the Left His-Purkenje System During Sinus Rhythm and Idiopathic Left Ventricle Tachycardia

Long

Dong

Sang

et al. 2013

Circ: Arrhythmia and Electrophysiology

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Electrophysiology study was performed after written informed consent and withdrawing antiarrhythmic drug for ≥5 half-lives. Diagnostic catheters, including 2 quadripolar catheters and 1 quadripolar or octapolar catheter (Biosense-Webster Inc, Diamond Bar, CA), were deployed to His-bundle position, right ventricular apex, and coronary sinus, respectively. A 4-mm, 4-pole cool saline-irrigated catheter (Navi-Star Thermo-Cool, Biosense-Webster Inc, Diamond Bar, CA) compatible with CARTO system (CARTO, Biosense-Webster Inc, Diamond Bar, CA) was introduced into left ventricle (LV) via retrograde approach for activation mapping, geometry reconstruction, © 2013 American Heart Association, Inc. Circ Arrhythm Electrophysiol

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“…These mechanical findings are in accordance with previous electric LQTS models reporting the longest APD in Purkinje cells and M cells located in the subendocardium and midmyocardium. 4,5,26 The APD of subendocardial Purkinje fibers in vitro has been reported to be even longer than in the M cells, but the delayed repolarization of the Purkinje system has failed to register on the ECG. 5 Purkinje cells are found in the His bundle and bundle branches and cover much of the endocardium.…”

Section: Mechanical Abnormalities In Lqts Patientsmentioning

confidence: 99%

“…2,3 The longest APD in LQTS models has been reported in endocardial Purkinje cells and in subendocardial to midmyocardial cells (M cells). 4,5 Transmural differences in APD have been considered to be of major importance in arrhythmogenesis in LQTS patients. 6 However, it has been challenging to assess APD and dispersion in patients.…”

mentioning

confidence: 99%

Transmural Differences in Myocardial Contraction in Long-QT Syndrome

et al. 2010

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Background-Long-QT syndrome (LQTS) is characterized by prolonged myocardial action potential duration. The longest action potential duration is reported in the endomyocardium and midmyocardium. Prolonged action potential duration in LQTS may cause prolonged cardiac contraction, which can be assessed by strain echocardiography. We hypothesized that myocardial contraction is most prolonged in subendocardial myofibers in LQTS patients and that inhomogeneous transmural contraction is related to the risk of spontaneous arrhythmia. Methods and Results-We included 101 genotyped LQTS mutation carriers and 35 healthy individuals. A history of cardiac arrhythmias was present in 48 mutations carriers, and 53 were asymptomatic. Myocardial contraction duration was assessed by strain echocardiography as time from the ECG Q wave to peak strain in 16 LV segments. Strain was assessed along the longitudinal axis, predominantly representing subendocardial fibers, and along the circumferential axis, representing midmyocardial fibers. Mean contraction duration was longer in LQTS mutation carriers compared with healthy individuals (445Ϯ45 versus 390Ϯ40 milliseconds; PϽ0.001) and longer in symptomatic compared with asymptomatic LQTS mutation carriers (460Ϯ40 versus 425Ϯ45 milliseconds; PϽ0.001). Contraction duration by longitudinal strain was longer than by circumferential strain in symptomatic LQTS patients (460Ϯ45 versus 445Ϯ45 milliseconds; Pϭ0.008) but not in asymptomatic patients and healthy individuals, indicating transmural mechanical dispersion. This time difference was present in a majority of LV segments and was most evident in patients with LQT2 and the Jervell and Lange-Nielsen syndrome. Conclusion-Contraction duration in symptomatic LQTS mutation carriers was longer in the subendocardium than in the midmyocardium, indicating transmural mechanical dispersion, which was not present in asymptomatic and healthy individuals. (Circulation. 2010;122:1355-1363.)

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The Purkinje cell; 2008 style

Cited by 71 publications

References 81 publications

Mathematical models of the electrical action potential of Purkinje fibre cells

Mathematical models of the electrical action potential of Purkinje fibre cells

Isolated Conduction Within the Left His-Purkenje System During Sinus Rhythm and Idiopathic Left Ventricle Tachycardia

Transmural Differences in Myocardial Contraction in Long-QT Syndrome

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