The Putative Association of TOB1-AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients

Dehghanzad, Reyhaneh; Kakhki, Majid Pahlevan; Alikhah, Asieh; Sahraian, Mohammad Ali; Behmanesh, Mehrdad

doi:10.1007/s12017-019-08567-1

Cited by 3 publications

(3 citation statements)

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“…Dehghanzad et al. demonstrated the abnormal expression levels of TOB1-AS1 and its targets genes TOB1 , TSG , and SKP2 in the blood of MS. Downregulation of TOB1-AS1 might cause dysregulation of the target genes and participate in the progression of MS ( 30 ). TOB1-AS1 enhances the expression of the TOB1 gene via suppressing the production of IL-2 ( 90 ).…”

Section: Resultsmentioning

confidence: 99%

“…TOB1 antisense RNA 1 (TOB1-AS1) is transcribed from the opposite orientation of the TOB1 gene on chromosome 17q21.33, a region with an important role in maintaining immune tolerance (19). Dehghanzad et al demonstrated the abnormal expression levels of TOB1-AS1 and its targets genes TOB1, TSG, and SKP2 in the blood of MS. Downregulation of TOB1-AS1 might cause dysregulation of the target genes and participate in the progression of MS (30). TOB1-AS1 enhances the expression of the TOB1 gene via suppressing the production of IL-2 (90).…”

Section: Tob1-as1mentioning

confidence: 99%

“…An in vitro study revealed the positive feedback between TOB1 and S-phase kinase-associated protein 2 (SKP2). Elevation of TOB1-AS1 levels causes increased TOB1 and thus increased the TSG levels (30). LncRNAs With Roles in Innate Immune Response Lnc-DC and THRIL…”

Section: Tob1-as1mentioning

confidence: 99%

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Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

et al. 2021

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Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is one of the most common neurodegenerative diseases worldwide. MS results in serious neurological dysfunctions and disability. Disturbances in coding and non-coding genes are key components leading to neurodegeneration along with environmental factors. Long non-coding RNAs (lncRNAs) are long molecules in cells that take part in the regulation of gene expression. Several studies have confirmed the role of lncRNAs in neurodegenerative diseases such as MS. In the current study, we performed a systematic analysis of the role of lncRNAs in this disorder. In total, 53 studies were recognized as eligible for this systematic review. Of the listed lncRNAs, 52 lncRNAs were upregulated, 37 lncRNAs were downregulated, and 11 lncRNAs had no significant expression difference in MS patients compared with controls. We also summarized some of the mechanisms of lncRNA functions in MS. The emerging role of lncRNAs in neurodegenerative diseases suggests that their dysregulation could trigger neuronal death via still unexplored RNA-based regulatory mechanisms. Evaluation of their diagnostic significance and therapeutic potential could help in the design of novel treatments for MS.

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Section: Resultsmentioning

confidence: 99%

Section: Tob1-as1mentioning

confidence: 99%

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Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

et al. 2021

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Significant Association of rs77493513 Polymorphism in 3'-UTR of the NRG1 Gene with the Risk of Multiple Sclerosis Disease

Ghorbani

Moghanibashi

2022

Metab Brain Dis

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Prediction of Single-Nucleotide Polymorphisms within microRNAs Binding Sites of Neuronal Genes Related to Multiple Sclerosis

Dehghanzad

Moghadam

Shirvani-Farsani

2021

Advanced Biomedical Research

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Background: Different genetic variants, including the single-nucleotide polymorphisms (SNPs) present in microRNA recognition elements (MREs) within 3'UTR of genes, can affect miRNA-mediated gene regulation and susceptibility to a variety of human diseases such as multiple sclerosis (MS), a disease of the central nervous system. Since the expression of many genes associated with MS is controlled by microRNAs (miRNAs), the aim of this study was to analyze SNPs within miRNA binding sites of some neuronal genes associated with MS. Materials and Methods: Fifty-seven neuronal genes related to MS were achieved using dbGaP, DAVID, DisGeNET, and Oviddatabases. 3'UTR of candidate genes were assessed for SNPs, and miRNAs' target prediction databases were used for predicting miRNA binding sites. Results: Three hundred and eight SNPs (minor allele frequency >0.05) were identified in miRNA binding sites of 3'UTR of 44 genes. Among them, 42 SNPs in 22 genes had miRNA binding sites and miRNA prediction tools suggested 71 putative miRNAs binding sites on these genes. Moreover, in silico analysis predicted 22 MRE-modulating SNPs and 22 MRE-creating SNPs in the 3'UTR of these candidate genes. Conclusions: These candidate MRE-SNPs can alter miRNAs binding sites and mRNA gene regulation. Therefore, these genetic variants and miRNAs might be involved in MS susceptibility and pathogenesis and hence would be valuable for further functional verification investigation.

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The Putative Association of TOB1-AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients

Cited by 3 publications

References 45 publications

Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review

Significant Association of rs77493513 Polymorphism in 3'-UTR of the NRG1 Gene with the Risk of Multiple Sclerosis Disease

Prediction of Single-Nucleotide Polymorphisms within microRNAs Binding Sites of Neuronal Genes Related to Multiple Sclerosis

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