The puzzle of spontaneous versus traumatic intracranial hemorrhages

Abstract

Intracerebral hemorrhage is hemorrhage occurring in the brain that can occur because of immediate trauma or structural disease process. The age-standardized mortality rate is decreasing worldwide especially in the past 20 years, but the number of cases and incidence along with number of disability-adjusted life-years and deaths keeps rising. Despite having half the incidence as ischemic stroke, intracerebral hemorrhage (traumatic or spontaneous) causes more morbidity and mortality than ischemic stroke and yet an established strategy for treatment on the lines of reperfusion therapy is a far-fetched dream. A selective review of all relevant articles covering recent treatment options and guidelines along with major emphasis of the surgical aspect and pathophysiology has been done. Complete literature review and differences between management of traumatic and spontaneous hemorrhage were sought and discussed. A pathophysiological basis of management should be followed for both these different yet similar pathologies. Understanding the etiology reveals a somewhat clearer picture regarding treatment of this highly unfortunate and devastating disease. Current interest is focused on the surgical management of the disease with the pathophysiology often been forgotten.

Metabolic Insight Into the Neuroprotective Effect of Tao-He-Cheng-Qi (THCQ) Decoction on ICH Rats Using Untargeted Metabolomics

“…Intracerebral hemorrhage (ICH) is primarily classified clinically as spontaneous (e.g., haemorrhagic stroke) or traumatic, and it accounts for 9–27% of all strokes worldwide ( Qureshi et al, 2009 ; Shah et al, 2019 ; Quiñones-Ossa et al, 2020 ; Xu et al, 2020 ). When it is caused by non-traumatic or spontaneous ICH, the physician must consider different etiologies ( Steiner et al, 2014 ).…”