The pyrrole moiety as a template for COX-1/COX-2 inhibitors

Synthesis and Structure Activity Relationship of Some Indole Derivatives as Potential Anti-inflammatory Agents

“…[23][24][25][26][27][28] Pyrrolylacetic acid derivatives such as tolmetin (Rumatol ® ) and zomepirac (Zomax ® ) were proved to be NSAIDs 6 with strong anti-inflammatory activity. 29,30 Other pyrrole and fused pyrrole compounds have been recently reported as potent COX-1 and COX-2 inhibitors: 31,32 4-benzodioxine or pyrrole nucleus are described. All the newly synthesized compounds were examined for their in vitro and in vivo anti-inflammatory activity.…”

One-pot synthesis of new series 3,4,5-trisubstituted–dihydroisoxazoline derivatives via 1,3-dipolar cycloaddition of nitrile oxides with chalcones

“…Cycloaddition of nitrile oxide to olefinic * For correspondence compounds are of synthetic interest, since the resulting isoxazolines are versatile intermediates for the synthesis of bifunctional compounds. 14 Nitrile oxides can be generated by dehydrogenation of aryl aldoximes with mercuric acetate, 15 manganese dioxide, 16 tertbutyl hypochlorite, 17 chloramine-T. 18 In 1989 Hassner and Rai have reported the synthesis of isoxazolines via the formation of nitrile oxides from crossponding oxime and the subsequent reaction with olefins and suggested a mechanism for the reaction. 19 Recently, Ganoker et al used chloramine-T for the generation and cycloaddition of α-nitrosoolefin and α-azoalkenes from ketoximes and ketone hydrazones, 20 respectively.…”

Synthesis and antimicrobial activity of some new pyrrole derivatives

“…Pyrrole derivatives are of considerable synthetic importance due to their extensive used in drug discovery [1] which is linked to their pharmacological activity such as anti-inflammatory [2], cytotoxicity [3][4][5][6], treatment of hyperlipidemias [7] and antitumour agents [8]. The pyrrole containing other heterocyclic compounds has been reported previously for biological studies [9].…”