The Quality of Life and Psychosocial Implications of Cancer-Related Lower-Extremity Lymphedema: A Systematic Review of the Literature

Bowman, Carolyn; Piedalue, Katherine-Ann; Baydoun, Mohamad; Carlson, Linda E.

doi:10.3390/jcm9103200

Cited by 40 publications

(42 citation statements)

References 56 publications

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“…The sclerotic lymphatic vessels lose functions such as lymph transport [ 14 , 15 , 17 , 18 ]. In addition, long-term compression management burdens the patient and often diminishes the patient’s quality of life [ 19 ]. It has been suggested that further surgical treatment lowers the burden on patients and improves their quality of life by allowing compression to be reduced or discontinued [ 15 , 16 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Who Will Continuously Depend on Compression to Control Persistent or Progressive Breast Cancer-Related Lymphedema Despite 2 Years of Conservative Care?

Jung

Kim

Seo

et al. 2020

JCM

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Background: When a patient with breast cancer-related lymphedema (BCRL) depends on continuous compression management, that is, when interstitial fluid accumulation is continuously ongoing, surgical treatment should be considered. Physiologic surgery is considered more effective for early-stage lymphedema. The purpose of this study was to identify predictors of patients with BCRL who will be compression-dependent despite 2 years of conservative care. Methods: This study included patients with BCRL who followed up for 2 years. Patients were classified into two groups (compression-dependent vs. compression-free). We identified the proportion of compression-dependent patients and predictors of compression dependence. Results: Among 208 patients, 125 (60.1%) were classified into the compression-dependent group. Compression dependence was higher in patients with direct radiotherapy to the lymph nodes (LNs), those with five or more LNs resections, and those with BCRL occurring at least 1 year after surgery. Conclusions: BCRL patients with direct radiotherapy to the LNs, extensive LN dissection, and delayed onset may be compression-dependent despite 2 years of conservative care. Initially moderate to severe BCRL and a history of cellulitis also seem to be strongly associated with compression dependence. Our results allow for the early prediction of compression-dependent patients who should be considered for physiologic surgery.

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Section: Introductionmentioning

confidence: 99%

Who Will Continuously Depend on Compression to Control Persistent or Progressive Breast Cancer-Related Lymphedema Despite 2 Years of Conservative Care?

Jung

Kim

Seo

et al. 2020

JCM

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“…Research data showed that these changes are indirectly associated with the destruction of endothelial cells and vascular membranes, leading to perivascular edema, changes in the structure of muscle fibers, and disruption of one of the mechanisms of venous outflow from the lower extremities [4,16,17]. Despite the experimental study carried out, it can be assumed that remodeling of muscle fibers with subsequent impairment of their function leads to a slowdown in venous outflow, vascular damage, and an increase in thrombus formation in the veins of the lower extremities in patients with cancer.…”

Section: Discussionmentioning

confidence: 99%

Histological Changes in Muscles During the Lower Extremities Thrombosis in Individuals with Gastrointestinal Tract Cancer

Bodnar¹,

Bodnar²,

Bodnar³

et al. 2021

Int j pharm res allied sci

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Thrombosis is a common complication in cancer patients. In all cancer patients, changes occur that lead to arterial and venous thrombosis. It is not known for certain what exactly provokes the appearance of blood clots and causes disseminated intravascular coagulation (DIC). A morpho-histological study of the muscles of the lower extremities was carried out in two groups of people who suffered from cancer and had deep vein thrombosis of the lower extremities with subsequent migration of blood clots. In two groups of people who died due to the migration of blood clots from the veins of the lower extremities in the pulmonary artery, clear dystrophic changes in muscle fibers were found with narrowing of all arterioles and a strong expansion of the venous vessels. In all the venous vessels of the preparation, damage to the endothelium was found, which may indicate the presence of thrombosis of the venous vessels carrying blood from the muscles. People with cancer of the pancreas and/or colon have significant hemodynamic, hypertrophic, dystrophic, and atrophic changes in muscle fibers. There are signs of a systemic effect of the tumor on the vessels and hemodynamics in the lower extremities.

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“…Основний координатор всіх досліджень в області ЯЖ -MAPI Research Institute -щорічно проводить конгреси International Society of Quality of Life Research, гаслом яких є «ціль будь-якого лікування -наближення ЯЖ хворих до рівня ЯЖ практично здорових людей. Основний інструмент для визначення ЯЖ -це стандартизовані опитувальники, що складені за допомогою психометричних методів [8].…”

Section: оцінка якості життя онкогінекологічних хворих після проведеної гістероваріектомії асоційованої з тромботичними ускладненнямиunclassified

Assessment of the Quality of Life of Oncological Patients Following Hysterovariectomy Associated with Thrombotic Complications

Bodnar¹

2021

Ukr. ž. med. bìol. sportu

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Oncological treatment for post-operative patients is aimed to improve their symptomatic course and life prognosis. However, the subjection of a woman following radical intervention in her reproductive system has a devastating effect on the quality of life in this cohort of patients. Quality of life is one of the modern criteria for assessing the effectiveness of health care. The main tool for measuring quality of life is the standardized questionnaires produced by psychometric methods. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire was used to assess the quality of life of women with cancer with post-operative thrombotic complications. The purpose of the study was to assess the indicators dynamics of the quality of life in oncological patients before and after a hysterovariectomy associated with thrombotic complications. Materials and methods. In accordance with the purpose of the study, a comprehensive examination of 34 women with oncological diseases of the uterus and appendages with postoperative deep vein thrombosis, who were in hospital, was done. The average age of patients was 51.4 士 3.5. All patients underwent hysterovariectomy. The control group consisted of 30 healthy women. The set of diagnostic and therapeutic measures included a thorough clinical examination with anamnesis, features of menstrual and reproductive functions, transvaginal ultrasound scanning, hysteroscopy and histological examination of macrodrugs removed during surgery. The groups were compared by age, volume of surgery and comorbidities. Results and discussion. Analysis of the initial results of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire in oncological patients showed a low statistically significant score in all its scales compared to practically healthy women (p <0.05). In the group of patients with post-operative thrombotic complications, after a hysterovariectomy, there was an evident decrease by 46.5% in physical activity compared to the initial data (p <0.05). In the context of therapy, there has been a decrease in social contacts and in the level of communication due to physical and emotional limitations (p <0.05). The decline in quality of life was associated with an increase in sexual dysfunction in 100% of cases. Conclusion. The assessment of indicators of quality of life in patients with malignant neoplasia of the gynaecological sphere must be monitored before and after rapid treatment to determine the necessary social-medical algorithm of actions to adapt such patients during the rehabilitation period

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The Quality of Life and Psychosocial Implications of Cancer-Related Lower-Extremity Lymphedema: A Systematic Review of the Literature

Cited by 40 publications

References 56 publications

Who Will Continuously Depend on Compression to Control Persistent or Progressive Breast Cancer-Related Lymphedema Despite 2 Years of Conservative Care?

Who Will Continuously Depend on Compression to Control Persistent or Progressive Breast Cancer-Related Lymphedema Despite 2 Years of Conservative Care?

Histological Changes in Muscles During the Lower Extremities Thrombosis in Individuals with Gastrointestinal Tract Cancer

Assessment of the Quality of Life of Oncological Patients Following Hysterovariectomy Associated with Thrombotic Complications

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