The quantitative investigation of FEDBD plasma on skin parameters: skin elasticity, thickness, density, tissue oxygenation, perfusion, and edema

Abstract

Beauty and youth are the most critical and challenging issues in medicine and beauty science, and humans always seek to find a new method for the elixir of youth. Innovative technologies based on physical principles have also been presented in recent years. In the meantime, cold plasma technology, which previously showed exciting results in the skin, is currently being investigated due to its remarkable ability to treat diseases and skin care. This study used the FEDBD plasma device for skin rejuvenation in animal samples. There were two groups of six male Wistar rats. One group was treated with plasma with a power of 3.3 W, and the second group was considered the control group for a better comparison. Plasma processing was done on the back of the neck of mice with an area of 18 square centimeters. So far, complete quantitative measurement has not been done, and few studies have been done. Before starting the treatment, immediately after the treatment, the fourth week, and the tenth week of follow-up, biometric tests were performed, including moisture level, evaporation from the skin surface, erythema and melanin, skin elasticity and firmness with an MPA9 device and cutometer. The thickness and density of the epidermis and dermis, an essential indicator in rejuvenation, were evaluated with a skin ultrasound device. Also, the level of oxygen, perfusion, and interstitial water (edema) was checked using a Tivita tissue hyperspectral camera at a depth of 6 mm of the skin. Active species produced by plasma, plasma temperature, and device power were investigated and recorded using physical tests.