a b s t r a c tMany studies investigated solar-terrestrial responses (thermal state, O 3 , OH, H 2 O) with emphasis on the tropical upper atmosphere. In this paper the focus is switched to water vapor in the mesosphere at a mid-latitudinal location. Eight years of water vapor profile measurements above Bern (°°46.88 N/7.46 E) are investigated to study oscillations with the focus on periods between 10 and 50 days. Different spectral analyses revealed prominent features in the 27-day oscillation band, which are enhanced in the upper mesosphere (above 0.1 hPa, ∼64 km) during the rising sunspot activity of solar cycle 24. Local as well as zonal mean Aura MLS observations support these results by showing a similar behavior. The relationship between mesospheric water and the solar Lyman-α flux is studied by comparing the similarity of their temporal oscillations. The H 2 O oscillation is negatively correlated to solar Lyman-α oscillation with a correlation coefficient of up to −0.3 to −0.4, and the phase lag is 6-10 days at 0.04 hPa. The confidence level of the correlation is ≥99%. This finding supports the assumption that the 27-day oscillation in Lyman-α causes a periodical photodissociation loss in mesospheric water. Wavelet power spectra, cross-wavelet transform and wavelet coherence analysis (WTC) complete our study. More periods of high common wavelet power of H 2 O and solar Lyman-α are present when amplitudes of the Lyman-α flux increase. Since this is not a measure of physical correlation a more detailed view on WTC is necessary, where significant (two sigma level) correlations occur intermittently in the 27 and 13-day band with variable phase lock behavior. Large Lyman-α oscillations appeared after the solar superstorm in July 2012 and the H 2 O oscillations show a well pronounced anti-correlation. The competition between advective transport and photodissociation loss of mesospheric water vapor may explain the sometimes variable phase relationship of mesospheric H 2 O and solar Lyman-α oscillations. Generally, the WTC analysis indicates that solar variability causes observable photochemical and dynamical processes in the mid-latitude mesosphere.