The Quercetine Containing Drugs in Pharmacological Correction of Experimental Diabetes with Myocardial Injury

Stechyshyn, Iryna; Pavliuk, Bohdana

doi:10.2478/rjdnmd-2019-0042

Cited by 7 publications

(7 citation statements)

References 3 publications

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“…With the help of cytoplasmic processes, they contact the epitheliocytes of the basal and parabasal layers within their diferon, causing their vertical anisomorphism and regulating the processes of proliferation and specialization.Due to the synthesis of keylonlike substances, Langerhans cells inhibit the proliferative activity of basal epitheliocytes. Nedavna istraživanja 15,16 pokazala su to da su metabolički procesi u epitelnim tkivima oralne sluzokože hormonski zavisni. Receptori za brojne hormone, uključujući estradiol, koji se uglavnom nalazi u ćelijskim jezgrima parabazalnog i bazalnog sloja, otkriveni su u epitelocitima gingivalne mukoze.…”

Section: Results Anddiscussionunclassified

Modern view on mechanisms of epithelium differentiation of the oral mucosa in normal and pathological processes

Hasiuk¹,

Bozhyk²,

Radchuk³

2021

Acta stomatologica Naissi

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Background:In everyday clinical practice, patients who seek dental care in case of oral mucosa diseases are one of the most difficult categories of patients due to difficulties in diagnosis and treatment. Materials and methods: The review and analysis of scientific and medical literature based on the Scopus, Web of Science, MedLine, PubMed, NCBI databases, the study of which does not exceed 5 years, including literature reviews and the results of clinical trials. Results: Changes in the oral mucosa can be clearly specific. Clinicians can make the correct diagnosis and determine the tactics of treatment by appearance. However, in most cases the diagnosis of diseases with this anatomical location is complicated, because the clinical picture is nonspecific and often burdened with additional local and general adverse factors. A detailed clinical examination and additional research methods are required to establish the correct diagnosis. Diagnosis of oral mucosa diseases is based on a careful assessment of clinical and laboratory data. Conclusions: Taking into account the prevalence of diseases of the oral mucosa, of particular interest is the question of the course of the process of differentiation of the epithelium of various anatomical zones in the norm and the mechanisms of restructuring of the cellular composition in pathological processes, with the cops of objectifying the diagnosis, predicting the course of the disease and pathogenetically substantiated treatment.

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Section: Results Anddiscussionunclassified

Modern view on mechanisms of epithelium differentiation of the oral mucosa in normal and pathological processes

Hasiuk¹,

Bozhyk²,

Radchuk³

2021

Acta stomatologica Naissi

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“…Wang et al [20], after establishing the structure of quercetin by spectroscopic data, studied its cardioprotective properties. The cardioprotective effects of quercetin against oxidative stress of H9c2 cells induced by H 2 O 2 showed quercetin derivatives exhibited protective effects against H9c2 cells injury induced by H 2 O 2 The cardioprotective effects of quercetin-containing drugs, corvitin and lipoflavon, were reported first time by Stechyshyn and Pavliuk [21]. Quercetin can relieve endoplasmic reticulum dysfunction in Pak2-CKO hearts.…”

Section: Quercetin As a Cardioprotective Agentmentioning

confidence: 98%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

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Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

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“…To understand the mechanism of action of lyophilized DBH powder on glucose levels, it is necessary to further study the effect of this APhI on hydrocarbon metabolism. From the analyzed scientific literature, it can be assumed that the glycemia of the lyophilized powder of drone homogenate can be influenced by the flavonoids present in it by inhibiting the absorption of glucose in the intestine or by influencing its absorption by peripheral tissues (Pavliuk et al 2020;Stechyshyn et al 2020;Budniak et al 2021). Flavonoids are known to accelerate the use of glucose in the liver and skeletal muscle cells by activating key glycolysis enzymes hexokinase and pyruvate kinase, reduce glycogen phosphorylase activity and stimulate glycogen production in the liver and skeletal muscle cells (Pavliuk et al 2020;Shanaida et al 2020;Stechyshyn et al 2020).…”

Section: Secretionmentioning

confidence: 99%

“…Kritsak et al 2021). MetS is an integral symptom complex of combined pathological processes, including diabetes mellitus and cardiovascular diseases Stechyshyn et al 2020;Pavlyshyn et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…By binding excess peroxide compounds in metabolic syndrome, drone homogenate directly affects another important factor, oxidative stress (Pavliuk et al 2020;Marushchak et al 2021). Nowadays, as the basis of the universal theory of the development of all complications in MetS, oxidative stress is considered, including as a result of endothelial dysfunction and depletion of antioxidant protection (Stechyshyn et al 2020). Moreover, oxidative stress induced by hyperglycemia triggers the mechanisms of β-cell damage.…”

Section: Introductionmentioning

confidence: 99%

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Preclinical safety evaluation of drone brood homogenate and justification of pharmacological action

Pavliuk¹,

Stechyshyn²,

Chubka³

et al. 2021

PHAR

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The problem of studying the metabolic syndrome, as well as its integration into other pathological processes, despite large-scale research, remains relevant. The complexity of the interaction of different links in pathogenesis requires scientists to find new tools and methods for both diagnosis and treatment. Drone brood homogenate, which is a multifactorial pharmacological agent in terms of chemical composition, seems to be promising to study for today. And the lack of contraindications and a wide age range makes it an excellent object of research. The current study evaluated the pharmacological aspects of safety: acute toxicity, effects on the functional and motor activity of the gastrointestinal tract, as well as local irritation of the gastric mucosa, the secretory function of the stomach. All experiments were performed according to the classical methods. The specific pharmacological activity of the drone brood homogenate was determined in comparison with metformin in the experimental fructose metabolic syndrome. Animals obtained from the Vivarium of I.Horbachevsky Ternopil National Medical University were used to implement the set goals. Working with animals was met all bioethical requirements. The study found that the lyophilized drone brood homogenate does not have a local irritant effect and does not cause ulcers on the surface of the gastric mucosa, does not affect the secretory function of the stomach and motor-evacuatory activity of the gastrointestinal tract and is a low-toxic substance, indicating the possibility of its long-term safe use. As expected, glucose, insulin, and HOMA index were significantly increased in animals that were simulated metabolic syndrome. The use of drone brood homogenate by animals contributed to a relatively positive effect on selected indicators of the metabolic syndrome. Accordingly, drone brood homogenate is a promising active pharmaceutical ingredient for the normalization of biochemical disorders in metabolic syndrome.

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The Quercetine Containing Drugs in Pharmacological Correction of Experimental Diabetes with Myocardial Injury

Cited by 7 publications

References 3 publications

Modern view on mechanisms of epithelium differentiation of the oral mucosa in normal and pathological processes

Modern view on mechanisms of epithelium differentiation of the oral mucosa in normal and pathological processes

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Preclinical safety evaluation of drone brood homogenate and justification of pharmacological action

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