The Question of Sensitiveness to Non Bacterial Toxins and Proteins.*

Whitfield, F.R.C.P. Arthur

doi:10.1111/j.1365-2133.1922.tb11342.x

Cited by 18 publications

(4 citation statements)

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“…Radioiodinated human serum albumin has been extensively used to investigate albumin metabolism in the normal and in diseased states (1)(2)(3). Albumin preparations used in these studies have been indistinguishable from normal human serum albumin in many respects but not in all ( 1,2,4,5).…”

Section: Resultsmentioning

confidence: 99%

Failure to Sensitize to Autologous Skin.

Rosenthal¹,

Baer²,

Hagel³

1958

Experimental Biology and Medicine

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Section: Resultsmentioning

confidence: 99%

Failure to Sensitize to Autologous Skin.

Rosenthal¹,

Baer²,

Hagel³

1958

Experimental Biology and Medicine

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“…The concept of autoimmune dermatitis, initially referred to as “auto-sensitization” or “autoeczematization”, was first presented a century ago [ 112 ]. In the following decades, it remained a rather “niche” topic limited to clinical observations that a considerable group of children and adults with eczema react on patch or scratch tests with extracts from human dander, i.e., antigens from their own or donor keratinocytes, and develop skin reactions consistent with their disease (summarized in [ 113 , 114 ]).…”

Section: An Overview Of Diseases From the Spectrummentioning

confidence: 99%

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Śpiewak

2023

IJMS

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Researchers active in the field of inflammatory skin diseases from the spectrum of dermatitis and eczema are well aware of a considerable overlap in the clinical pictures and proposed sets of diagnostic criteria for these diseases, which can hardly be overcome through the clinical or epidemiological research. In effect, patients are included in studies based on vague and overlapping criteria, while heterogeneous study populations may, in turn, lead to non-representative outcomes and continued confusion. In this narrative review, a systematics of diseases from the spectrum of dermatitis and eczema is proposed based on the origins of causative factors and the pathomechanisms involved. Difficulties in differentiating between these diseases are discussed, and the extent to which advances in the “omics” sciences might help to overcome them is considered. Of all the “omics” research in this field, more than 90% of the published papers were devoted to atopic dermatitis, with a striking underrepresentation of other diseases from the spectrum of dermatitis and eczema, conditions which collectively exceed the rates of atopic dermatitis by far. A greater “omics” research effort is urgently needed to tackle other dermatitides, like allergic, irritant and protein contact dermatitis, as well as radiation, seborrheic, stasis or autoimmune dermatitis. Atopic dermatitis findings should be validated not only against healthy donors but also other dermatitides. A clinic-oriented approach is proposed for future “omics” studies in the field of dermatitis and eczema.

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“…Any primary focus of eczema, where, through injudicious medication or in some other way, the skin is irritated, can act anti‐genically to excite secondary eczematides in other parts; this is Whitfield's autosensitization eruption, or autolytic eczema (Whitfield, 1922). An eczematous drug eruption following internal administration probably comes about through allergy.…”

Section: Modern Periodmentioning

confidence: 99%

Eczema

Feiwel

1953

Int J Clinical Practice

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lIIEDICINE ILLUSTRATE D Eczem a 21 9ECZEMA IS one of the commonest skin diseases and presents many problems both for the practitioner and the specialist. HISTORY R. .A century and a half ago the Englishmen, obert Willan and Thomas Bateman (I8Ig) made a great advance in the study and Classification of skin disease when they gave precision to their concept of eczema.Morphology, Aetiology and Pathogenesis. The erUption is essentially a vesicular one.Eczema arises as the result of irritants e~ternally or sometimes internally reaching t e skin. Bateman listed the medicament ~ercu.ry, sugar encountered by grocers, lime . Y. bricklayers, and sunlight as examples of Irritants.

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The Question of Sensitiveness to Non Bacterial Toxins and Proteins.*

Cited by 18 publications

References 0 publications

Failure to Sensitize to Autologous Skin.

Failure to Sensitize to Autologous Skin.

Diseases from the Spectrum of Dermatitis and Eczema: Can “Omics” Sciences Help with Better Systematics and More Accurate Differential Diagnosis?

Eczema

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