The questionable physiologic and epidemiologic basis for a male climacteric syndrome: preliminary results from the Massachusetts Male Aging Study

McKinlay, John B.; Longcope, Christopher; Gray, Anna

doi:10.1016/0378-5122(89)90003-0

Cited by 75 publications

(35 citation statements)

References 65 publications

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“…The field protocol of the MMAS has been previously described [4][5][6][7]. Briefly, a trained interviewer visited each subject in his home and completed the health questionnaire, psychological instruments, physiological measurements, and blood sampling.…”

Section: Sampling and Data Collectionmentioning

confidence: 99%

A new surrogate variable for erectile dysfunction status in the Massachusetts male aging study

Kleinman

Feldman

Johannes

et al. 2000

Journal of Clinical Epidemiology

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Erectile dysfunction (ED) is the subject of a vast clinical literature, but little information has been gathered from random samples of the general public. The Massachusetts Male Aging Study (MMAS) addressed this important aspect of men's health. The MMAS was conducted in two waves, with baseline data collection in 1987-1989 and follow-up in 1995-1997. Subsequent to the baseline MMAS survey, a consensus developed that subjective measures are optimal for defining ED. Unfortunately, the baseline questionnaire did not ask subjects directly about their erectile functioning. Thus, we previously assigned the MMAS subjects a degree of impotence at baseline using a series of related questions, employing a discriminant formula constructed from a separate sample of urology clinic patients. At follow-up the men classified themselves directly in addition to answering the original series of related questions. In the present article, we report the results of a new discriminant function, based on the MMAS men at follow-up. We also compare the two methods and discuss our reasons for preferring the internally calibrated method.

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Section: Sampling and Data Collectionmentioning

confidence: 99%

A new surrogate variable for erectile dysfunction status in the Massachusetts male aging study

Kleinman

Feldman

Johannes

et al. 2000

Journal of Clinical Epidemiology

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“…4 Furthermore, the application of a testosterone replacement strategy for older men with low or low-normal testosterone levels is thought by some investigators to be especially promising for reversing such presumed 'andropausal' sequelae. 5 Yet, it has not only been difficult to correlate hormone levels with these age-related phenomena, 3,4 but testosterone replacement in elderly men is not especially effective in reversing these symptoms. 6,7 For example, although testosterone replacement in elderly men has been demonstrated to enhance upper limb strength 8,9 and mass, 7 improve bone mineral density, 6 increase hematocrit, 10 and reduce leptin levels (an effect that may improve visceral adiposity), 8 such effects are apparently weak and likely of no clinical consequence.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] Some investigators argue that age-associated testosterone deficiency, or 'andropause,' is responsible for many of the typical signs of male aging, such as erectile dysfunction (ED), decreased lean body mass, skin alterations, osteoporosis, and increased visceral fat; as well as for neuropsychiatric problems, such as fatigue, loss of libido, depression, irritability, insomnia, and memory impairment. 4 Furthermore, the application of a testosterone replacement strategy for older men with low or low-normal testosterone levels is thought by some investigators to be especially promising for reversing such presumed 'andropausal' sequelae.…”

Section: Introductionmentioning

confidence: 99%

Normative hypogonadism and depression: does ‘andropause’ exist?

Seidman

2006

Int J Impot Res

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The progressive decline in testosterone level has been demonstrated in both cross-sectional and longitudinal studies, and overall at least 25% of men over the age of 70 years meet laboratory criteria for hypogonadism (i.e., testosterone deficiency). Such age-associated HPG hypofunctioning, which has been termed 'andropause', is thought to be responsible for a variety of symptoms experienced by elderly men, including sexual dysfunction and depression. Although, it has been difficult to establish correlations between 'andropausal' symptoms and plasma testosterone levels, there is some evidence that testosterone replacement leads to improvement in muscle strength, bone mineral density, and erectile dysfunction. There is little evidence of a link between HPG-axis dysfunction and depressive illness, and exogenous androgens have not been consistently shown to be antidepressant. This article reviews the relationship between androgens and depression in aging men.

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“…1 -3 Female menopause is well understood, but there is disagreement about whether males experience a comparable 'andropause' induced by declining testosterone. 4,5 Here we evaluate hormonal and other potential causes of declining sexuality among 98 men between the ages of 50 and 80 years old, all married and none in poor health. Half our respondents live in Germany, half in the USA, allowing a check for consistency of findings across industrial cultures.…”

Section: Introductionmentioning

confidence: 99%

Causes of sexual decline in aging married men: Germany and America

et al. 2002

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Married men in Germany (n ¼ 48) and America (n ¼ 50) between 50 and 80 years old, none in poor health, provided comparable information on sexual behavior and attitudes, and gave saliva samples from which testosterone was assayed. Sexuality declines with age, as expected. Neither testosterone nor psychological depression explain levels of sexuality. In both nations, wife's desire for intercourse, subject's ability to maintain an erection, and subject's imagination about other women, explain certain aspects of sexuality. Subject's health and marital satisfaction are related to sexuality among Americans but not among Germans. Behavioral models for the two nations are compared.

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The questionable physiologic and epidemiologic basis for a male climacteric syndrome: preliminary results from the Massachusetts Male Aging Study

Cited by 75 publications

References 65 publications

A new surrogate variable for erectile dysfunction status in the Massachusetts male aging study

A new surrogate variable for erectile dysfunction status in the Massachusetts male aging study

Normative hypogonadism and depression: does ‘andropause’ exist?

Causes of sexual decline in aging married men: Germany and America

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