The Radiological and Stereological Analysis of the Effect of Low-Level Laser Therapy on the Mandibular Midline Distraction Osteogenesis

Çakır-Özkan, Nilüfer; Bereket, Cihan; Arıcı, Nursel; Elmalı, Muzaffer; Şener, İsmail; Bekar, Esengül

doi:10.1097/scs.0000000000002046

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…[36][37][38]40,46,49,51 Six studies evaluated the effect of LLLT on the activation phase of DO 39,41,44,45,47,52 and three studies evaluated the effect of LLLT on the latency and activation phases of DO. 42,43,50 However, Angeletti et al 50 did not accurately mention these two phases but the timing of laser irradiation was within these two phases. In a study by Freddo et al, one group was subjected to laser irradiation in the latency and activation phases and the other group in the consolidation phase.…”

Section: Discussionmentioning

confidence: 99%

“…In total, each patient underwent 8 sessions of laser therapy. 42 Another study reported laser irradiation in the consolidation phase at 4 points of the osteotomy site including two lateral points and 2 points in the inferior region of the body of the mandible. Laser therapy was performed for 12 sessions, each session for 2 minutes.…”

Section: The Effect Of Photobiomodulation On Domentioning

confidence: 99%

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The Effect of Photobiomodulation on Distraction Osteogenesis

et al. 2019

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Distraction osteogenesis (DO) is a surgical procedure to increase bone height in different body parts. DO includes a surgical incision, wherein the bone is cut and a device is installed for further separation of the two ends by gradual unscrewing of the device screw. New bone gradually forms and fills the gap, and the bone height increases as such. Photobiomodulation (PBM) or low-level laser therapy (LLLT) enhances the formation of soft and hard tissue such as bone and can, therefore, accelerate the process of DO and shorten the duration of different surgical phases of DO such as latency, activation, and consolidation. Different laser types with variable exposure settings and protocols have been used for this purpose. The gallium-aluminum-arsenide (GaAlAs) diode laser is the most commonly used laser type for LLLT. This study reviews 18 published articles on the effects of LLLT on DO and summarizes their findings to further elucidate this topic.

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Section: Discussionmentioning

confidence: 99%

Section: The Effect Of Photobiomodulation On Domentioning

confidence: 99%

The Effect of Photobiomodulation on Distraction Osteogenesis

et al. 2019

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“…The Cavalieri method in stereology is an effective and easily applied method used to calculate the volume of a tissue or organ. As it enables a three-dimensional evaluation, it reflects the tissue features better than histological evaluations and gives more realistic values (25). In this study, no statistically significant difference was found between the experimental groups and the control group in terms of new bone volume values.…”

Section: Discussionmentioning

confidence: 99%

The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis

et al. 2019

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Purpose:This study aims to evaluate the effects of extracorporeal shock wave therapy applied before and/or immediately after the osteotomy on the maturation during the consolidation phase.Materials and methods:21 female New Zealand rabbits were used in the study. Subjects were divided randomly into three groups: Control (Distraction without ESWT), A (Distraction +ESWT After Osteotomy), AB (Distraction+ESWT After and Before Osteotomy). ESWT (500 pulses, 5 Hz, 0.19 mJ/mm2 energy flux density) was applied to group A and group AB after 5, 12 and 19 days after osteotomy and group AB only on days 7,14 and 21 before osteotomy. On the 28th day of the consolidation period, all subjects were sacrificed. Dual-energy x-ray absorptiometry (DEXA) was used to determine bone mineral density (BMD) and bone mineral content (BMC), and stereological methods were used to determine the new bone, connective tissue and neovascularization volumes.Results:As a result of DEXA examinations made on the 1st and 4th week of consolidation, there was no significant difference between groups regarding BMD and BMC values. According to the results of stereological examination, when the connective tissue and new bone tissue were evaluated, higher values were observed in AB when compared to A, and in AB and A compared to the control group, but the differences are not statistically significant. There was no difference between the groups in terms of neovascularization.Conclusion:ESWT in these parameters was not positively effective in bone maturation during consolidation when applied before osteotomy or both before and after osteotomy.

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“…For this purpose; all rabbits were positioned with the occlusal plane perpendicular to the horizontal plane. Images were taken by HR-CT (Aquilion 16 system, Toshiba Medical System Corporation, Tochigi-ken, Japan) according to (17). Bone density values were measured twice by the same examiner.…”

Section: Methodsmentioning

confidence: 99%

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Onger¹,

Bereket²,

Şener³

et al. 2017

Med Oral

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BackgroundIn this study we examined the effects of two different repeated Extracorporeal Shock Waves (ESW) on the consolidation period of the distraction osteogenesis (DO) of the rabbit mandible using stereological, radiological and immunohistochemical methods.Material and MethodsDO was performed unilaterally in the mandible of 18 New Zealand rabbits (six months old, weighing between 2.5-3 kg). In the consolidation period, rabbits were divided into three groups randomly after the distraction period. The distraction zone of the mandible was received no treatment as controls (E0*2). Group 2 (E 500*2) received ESWT (twice 500 impulses at 14 kV and 0.19 mJ/mm2 energy) in the first and fourth days of the consolidation. Group 3 (E1000*2) treated with ESWT (twice 1000 impulses at 14 kV and 0.19 mJ/mm2 energy) in the first and fourth days of the consolidation period. After the sacrification, radiologically bone mineral density, new bone formation, new fibrous tissue and new vessel formation were analyzed by stereological.ResultsIt was found a statistically significant difference between the study groups and control group in the bone mineral density measurements and the highest value was in the E1000*2 group. In the stereological analysis, new bone formation was highest in the E1000*2 group and there was a significant difference compared to the other groups (E0*2 and E500*2) (p=0.000). The lowest connective tissue volume was found in the E500*2 and there was a significant difference compared to the other groups (E0*2 and E1000*2) (p=0.000). The volume of the new vessel was highest in the E500*2 and lowest in the E0*2 group. It was found statistically significant difference between the values of the study and control groups.ConclusionsInterestingly, we found that repetition of the 1000 impulses ESWT accelerated the consolidation, 500 impulses ESWT extended consolidation period of the DO. Key words:Distraction osteogenesis, extracorporeal shock waves, stereology, rabbit.

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The Radiological and Stereological Analysis of the Effect of Low-Level Laser Therapy on the Mandibular Midline Distraction Osteogenesis

Abstract: The retention period can be shortened and mineralization may be increased by using LLLT in mandibular distraction osteogenesis.

Cited by 8 publications

References 25 publications

The Effect of Photobiomodulation on Distraction Osteogenesis

The Effect of Photobiomodulation on Distraction Osteogenesis

The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

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