The Radioprotective Effects of Nano-Curcumin Against Genotoxicity Induced by Iodine-131 in Patients with Differentiated Thyroid Carcinoma (DTC) by Micronucleus Assay

Abstract

Background: Breast cancer is the most common cancer among women worldwide. Objectives: Regarding the effect of delay on survival in patients with breast cancer and the high incidence of delayed presentation in these patients in Iran, we decided to study the factors affecting delay in seeking treatment in patient with breast cancer in Kerman, South-east of Iran. Methods: In this cross sectional study, 80 cases (with delay time less than 3 months) and 80 controls (patients with delay time more than 3 months) were enrolled. A questionnaire including demographic characteristics, knowledge, attitude, and Health belief model (HBM) subscales was used for data collection after reliability and validity assessment. Results: The majority of the patients were housewives (73.2%) and most of the patients lived in urban areas (63.7%). The results of multivariate logistic regression showed that there was a significant relationship between the perceived barriers OR = 1.48 (CI 95% = 1.18 -1.86), cues to action OR = 0.72 (CI 95% = 0.55 -0.93), perceived susceptibility OR = 0.87 (CI 95% = 0.78 -0.97), and the first symptom OR = 0.259 (CI 95% = 0.08 -0.79) with delay in seeking treatment in patients with breast cancer. Conclusions: According to the results, health belief and knowledge about breast cancer were two important factors affecting delay in treatment seeking in patients with breast cancer in Kerman, Iran. In order to reduce this delay, appropriate health education programs should be performed.

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

“…224,246,247 It also reduced DNA damage and micronuclei formation in lymphocytes of thyroid cancer patients. 228 Moreover, the antidiabetic properties of nanocurcumin were attributed their capacity in reducing FBG, glycated Hb, insulin, hs-CRP, TC, TAC, TN, LDL-C, VLDL-C, TC/HDL-C, MDA, and augmented insulin sensitivity, TAC, peroxisome proliferator-activated receptor gamma (PPARγ), LDLR, and GSH levels in T2D patients. 248−251 It also suppressed neuropathy, depression, and anxiety in T2Dassociated peripheral neuropathy patients.…”

Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials

“…Radiation therapy triggers different cellular signaling pathways that lead to the activation of proinflammatory cytokines and thus the development of inflammatory responses 111 . One study found that the administration of 160 mg/day of nano‐curcumin to patients with differentiated thyroid cancer could prevent genetic damage in peripheral blood lymphocytes by radiation.…”

“…Radiation therapy triggers different cellular signaling pathways that lead to the activation of proinflammatory cytokines and thus the development of inflammatory responses. 111 One study found that the administration of 160 mg/day of nano-curcumin to patients with differentiated thyroid cancer could prevent genetic damage in peripheral blood lymphocytes by radiation. In this study, administration of nano-curcumin from 3 days before up to 7 days after radiation therapy prevented the increase of peripheral lymphocyte micronuclei that cause significant genotoxic damage.…”

Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders

“…The vitamin E and curcumin defense impact T4-induced oxidative stress in rats' renal cortex was reported by modulation of antioxidant enzymes and oxidative stress parameters (35). Orally administration of curcumin (160 mg/day) 3 days before and 7 days after I-131 therapy inhibited oxidative and genotoxic damage (66).…”