The Rat

Johnson, Mark D.; Gad, Shayne C.; Kemper, Christopher

doi:10.1201/b18705-4

Cited by 8 publications

(14 citation statements)

References 270 publications

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“…The control mortality rate (35.0%) is consistent with previous reported studies in the literature 51 –55 and with your own data 57 and therefore supports that this study was conducted in a suitable fashion.…”

Section: Discussionsupporting

confidence: 91%

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Long-Term (24 Months) Carcinogenicity Study of D-004, a Lipid Extract From Roystonea regia Fruits, in Sprague Dawley Rats

et al. 2015

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Section: Discussionsupporting

confidence: 91%

“…Neoplastic lesions were analyzed according to their frequency, type, and affected organ/tissue. Data were interpreted considering the spontaneous frequencies referred by other authors 51 –55 and our data. 56,57 Nonneoplastic lesions were also analyzed.…”

Section: Methodsmentioning

confidence: 99%

Long-Term (24 Months) Carcinogenicity Study of D-004, a Lipid Extract From Roystonea regia Fruits, in Sprague Dawley Rats

et al. 2015

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“…The rats were weighed and classified into 3 age groups on the basis of their body weight: immature (female: <100 g; male: <100 g), pubertal (female: 101–175 g; male: 101–200 g), and postpubertal (female: >175 g; male: >200 g; Table 1). 19 The wild rats were euthanized and autopsied, and location, number, and size of cysts together with the length of larvae were recorded. Following gross examination, all major parenchymal organs including the organs that contain cysts were fixed in 10% neutral buffered formalin, processed routinely for paraffin embedding, sectioned at 4 μm thickness, and stained with hematoxylin and eosin (HE).…”

Section: Methodsmentioning

confidence: 99%

Cysticercus fasciolaris infection in wild rats (Rattus norvegicus) in Korea and formation of cysts by remodeling of collagen fibers

et al. 2016

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Abstract. Cysticercus fasciolaris, the larval form of Taenia taeniaeformis, is commonly encountered in rodents. In our study, 287 wild rats (Rattus norvegicus) in South Korea were examined in 2010 and 2011. Of 287 rats, 97 (33.8%) were infected with C. fasciolaris. A strong positive correlation was found between the host body weight and prevalence in both sexes, regardless of the year of collection. The liver was the most common habitat of the parasite, and the lung was the most frequent ectopic region, followed by mesentery, pleura, abdominal wall, and kidney. The lesions of the affected organs were generally characterized by well-developed cysts, each containing a larva. However, the cysts within kidney and abdominal wall were poorly organized, filled with abscess, and lacked larvae. Collagen types I and III, but not type IV, played significant roles in constructing the cysts at differential stages, addressed by immunohistochemistry. During cyst wall development, both collagen types contributed equally to cyst formation at the early stage, whereas collagen type I was the major component at the late stage (p < 0.05). In early-stage cysts, distribution of collagens was interestingly differential depending on the development stage, as collagen type I was localized in the outer layer and type III was located in the inner layer. Our results suggest that an appropriate remodeling process of collagen fibers is necessary for C. fasciolaris to build the well-conditioned cysts in the target organs for survival.

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“…We also observed several gross and histological lesions in the current work that occurred in both controls and treated animals without dose-responses. Renal pelvic dilatation is a species-specific background lesion that occurs in untreated rats [ [53] , [54] , [55] , [56] , [57] ] and historical control animals of the laboratory, and uterine dilatation (which can be indicative of an estrogenic effect of a test item when a dose-response, degenerative changes, and/or other correlating findings are observed) is a normal occurrence during the proestrus and estrus phases of the sexual cycle due to stimulation by estrogen [ [58] , [59] , [60] , [61] ].…”

Section: Discussionmentioning

confidence: 99%