The Rat With Oxygen-Induced Retinopathy Is Myopic With Low Retinal Dopamine

Zhang, Nan; Favazza, Tara L.; Baglieri, Anna Maria; Benador, Ilan Y.; Noonan, Emily R.; Fulton, Anne B.; Hansen, Ronald M.; Iuvone, P. Michael; Akula, James D.

doi:10.1167/iovs.13-12544

Cited by 24 publications

(31 citation statements)

References 87 publications

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“…Thus, the control of eye growth is almost entirely a local phenomenon (Smith, 2011; Smith et al, 2013; Wallman et al, 1987; Wildsoet and Schmid, 2000). Our studies of refractive development in a rat model of ROP elegantly recapitulate our human findings of delayed growth, including of the anterior segment (Chui et al, 2012a; Zhang et al, 2013). If the neural retina controls eye growth, the abnormally avascular peripheral ROP retina may, therefore, underpin some of the abnormalities in the ROP eye, especially of the posterior segment.…”

Section: Eye Growth and Refractive Developmentsupporting

confidence: 76%

“…In any event, the short-eyed myopia found in the ROP rat offer insights about ocular development that cannot be obtained using traditional models of induced ametropia. For example, we have found that dopamine levels are low in ROP eyes, despite their being short (Zhang et al, 2013) and note the long-recognized role of dopamine as a “stop-signal” for eye growth (Iuvone et al, 1991). …”

Section: Eye Growth and Refractive Developmentsupporting

confidence: 52%

“…The myopia both in the children and rat model (Chui et al, 2012a; Zhang et al, 2013) have led to the term “small eye myopia”. The ROP posterior segment and sclera grows much less than expected for the degree of myopia (Chui et al, 2012a; O’Connor et al, 2006; Zhang et al, 2013). As reviewed above, the choroid in the rat model of ROP and also in human ROP is too thin.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

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The neural retina in retinopathy of prematurity

Hansen

Moskowitz

Akula

et al. 2017

Progress in Retinal and Eye Research

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Retinopathy of prematurity (ROP) is a neurovascular disease that affects prematurely born infants and is known to have significant long term effects on vision. We conducted the studies described herein not only to learn more about vision but also about the pathogenesis of ROP. The coincidence of ROP onset and rapid developmental elongation of the rod photoreceptor outer segments motivated us to consider the role of the rods in this disease. We used noninvasive electroretinographic (ERG), psychophysical, and retinal imaging procedures to study the function and structure of the neurosensory retina. Rod photoreceptor and post-receptor responses are significantly altered years after the preterm days during which ROP is an active disease. The alterations include persistent rod dysfunction, and evidence of compensatory remodeling of the post-receptor retina is found in ERG responses to full-field stimuli and in psychophysical thresholds that probe small retinal regions. In the central retina, both Mild and Severe ROP delay maturation of parafoveal scotopic thresholds and are associated with attenuation of cone mediated multifocal ERG responses, significant thickening of post-receptor retinal laminae, and dysmorphic cone photoreceptors. These results have implications for vision and control of eye growth and refractive development and suggest future research directions. These results also lead to a proposal for noninvasive management using light that may add to the currently invasive therapeutic armamentarium against ROP.

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Section: Eye Growth and Refractive Developmentsupporting

confidence: 76%

Section: Eye Growth and Refractive Developmentsupporting

confidence: 52%

Section: Summary and Future Directionsmentioning

confidence: 99%

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The neural retina in retinopathy of prematurity

Hansen

Moskowitz

Akula

et al. 2017

Progress in Retinal and Eye Research

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“…Retinal function was assessed by electroretinography (ERG) as previously described 27 in P30 untreated WT mice and…”

Section: Ergmentioning

confidence: 99%

Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy

Wang

Liu

Sun

et al. 2016

The American Journal of Pathology

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“…на крысиной модели и Spix с соавт. на мышиной модели РН выявили снижение содержания ДА и его метаболита (ДОФУК) в сетчатке животных с РН [7,8]. Авторам удалось доказать, что на их моделях дефицит ДА L-ДОФА.…”

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The role of catecholamines in the development of pathological retina neovascularization in an experimental model of retinopathy of prematurity in rats

Катаргина

Osipova

Panova

et al. 2019

Доклады Академии наук

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This work is dedicated to prove our hypothesis that catecholamines and their metabolites play crucial role in development of retinopathy of prematurity, severe disabling fibrovasoproliferative vitreoretinal pathology of premature infants. Research was done on experimental model of retinopathy achieved by hyperohygenation in rats on 7th, 14th, 21st and 30th day of life. Amount of catecholamines and their metabolites in retina of rats was measured by HPLC with electrochemical detection. It was shown that L-DOPA on 21st and 30th day of life were lowered in model animals than in control and noradrenaline on 14 th day increased in model animals than in control. However we did not observed dopamine changes between experimental model and control. Given the literature data on cathecholamines and their role in regulation of vasculogenesis in retina, our data shows that changes in cathecholamine metabolism play crucial role in pathology of this severe illness.

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The Rat With Oxygen-Induced Retinopathy Is Myopic With Low Retinal Dopamine

Abstract: The OIR rat is the first known animal model of myopia in which the eye is smaller than normal. Dopamine may modulate, or fail to modulate, neural activity in the OIR eye, and thus contribute to this peculiar myopia.

Cited by 24 publications

References 87 publications

The neural retina in retinopathy of prematurity

The neural retina in retinopathy of prematurity

Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy

The role of catecholamines in the development of pathological retina neovascularization in an experimental model of retinopathy of prematurity in rats

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