The Rate of Aging of the &amp;lt;i&amp;gt;Dunaliella viridis&amp;lt;/i&amp;gt; Teodor. Culture Depends on the Algae Pre-Adaptation to Copper Sulfate Toxic Effect

Божков, А. И.; Kovaleva, M.K.; Menzyanova, N. G.; Kuznetsova, Yu. A.

doi:10.4236/aar.2014.32027

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Our previous data can explain the influence of CR diet on the formation of specific epigenotype associated with lifespan [9] and can also explain the influence of the pre-adaptation on the lifespan of cell cultures [7].…”

Section: Discussionmentioning

confidence: 69%

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Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Ai¹,

Yu²

2016

J Gerontol Geriatr Res

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We investigated the role of metabolic memory in a choice of strategies for adaptation to stress influences. We used a model of rat overeating in early ontogenesis from birth to 21 days of life and investigated the maintenance of formed metabolic pattern in later ontogenesis.The following characteristics were measured: somatometric indicators, resistance of animals to a temperature stress of 32ᵒC, thyroxin and triiodothyronine content in blood serum, NO-synthase activity, the content of lipid hydroperoxides and antioxidant enzymes in different organs in animals of 3, 20 and 31 months of age under standard conditions of maintenance in control animals and after overeating in the early ontogenesis.It is shown that the metabolic pattern formed on the background of overeating from birth to 21 days remains until the later stages of ontogeny. The forming metabolic pattern is characterized by elevated content of thyroxin, increase of NO-synthase activity in various tissues and particularly in the brain, a small increase of lipid hydroperoxides and reduced antioxidant activity of some enzymes. Animals that overeated in the early ontogenesis, are characterized by lower resistance to high temperatures and shorter life expectancy compared to the animals contained in the standard terms.

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Section: Discussionmentioning

confidence: 69%

“…Formed interrelated metabolic cycles can be self-sustaining for a long time, i.e. can be stored and can influence the further choice of adaptation strategies [7].…”

Section: Introductionmentioning

confidence: 99%

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Ai¹,

Yu²

2016

J Gerontol Geriatr Res

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The “Mix-Factor” is involved in the regulation of the organism's redox systems in the late stages of ontogenesis and affects the lifespan of animals

Божков¹,

Ivanov²,

Klimova³

et al. 2021

A&L

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the content of lipid hydroperoxides in the serum and liver mitochondria in animals in the late stages of ontogenesis (12 and 33 months old, Wistar male rats) was investigated. The possible effect of the food additive (“mix factor”) on these parameters in 33 months old animals, if they received this supplement from 22 months age daily throughout life in a dose of 0.05 - 0.06 ml / 100 g of body weight was determined. Moreover, the lifespan of animals was determined if they started taking a mix – factor from 22 months and from 30.5 months age. The influence of the mix – factor on the ability of old animals to perform work was determined in a separate series of experiments. It was shown that from 22 to 33 months the content of lipid hydroperoxides in mitochondria and serum increased by 23% and 41%, respectively. The activity of glutathione peroxidase in the serum, mitochondria and erythrocytes decreased, and the activity of glutathione reductase decreased only in the post-mitochondrial fraction of the liver. At the same time, malate– isocitrate dehydrogenase and 6-phosphate dehydrogenase remained unchanged in 33 months old animals compared with 12 months old animals. If animals from 22 months age received a mix factor with drinking water in a dose of 0.05-0.06 mg / 100 g of body weight every day until the end of life, the content of lipid hydroperoxides and the activity of glutathione peroxidase and glutathione reductase of 33 months old animals did not differ from 12 months old animals. The survival curve in animals receiving the mix factor was shifted to the right from 25 to 28 months of age compared with the survival curve of control animals. If animals began to receive the mix – factor at a very old age (from 30.5 months age) until the end of life, their lifespan was longer than that of the control animals. The last ones lived to 41 months, while the animals of the control group lived to 36 months. At the same time, the mix – factor increased the ability of old animals to do work in the test “running in treadmill”. Key words: aging, redox-system, geroprotectors, lifespan

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Do we get sick because we are getting old, or do we get old and therefore get sick? Kharkiv Gerontological School - eighty years later

Bozhkov

2024

A&L

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Abstract. Interest in understanding the ageing processes has always existed. The choice of methods for investigating the mechanisms of this fundamental biological phenomenon is determined by the general development of the methodology of biological and medical research. The study of highly dynamic self-organising biological systems developed along the inevitable path of reductionism, which contributed to the discovery of various stages of molecular processes and the formation of such new areas as a set of -omic sciences (genomics, transcriptomics, lipidomics, etc.). The success in understanding the molecular mechanisms of biological systems' functioning led to the realisation of the impossible complexity of integrating private mechanisms into a unified whole, particularly in the development processes and ageing as the final stage of ontogenesis. In the author's opinion, this situation has led to low efficiency of cognition of ageing processes. In this respect, it is reasonable to recall and make a retrospective analysis of the research results of one of the oldest gerontological scientific schools, such as the Kharkiv ontophysiological school of A.V. Nagorny. The review gives the characteristics of the scientific school, the stages of its formation, and the creative environment at the Kharkiv University of the 19th century, based on which the scientific school of A.V. Nagorny was formed.

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The Rate of Aging of the <i>Dunaliella viridis</i> Teodor. Culture Depends on the Algae Pre-Adaptation to Copper Sulfate Toxic Effect

Cited by 3 publications

References 20 publications

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

Overeating in Early Postnatal Ontogenesis Forms Metabolic Memory and Reduces Lifespan

The “Mix-Factor” is involved in the regulation of the organism's redox systems in the late stages of ontogenesis and affects the lifespan of animals

Do we get sick because we are getting old, or do we get old and therefore get sick? Kharkiv Gerontological School - eighty years later

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