The rate of osteoclastic bone erosion in Haversian remodeling sites of adult dog's rib

Jaworski, Z; Lok, E.

doi:10.1007/bf02012540

Cited by 76 publications

(41 citation statements)

References 11 publications

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“…These abnormalities are similar to those visible in patients with metabolic osteoporosis. High signal intensity depicted on T2-weighted MR images within striations and resorption cavities may be well explained by cell accumulation (osteoclasts, osteoblasts, and fibroblastic cells), increased amount of blood vessels, and production of connective tissue and osteoid matrix, which all occur in osteoporotic bone (8,50). In addition, stress leads to numerous microscopic intracortical microcracks (8) that probably result in hemorrhage and edema.…”

Section: Discussionmentioning

confidence: 97%

CT and MR Imaging Findings in Athletes with Early Tibial Stress Injuries: Comparison with Bone Scintigraphy Findings and Emphasis on Cortical Abnormalities

Gaeta¹,

Minutoli²,

Scribano³

et al. 2005

Radiology

277

178

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Section: Discussionmentioning

confidence: 97%

CT and MR Imaging Findings in Athletes with Early Tibial Stress Injuries: Comparison with Bone Scintigraphy Findings and Emphasis on Cortical Abnormalities

Gaeta¹,

Minutoli²,

Scribano³

et al. 2005

Radiology

277

178

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show abstract

“…The fiber radius a 0 and the fiber spacing ∆ were taken as a 0 = 0.6 nm and ∆ = 7 nm (Weinbaum et al, 1994). The maximum remodeling rateṀ max = 40 µm/day (Jaworski and Lok, 1972) was based on the resorption rate of osteoclasts. The maximum distance for intercellular communication l L was set to l L = 200 µm, referring to the in vitro experiment involving the observation of the propagation of calcium signaling between bone cells (Huo et al, 2008;Adachi et al, 2009c).…”

Section: Voxel Modeling Of a Single Trabeculamentioning

confidence: 99%

Effects of loading frequency on the functional adaptation of trabeculae predicted by bone remodeling simulation

Kameo

Adachi

Hojo

2011

Journal of the Mechanical Behavior of Biomedical Materials

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The process of bone remodeling is regulated by metabolic activities of many bone cells. While osteoclasts and osteoblasts are responsible for bone resorption and formation, respectively, activities of these cells are believed to be controlled by a mechanosensory system of osteocytes embedded in the extracellular bone matrix. Several experimental and theoretical studies have suggested that the strain-derived interstitial fluid flow in lacuno-canalicular porosity serves as the prime mover for bone remodeling. Previously, we constructed a mathematical model for trabecular bone remodeling that interconnects the microscopic cellular activities with the macroscopic morphological changes in trabeculae through the mechanical hierarchy. This model assumes that fluid-induced shear stress acting on osteocyte processes is a driving force for bone remodeling. The validity of this model has been demonstrated with a remodeling simulation using a two-dimensional trabecular model. In this study, to investigate the effects of loading frequency, which is thought to be a significant mechanical factor in bone remodeling, we simulated morphological changes of a three-dimensional single trabecula under cyclic uniaxial loading with various frequencies. The results of the simulation show the trabecula reoriented to the loading direction with the progress of bone remodeling. Furthermore, as the imposed loading frequency increased, the diameter of the trabecula in the equilibrium state was enlarged by remodeling. These results indicate that our simulation model can successfully evaluate the relationship between loading frequency and trabecular bone remodeling.

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“…These states were extracted from a previous analysis of the proximal head of a human femur, by Doblaré and García (2002), selecting arbitrarily three points with different densities. The values used for the parameters defined in the model have been taken from the literature (Whalen and Carter 1988;García-Aznar et al 2005;Hazelwood et al 2001;Jaworski and Lok 1972;Parfitt et al 1996;Hernandez 2001) and are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

A bone remodelling model including the directional activity of BMUs

Martínez-Reina

García-Aznar

Domı́nguez

et al. 2008

Biomech Model Mechanobiol

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Bone is able to adapt itself to the mechanical and biological environment by changing its porosity and/or orientation of its internal microstructure in a process known as bone remodelling. As a consequence, a change of bone mechanical properties is produced leading to an optimum structure, able to bear the external loads with the minimum weight. This adaptation is carried out by a temporal association of cells known as BMUs (basic multicellular units) that resorb old bone and sometimes produce new organic extracellular matrix (osteoid) that is later mineralized. This involves changes in porosity, damage level (density of microcracks accumulated by cyclic loads) and mineral content. All of these features were taken into account in a previous model, but the whole process and therefore the resulting bone constitutive behaviour was considered isotropic. The model proposed herein, recognizing that bone is actually anisotropic, tries to explain how BMUs modify the anisotropy by changing their progressing direction. We check the potential of the model to predict the alignment of the bone microstructure with the external loads in different situations. Then, the model is also applied to obtain the anisotropy and mechanical properties of the human proximal femur under physiological loads with initial conditions corresponding to a heterogeneous, but otherwise isotropic bone.

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The rate of osteoclastic bone erosion in Haversian remodeling sites of adult dog's rib

Cited by 76 publications

References 11 publications

CT and MR Imaging Findings in Athletes with Early Tibial Stress Injuries: Comparison with Bone Scintigraphy Findings and Emphasis on Cortical Abnormalities

CT and MR Imaging Findings in Athletes with Early Tibial Stress Injuries: Comparison with Bone Scintigraphy Findings and Emphasis on Cortical Abnormalities

Effects of loading frequency on the functional adaptation of trabeculae predicted by bone remodeling simulation

A bone remodelling model including the directional activity of BMUs

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