The Rate of Respiration and Glycolysis by Human and Dog Aortic Tissue

Kirk, J. E.; Effersoe, P; Chiang, Shih-Wen

doi:10.1093/geronj/9.1.10

Cited by 80 publications

(10 citation statements)

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“…Lactate was the major product of arterial glucose metabolism in both control and diabetic arteries and represented greater than 80~ of the total glucose utilized. These findings are comparable to those reported for arteries of a number of different species including man [22--26] and probably reflect the relatively high rate of glycolysis and low rate of mitochondrial oxidation in arterial tissue [27].…”

Section: Discussionsupporting

confidence: 89%

Aortic glucose metabolism in the diabetic Chinese hamster

Chobanian¹,

Gerritsen

Brecher

et al. 1974

Diabetologia

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Summary. The influence of diabetes and insulin therapy on arterial glucose metabolism was studied in the Chinese hamster. Total glucose utilization and eonversion of glucose to lactic acid, CO s, lipid, glycogen, and protein were significantly reduced in intima-media segments of diabetic hamster aorta incubated in vitro. The degree of reduction was greater in the kctotic than the non-ketotie diabetics. The abnormalities in glucose metabolism did not appear to be related to a defect in glucose transport. Administration of insulin in vivo for up to 72 h in doses sufficient to normalize plasma glucose and insulin did not influence aortic glucose utilization. However, treatment with large doses of insulin, which produced marked hyperinsulinemia and mild hypoglycemia, corrected the observed reductions in glucose incorporation. Addition of insulin in vitro had no significant effect on aortic glucose metabolism.

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Section: Discussionsupporting

confidence: 89%

Aortic glucose metabolism in the diabetic Chinese hamster

Chobanian¹,

Gerritsen

Brecher

et al. 1974

Diabetologia

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“…In view of past evidence that a considerable amount of the energy required by the arterial wall could be derived froml glycolysis (2,4), the level of oxygenation necessary to maintain cellular processes adequately has been unclear. Recent evidence suggests that aerobic metabolism meets a larger percentage of the energy requirement of the wall than earlier references indicated (5).…”

Section: Introductionmentioning

confidence: 99%

In vivo oxygen transport in the normal rabbit femoral arterial wall.

Crawford¹,

Back²,

Cole³

1980

J. Clin. Invest.

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“…The overall average is also reQoi (in mm. 8 t-test for significant deviation of the average potential difference value from zero for each blood vessel wall segment was carried out. It was found both for aorta and A' ena cava that the measurements were not significantly different from zero at the 0.1 per cent level.…”

Section: Resultsmentioning

confidence: 99%

“…for the aorta and vena cava is 0.62 and 0.59 mm. 8 ±25 ±31 ±26 ±30 ±31 ±27 ±23 ±29 ±32 tMenn potential difference = +11.8 /iv. Average error of mean potential difference = ±50.7 n\r.…”

Section: Discussionmentioning

confidence: 98%