The rates of quinolone, trimethoprim/sulfamethoxazole and aminoglycoside resistance among Enterobacteriaceae isolated from urinary tract infections in Azerbaijan, Iran

Yekani, Mina; Baghi, Hossein Bannazadeh; Sefidan, Fatemeh Yeganeh; Azargun, Robab; Memar, Mohammad Yousef; Ghotaslou, Reza

doi:10.3205/dgkh000313

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…However, the emergence of high levels of resistance of uropathogenic E. coli against trimethoprim/sulfamethoxazole has been reported in both developing countries (54 -82%) and developed countries (14.6 -37.1%) (28)(29)(30). The present study also discovered an elevated resistance rate to trimethoprim/sulfamethoxazole (54.1%), which is in accordance with other Iranian studies (19,24,31). According to these results, trimethoprim-sulfamethoxazole should no longer be used as the primary empirical treatment in Iran.…”

Section: Discussionsupporting

confidence: 92%

A Retrospective Cross-sectional Study on Prevalence and Susceptibility Pattern of Bacterial Pathogens Causing Urinary Tract Infections at a Teaching Hospital in Tehran, Iran

Noori

Aghamohammad

Ashrafian

et al. 2023

Arch Pediatr Infect Dis

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Background: Urinary tract infection (UTI) is the most prevalent infection among the community and hospitalized patients. Objectives: This study aimed to investigate the current antimicrobial susceptibility patterns among UTI agents in Tehran, Iran. Methods: This retrospective study analyzed 9836 urine samples collected from hospitalized patients within 2019 - 2020. The antibiotic susceptibility for commonly-used antibiotics was tested according to Clinical and Laboratory Standards Institute guidelines. Results: Based on the findings, Escherichia coli was the most prevalent etiological agent of UTIs (72.3%), followed by Klebsiella spp. (13.4%), Pseudomonasaeruginosa (4.8%), Acinetobacter spp. (2.8%), and other species (6.7%). Of isolated microorganisms, 943 cases (97%) belonged to Gram-negative bacilli; however, 32 cases (3.05 %) were Gram-positive cocci. The susceptibility rates of E. coli to amikacin, nitrofurantoin, gentamicin, imipenem, and cefoperazone were 88.4%, 87.5%, 68.3%, 65.9%, and 62.6%, respectively. The sensitivity rates of Klebsiella spp. isolates for amikacin, nitrofurantoin, and imipenem were 87.6%, 71.5%, and 68.9%, respectively. Conclusions: The results of the present study characterized the misuse of antibiotics in Iran. Iranian surveillance studies will assist clinicians in choosing the most appropriate empirical treatment and preventing infections caused by resistant organisms.

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Section: Discussionsupporting

confidence: 92%

A Retrospective Cross-sectional Study on Prevalence and Susceptibility Pattern of Bacterial Pathogens Causing Urinary Tract Infections at a Teaching Hospital in Tehran, Iran

Noori

Aghamohammad

Ashrafian

et al. 2023

Arch Pediatr Infect Dis

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“…Quinolone antimicrobial resistance can be conveyed by other plasmid resistance genes that can codify for a mutant aminoglycoside modifying enzyme (AME), thus conferring resistance to both of the antimicrobial classes simultaneously [ 6 , 8 ]. Several studies have evaluated the simultaneous presence of quinolone resistance and aminoglycoside resistance in Enterobacteriaceae , particularly, against amikacin [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistant E. coli in Pork and Wild Boar Meat: A Risk to Consumers

Rega

Andriani

Cavallo

et al. 2022

Foods

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Antimicrobial-resistant foodborne microorganisms may be transmitted from food producing animals to humans through the consumption of meat products. In this study, meat that was derived from farmed pigs and wild boars was analyzed and compared. Escherichia coli (E. coli) were isolated and tested phenotypically and genotypically for their resistance to quinolones, aminoglycosides and carbapenems. The co-presence of AMR-associated plasmid genes was also evaluated. A quinolone AMR phenotypic analysis showed 41.9% and 36.1% of resistant E. coli derived from pork and wild boars meat, respectively. A resistance to aminoglycosides was detected in the 6.6% of E. coli that was isolated from pork and in 1.8% of the wild boar meat isolates. No resistant profiles were detected for the carbapenems. The quinolone resistance genes were found in 58.3% of the phenotypically resistant pork E. coli and in 17.5% of the wild boar, thus showing low genotypic confirmation rates. The co-presence of the plasmid-related genes was observed only for the quinolones and aminoglycosides, but not for the carbapenems. Wild boar E. coli were the most capable to perform biofilm production when they were compared to pork E. coli. In conclusion, the contamination of pork and wild boar meat by AMR microorganisms could be a threat for consumers, especially if biofilm-producing strains colonize the surfaces and equipment that are used in the food industry.

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“…Higher rates have been described in other studies. In Iran the resistance rate was 47.9% for tobramycin, 39.3% for kanamycin, and 27.8% for gentamicin (Yekani et al, 2018) and in India the rate was 31% for all aminoglycosides (Mardourian et al, 2023). In Nigeria, the study conducted among pediatric population found 96.9% of resistance to kanamycin (Oli et al, 2019).…”

Section: Discussionmentioning

confidence: 97%

Resistance profile of urine isolate enterobacteral strains at Donka University teaching hospital in Conakry, Guinea

Djiba,

Ousmane,

Issiaga

et al. 2024

Afr. J. Microbiol. Res.

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The objective of this study was to describe the resistance profile of enterobacterals isolated from urine samples at the laboratory of Donka National Hospital. Urine samples were collected from both outpatients and hospitalized patients. Cultures were performed using standard techniques, strains were identified using the API 20E kit, and antibiotic susceptibility testing was carried out using the ATB™ UR EU (08) kit. The results were interpreted according to the recommendations of the Antibiogram Committee of the French Society of Microbiology (CASFM v1 2023). Out of a total of 520 urine samples analyzed, 111 were positive for enterobacteral strains. Among them, 75 (67.57%) were of community origin. Escherichia coli was the most represented species (n=61, 55%), followed by Klebsiella pneumoniae (n=24, 22%). The resistance of E. coli strains to third generation cephalosporins (TGC) varied from 5.41% (n=6) to 25.23% (n=28) in the community and from 13 to 38% in the hospital. The profile for carbapenems was categorized as "susceptible to high dosage (SHP)," accounting for 16.22% (n=18). This study provided insight into the resistance profile to antibiotics used in urinary tract infections. The increasing resistance to carbapenems poses a threat to the management of strains producing extended-spectrum beta-lactamases (ESBL). It would be important to strengthen resistance surveillance in this context.

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The rates of quinolone, trimethoprim/sulfamethoxazole and aminoglycoside resistance among Enterobacteriaceae isolated from urinary tract infections in Azerbaijan, Iran

Cited by 6 publications

References 27 publications

A Retrospective Cross-sectional Study on Prevalence and Susceptibility Pattern of Bacterial Pathogens Causing Urinary Tract Infections at a Teaching Hospital in Tehran, Iran

A Retrospective Cross-sectional Study on Prevalence and Susceptibility Pattern of Bacterial Pathogens Causing Urinary Tract Infections at a Teaching Hospital in Tehran, Iran

Antimicrobial Resistant E. coli in Pork and Wild Boar Meat: A Risk to Consumers

Resistance profile of urine isolate enterobacteral strains at Donka University teaching hospital in Conakry, Guinea

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