The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function

Abstract

The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance.

The Ratio of Estimated Average Glucose to Fasting Plasma Glucose Level Is Superior to Glycated Albumin, Hemoglobin A1c, Fructosamine, and GA/A1c Ratio for Assessingβ-Cell Function in Childhood Diabetes

“…In our study, the GA/A1c ratio showed a negative correlation with the HOMA- β level but showed no significant correlations with HOMA-IR and C-peptide levels. Our data support the results of Kim et al [16], which disclosed that the GA/A1c ratio was significantly associated with HOMA- β and BMI, but not with HOMA-IR. These discrepancies may reflect the differences in patient populations, the severity of disease, the glucose tolerance status, and the degree of obesity among the studies.…”

“…Homeostasis model assessment of β -cell function (HOMA- β ) and insulin resistance (HOMA-IR) was determined by a HOMA2 calculator to assess the basal β -cell function and insulin resistance in patients with T2DM [16]. BMI was calculated as weight in kilograms divided by the square of the height in meters.…”

1,5-Anhydroglucitol Is Associated with Early-Phase Insulin Secretion in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus

“…The research abroad made a comparison between patients with type 1 diabetes mellitus and T2DM, both of whom had similar HbA1c levels, and found that patients with type 1 diabetes mellitus exhibited a significantly higher GA level. 8 The prominent glucose fluctuation resulting from insulin secretion deficiency in patients with type 1 25 Meanwhile, a study from Japan found that HOMA-b, but not HOMA-IR, was independently correlated with GA. 11 In the present study, the correlation between GA and HOMA-b was more pronounced than the correlation between GA and HOMA-IR. With focus on the mechanism, Song et al 26 uncovered the result that GA gave rise to pancreatic b-cell death by suppressing autophagy induction and flux, leading to nuclear factor-jB(p65)-inducible nitric oxide synthase-caspase-3 cascade activation, as well as by increasing susceptibility to both endoplasmic reticulum stress and oxidative stress.…”

Serum glycated albumin as a new glycemic marker in pediatric diabetes

“…Fructosamine has been known to reflect the degree of hyperglycemia over 2-3 weeks in diabetes, whereas it is affected by serum albumin concentration16-18). GA is the similar to fructosamine excluding it is not affected by serum albumin level, because it is expressed as a percentage of serum albumin13). GA assay can get to be available method in commercial laboratories for clinical application in Korea.…”

“…The high GA/HbA1c ratio may reflect recent fluctuations in glucose levels and indicated recently increased postprandial glucose levels. There have also been accumulating evidences that the GA/HbA1c ratio is more associated with postprandial plasma glucose levels and insulin secretory function than HbA1c13,14). However, studies for GA and GA compared to HbA1c in pediatric diabetes have rarely been reported.…”