The ratio of monocyte frequency to HDL cholesterol level as a predictor of asymptomatic organ damage in patients with primary hypertension

Aydin, Emel; Ateş, İhsan; Arikan, Mehmet Fettah; Yılmaz, Nisbet; Dede, Fatih

doi:10.1038/hr.2017.36

Cited by 49 publications

(42 citation statements)

References 26 publications

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“…AOD, that is, carotid intima media thickness, left ventricular mass index, urinary protein levels, and urinary albumin levels (Aydin, Ates, Fettah arikan, Yilmaz, & Dede, 2017). Elevated values of MHR were found in newly diagnosed untreated hypertensive patients when compared with healthy subjects; MHR levels correlated positively with the aortic stiffness index (r = 0.294) and negatively with aortic distensibility (r = −0.281).…”

mentioning

confidence: 93%

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Ganjali

Gotto

Ruscica

et al. 2018

Journal Cellular Physiology

219

188

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Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. Inflammation not only is a local response but can also be considered as a systemic process followed by an elevation of inflammatory mediators. Monocytes are a major source of proinflammatory species during atherogenesis. In atherosclerosis, modified low-density lipoproteins (LDLs) are removed by macrophages; these are recruited in the vessel wall, inducing the release of inflammatory cytokines in inflamed tissue. Hence, inflammatory cholesterol ester-loaded plaque is generated. High-density lipoprotein-cholesterol (HDL-C) exhibits antiatherosclerotic effects by neutralizing the proinflammatory and pro-oxidant effects of monocytes via inhibiting the migration of macrophages and LDL oxidation in addition to the efflux of cholesterol from these cells. Furthermore, HDL plays a role in suppressing the activation of monocytes and proliferation-differentiation of monocyte progenitor cells. Thus, accumulation of monocytes and reduction of HDL-C may participate in atherosclerosis and cardiovascular diseases (CVD). Given that the relationship between the high number of monocytes and low HDL-C levels has been reported in inflammatory disorders, this review focused on understanding whether the monocyte-to-HDL ratio could be a convenient marker to predict atherosclerosis development and progression, hallmarks of CV events, instead of the individual monocyte count or HDL-C level.

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mentioning

confidence: 93%

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Ganjali

Gotto

Ruscica

et al. 2018

Journal Cellular Physiology

219

188

View full text Add to dashboard Cite

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“…MHR value was positively correlated with systolic and diastolic BP and serum glucose in our study. Similarly, Aydin et al reported that MHR value was observed to be increased in asymptomatic organ damage in primary hypertension (40).…”

Section: Discussionmentioning

confidence: 81%

“…Previous studies have showed that an elevated value of MHR correlated with the features of asymptomatic organ damage such as CIMT (40) and, aortic stiffness index (39). Inconsistence to this result, we observed that MHR value was not related to CIMT in patients with adrenal tumors.…”

Section: Discussionmentioning

confidence: 95%

Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

Beysel

Çalışkan

Kızılgül

et al. 2019

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Monosit sayısının HDL-Kolesterole oranı (MHO), kardiyovasküler hastalığı olan hastalarda yüksek bulunmuş ve kardiyovasküler risk faktörleri için belirteç olduğu gösterilmiş. Fonksiyonel adrenal tümör ve fonksiyonel olmayan adrenal adenomlu hastalarda bile kardiyovasküler hastalık riski artmaktadır. Bu çalışmada ilk olarak, MHO'nun adrenal tümörlü hastalarda yüksek olup olmadığı ve kardiyometabolik risk faktörleri ile ilişkisi araştırıldı. GEREÇ VE YÖNTEM: Çalışmaya fonksiyonel adrenal tümürü olan 24 hasta (10 Cushing sendromu, 12 feokromositoma ve 2 primer hiperaldosteronizm), fonksiyonel olmayan adrenal adenomlu hasta (n=33) ve kontrol olgusu (n=50) alındı. Antropometrik inceleme, hormon ve biyokimyasal sonuçlar, lipid paneli, açlık kan şekeri (AKŞ), kan basıncı (KB), tam kan sayımı, C-reaktif protein (hs-CRP) ve karotis intima-media kalınlığı (KIMK) karşılaştırıldı. BULGULAR: Ortalama yaş (51.14±2.03'e karşın 54.01±9.37 yıl), cinsiyet dağılımı (kadın 66.7 %'a karşın 73.8 %) ve vücut kitle indeksi (31.12±3.38'a karşın 30.46±2.96 kg/m2) adrenal tümör ve kontrol grubu arasında benzerdi (sırasıyla, p>0.05). MHO değeri fonksiyonel tümör grubunda, fonksiyonel olmayan adenom ve kontrol grubuna göre, yüksek bulundu (13.79±3.14, 10,19±2,84 vs 10.08±1.82, sırasıyla, p<0.05). MHO değeri fonksiyonel olmayan adenom ve kontrol grubu arasında benzer bulundu (p>0,05). MHO değeri sistolik KB (r=0.480; p<0.001), diyastolik KB (r=0.452; p<0.001), AKŞ (r=0.333; p=0.001), hs-CRP (r=0.538, p=0.001) ve idrar normetanefrin düzeyi (r=0.302; p=0.043) ile pozitif korele idi. Kardiyovasküler hastalığı olan fonksiyonel adrenal tümörlü hastalarda, kardiyovasküler hastalığı olmayan fonksiyonel adrenal tümörlü hastalara göre, MHR değeri yüksek bulundu (14.69±2.67'e karşın 11.84±2.57, p<0.05). SONUÇ: Monosit sayısının HDL-Kolesterole oranı fonksiyonel adrenal tümörlü hastalarda yüksek bulunurken; fonksiyonel olmayan adenomlu hastalarda yüksek değildi. Monosit sayısının HDL-Kolesterole oranı kardiyometabolik risk faktörleri olan AKŞ, KB ve hs-CRP ile korele idi. Monosit sayısının HDL-Kolesterole oranı, fonksiyonel adrenal tümörlü hastalarda kardiyovasküler risk faktörleri için prediktif belirteç olabilir.

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“…As MHR is an inexpensive and readily available parameter, it has become more widely used in recent years, and has been related to several clinical conditions (13)(14)(15)(16). The relationship between OSAS and MHR was first investigated by Atan et al in 2007, and it was determined that MHR could be a predictive marker in OSAS diagnosis (17).…”

Section: Discussionmentioning

confidence: 99%

The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome

Acat¹,

Yazici²

2018

meandros

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Objective: Obstructive sleep apnea syndrome (OSAS) is the most common condition among sleep-related respiratory disorders. The etiology is not clear. However, systemical and local inflammation in the respiratory tract of the patients has been acknowledged. Monocytes and macrophages play the critical role in the inflammation process. These cells participate in the release of the proinflammatory cytokines in inflammation sites. High-density lipoprotein (HDL) cholesterol is a molecule with an anti-inflammatory effect. Monocyte/HDL cholesterol ratio (MHR) is an inflammation marker being used recently. In our study, we aimed to compare inflammation marker levels between patients diagnosed with OSAS with subsequent polysomnography and the non OSAS group, determine the relationship between the severity of OSAS and MHR and, investigate the utility of the MHR for diagnosing OSAS. Materials and Methods: The data from the patients' files who had polysomnography due to OSAS symptoms in our unit between July 2017 and December 2017 have been retrospectively analyzed, and polysomnography results were recorded. Demographic data and the results of biochemistry and complete blood count (CBC) panels of patients with OSAS and who were not also were recorded. Results: Out of 147 patients who underwent polysomnography in the period identified, 104 were diagnosed with OSAS. Monocyte count and MHR values were significantly high (p<0,0001 in both) and HDL levels were significantly low (p=0,03) in OSAS group. There was also a moderately significant positive correlation between apnea-hypopnea index (AHI) and MHR (p<0,0001, r: 0,411). Conclusion: MHR may be a useful tool for diagnosing OSAS. Because of the positive correlation between MHR and AHI which represents the severity of the disease, MHR may be used for the classification of OSAS. Öz Amaç: Obstrüktif uyku apne sendromu (OSAS) uyku ile ilişkili solunum bozuklukları içerisinde en sık görülen hastalıktır. OSAS'ın etyolojisi kesin olarak bilinmemekle birlikte hastalarda sistemik ve havayolunda lokal inflamasyon varlığı gösterilmiştir. Monosit ve makrofajlar inflamasyonda rol alan önemli hücrelerdir. İnflamasyon bölgesinde proinflamatuar sitokinlerin salınmasında görev alırlar. Yüksek dansiteli lipoprotein (HDL) kolesterolü anti inflamatuar etkisi olan bir moleküldür. Monosit/HDL kolesterol oranı (MHO) yakın zamanda kullanılmaya başlanan bir inflamasyon belirtecidir. Çalışmamızda ünitemizde polisomnografi ile OSAS tanısı alanların ve almayanların Ad dress for Cor res pon den ce/Ya zış ma Ad re si:

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The ratio of monocyte frequency to HDL cholesterol level as a predictor of asymptomatic organ damage in patients with primary hypertension

Cited by 49 publications

References 26 publications

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome

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