2018
DOI: 10.5582/irdr.2017.01079
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The ratio of urinary α1-microglobulin to microalbumin can be used as a diagnostic criterion for tubuloproteinuria

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Cited by 10 publications
(5 citation statements)
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“…Recurrence-free periods ranged from 12 to 71 months Urinary β2 microglobulin level and HLA typing (especially HLA-DR4 or DRB1) may help in the diagnosis of TINU Zhang et al . (2018), People’s Republic of China [ 48 ] 4 Age 10.8–13.6 years All Pt presented with proteinuria and elevated urinary α-1-microglobulin. The ratio of urinary α1-microglobulin to microalbumin was greater than 1 NA NA All Pt seen within a 3-year period A ratio of urinary α1-microglobulin to microalbumin greater than 1 can be used as a diagnostic criterion for tubuloproteinuria Pereira et al .…”
Section: Discussionmentioning
confidence: 99%
“…Recurrence-free periods ranged from 12 to 71 months Urinary β2 microglobulin level and HLA typing (especially HLA-DR4 or DRB1) may help in the diagnosis of TINU Zhang et al . (2018), People’s Republic of China [ 48 ] 4 Age 10.8–13.6 years All Pt presented with proteinuria and elevated urinary α-1-microglobulin. The ratio of urinary α1-microglobulin to microalbumin was greater than 1 NA NA All Pt seen within a 3-year period A ratio of urinary α1-microglobulin to microalbumin greater than 1 can be used as a diagnostic criterion for tubuloproteinuria Pereira et al .…”
Section: Discussionmentioning
confidence: 99%
“…However, the intensity of a band visible in our electropherograms reflects mainly the concentrations of the most abundant proteins. The LC-MS/MS analysis confirmed the presence of several "indicator" proteins in the analyzed urine sample [18][19][20][21][22]. These include the proteins known to be present in pathological urine in high concentrations.…”
Section: Discussionmentioning
confidence: 65%
“…Nonetheless, an early and accurate recognition of the presence of proteinuria and the underlying cause is essential to provide appropriate patient care. In current clinical practice, the type of proteinuria may be assessed based on immunochemical measurements of selected "indicator" proteins: low molecular weight (LMW) proteins (i.e., with molecular mass lower than albumin) such as retinol-binding protein, β 2 -microglobulin, α 1microglobulin and cystatin C for tubular proteinuria; albumin and transferrin for glomerular proteinuria; and free light chains of immunoglobulin, myoglobin or lysozyme for overload proteinuria [18][19][20][21][22]. However, since immunochemical assays are relatively expensive, this diagnostic approach requires the initial diagnostic hypothesis: the initial misconception may substantially extend the entire diagnostic process.…”
Section: Introductionmentioning
confidence: 99%
“…Some nephrologists would prefer direct testing for LMW proteins such as α1-MG or β2-MG over urine protein electrophoresis, because these test are easier to perform and more widely available. A recent study carried out in Chinese pediatric patients with renal tubular and interstitial diseases suggested that the ratio of urinary α1-MG to albumin > 1 could be used as a diagnostic criterion for tubuloproteinuria [ 17 ]. Consistent with this report, urinary α1-MG to albumin in these three cases were all > 1, which might have some benefits for early diagnosis.…”
Section: Discussionmentioning
confidence: 99%