Tubulointerstitial nephritis and uveitis syndrome in an adolescent female: a case report

Petek, Tadej; Frelih, Maja; Varda, Nataša Marčun

doi:10.1186/s13256-021-03017-8

Cited by 3 publications

(10 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, mild anemia was found in two of the cases like ours [4,7]. Urinalysis showed proteinuria in three cases like our case [4,7,8], one of whom had hematuria without cellular casts [4]. Two cases revealed elevated α1-microglobulin and glucosuria [7,8].…”

Section: Table 1: Review Of Previously Published Case Reports and Art...supporting

confidence: 52%

“…Urinalysis showed proteinuria in three cases like our case [4,7,8], one of whom had hematuria without cellular casts [4]. Two cases revealed elevated α1-microglobulin and glucosuria [7,8]. Our patient's urinalysis showed proteinuria (50 mg/dL) and spot urine protein/creatinine ratio (0.75 g/g).…”

Section: Table 1: Review Of Previously Published Case Reports and Art...mentioning

confidence: 48%

“…One of the reported cases had a severely elevated creatinine level of 2,640 µmol/L with a urine volume of less than 300 mL/day which necessitated the initiation of acute hemodialysis [8]. In addition, mild anemia was found in two of the cases like ours [4,7]. Urinalysis showed proteinuria in three cases like our case [4,7,8], one of whom had hematuria without cellular casts [4].…”

Section: Table 1: Review Of Previously Published Case Reports and Art...mentioning

confidence: 62%

“…The age of diagnosis varied from 14 to 49 years of age. Three out of four patients were female [4,6,7]. The clinical presentation varied among the cases ranging from reduced visual acuity and/or burning sensation in the eyes with a blurred vision to lumbar pain, transitory dark urine, anorexia, weight loss, significant hypertension, progressive renal dysfunction, and periorbital and leg edema [4,[6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Certain precipitating factors for TINU are reported in three of the cases [6][7][8]: firstly, upper respiratory tract infection associated with mild conjunctivitis and found prior to the diagnosis of TINU [6]; secondly, the use of herbal medications in the preceding two weeks prior to a finding of elevated serum creatinine level and the diagnosis of TINU [8]; and thirdly, the presence of multiple chronic diseases including hypertension, dyslipidemia, obesity, and insulin resistance with a sedentary lifestyle [7]. Ophthalmic findings were present in all cases.…”

Section: Table 1: Review Of Previously Published Case Reports and Art...mentioning

confidence: 94%

See 4 more Smart Citations

A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report

Iqbal¹,

Alassafi²,

Alashaikh³

et al. 2022

Cureus

View full text Add to dashboard Cite

Tubulointerstitial nephritis with uveitis (TINU) is an uncommon autoimmune syndrome that involves multiple systems. It usually presents with acute kidney injury (AKI) and unilateral or bilateral uveitis. We present a 15-year-old male, fit and well, who attended emergency room (ER) with a four-month history of epigastric pain associated with nausea, vomiting, and weight loss of 10 kg. Initial clinical and laboratory evaluation confirmed AKI. A diagnostic kidney biopsy confirmed acute tubulointerstitial nephritis, and a slit-lamp examination confirmed acute left anterior uveitis consistent with a diagnosis of TINU. He was initially treated with corticosteroids which resulted in prompt resolution of AKI; however, uveitis persisted necessitating the addition of further immunosuppressants.

show abstract

Section: Table 1: Review Of Previously Published Case Reports and Art...supporting

confidence: 52%

Section: Table 1: Review Of Previously Published Case Reports and Art...mentioning

confidence: 48%

Section: Table 1: Review Of Previously Published Case Reports and Art...mentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Table 1: Review Of Previously Published Case Reports and Art...mentioning

confidence: 94%

See 3 more Smart Citations

A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report

Iqbal¹,

Alassafi²,

Alashaikh³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

TINU syndrome - literature review

SOWIŃSKI

Zdybel

KAMIŃSKA

et al. 2023

J Educ Health Sport

View full text Add to dashboard Cite

Introduction Tubulointerstitial nephritis with uveitis (TINU syndrome) is a rare condition which mainly affects young females. The pathomechanism of the TINU has not been still well understood but autoimmune background is suspected. Although it was first described in 1975, less than 600 cases have been reported so far. Aim of the study The aim of the study is to present the current knowledge about the TINU syndrome. Material and methods The article was created based on the PubMed database. Articles were searched in English using the following keywords: TINU syndrome, tubulointerstitial nephritis, uveitis. Results TINU syndrome occurs in 0.1-2% of patients with uveitis with no ethnic preferences. It has been linked to a number of potential causes including infectious, genetic, and jatrogenic factors. Clinical manifestation is often atypical what leads to underdiagnosis of disease. There are currently no established specific guidelines on the basis of which a diagnosis of TINU syndrome can be made. Therapy includes topical treatment and systemic corticosteroid therapy. The overall prognosis for patients is favorable, but it is possible to develop chronic kidney disease especially in adults. Summary: TINU syndrome remains a poorly understood disease and is often not taken into account in the diagnostic process. The lack of general treatment standards means that therapy is not always effective. Further research is needed to establish guidelines for the management of this disease.

show abstract

Rare Complication of Covid -19 Disease Tinu Syndrome in a 11-Year-Old Boy, Features and Managment

et al. 2022

View full text Add to dashboard Cite

Tubulointerstitial nephritis and uveitis syndrome (TINU) is a rare disease defined by a combination of different abnormalities, tubulointerstitial nephritis and uveitis. We describe an 11-year-old boy who got sick with the Covid-19 disease with positive outcome and after 2 weeks developed a complication – tubulointerstitial nephritis with pain in the abdominal cavity, loss of appetite, weakness and low-grade fever with further subsequent attachment of anterior uveitis. Laboratory indicators corresponded to renal insufficiency of tubular origin. Ophthalmological examination conducted against the background of redness of both eyes, photophobia, pain in the eyeball area and decreased vision confirmed bilateral uveitis. Analysis showed high levels of La/SS-B, anti-SARS-CoV-2 IgG with confirmed the suspicion of post-covid TINU syndrome. This case showed a good response to steroid therapy with long-term remission of nephritis and less clinical efficacy in the treatment of uveitis. Special attention should be paid to the occurrence of such a rare syndrome at an early stage after recovery from the Covid-19 disease.

show abstract

Tubulointerstitial nephritis and uveitis syndrome in an adolescent female: a case report

Cited by 3 publications

References 68 publications

A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report

A Young Man With Acute Kidney Injury and Uveitis: An Unusual Presentation and Case Report

TINU syndrome - literature review

Rare Complication of Covid -19 Disease Tinu Syndrome in a 11-Year-Old Boy, Features and Managment

Contact Info

Product

Resources

About