The Recently Introduced Rapidly-Acting Barbiturates; A Review and Critical Appraisal in Relation to Thiopentone

Barron, D. W.; Dundee, John W.

doi:10.1093/bja/33.2.81

Cited by 21 publications

(3 citation statements)

References 38 publications

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“…The doses used were: thiopentone 5 and 10 mg/kg, methohexitone 2 and 4 mg/kg, and propanidid 10 and 20 mg/kg. These dosage levels conform to the range generally held to be equipotent (Barron and Dundee, 1961;Howells et al, 1967;Thomas, 1967).…”

Section: Methodssupporting

confidence: 55%

A Comparison of the Acute Haemodynamic Effects of Thiopentone, Methohexitone and Propanidid in the Dog

Conway¹,

Ellis²,

King³

1968

British Journal of Anaesthesia

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The acute haemodynamic efifects of thiopentone, methohexitone and propanidid have been compared in anaesthetized dogs. All three drugs caused a reduction in arterial blood pressure and minor changes in cardiac output, but whereas thiopentone and methohexitone had similar effects propanidid was found to be three times as potent as thiopentone in its effect upon arterial systolic pressure. Thiopentone and methohexitone had slight effects upon right ventricular pressures, whilst propanidid markedly increased right ventricular systolic pressure.

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Section: Methodssupporting

confidence: 55%

A Comparison of the Acute Haemodynamic Effects of Thiopentone, Methohexitone and Propanidid in the Dog

Conway¹,

Ellis²,

King³

1968

British Journal of Anaesthesia

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“…We chose Alfaxalone because it is a neuroactive steroid used routinely in veterinary medicine as a safe and effective anaesthetic (Warne et al, 2015). Alfaxalone It is preferable to the drug that has been used more commonly in functional clearance assays, hexobarbital (e.g., Dearing et al, 2006;Kurnath and Dearing, 2013), because hexobarbital is a highly alkaline barbiturate drug (pH 11.5), and is thus an irritant when injected intraperitoneally, intramuscularly, or subcutaneously (Barron and Dundee, 1961). Animals were held in bags under observation until drowsy, and then removed and placed on their backs in an observation cage.…”

Section: Functional Clearance Assaysmentioning

confidence: 99%

Warmer Ambient Temperatures Depress Detoxification and Food Intake by Marsupial Folivores

Beale

Connors²,

Dearing³

et al. 2022

Front. Ecol. Evol.

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Ambient temperature is an underappreciated determinant of foraging behaviour in wild endotherms, and the requirement to thermoregulate likely influences food intake through multiple interacting mechanisms. We investigated relationships between ambient temperature and hepatic detoxification capacity in two herbivorous marsupials, the common ringtail possum (Pseudocheirus peregrinus) and common brushtail possum (Trichosurus vulpecula) that regularly feed on diets rich in plant toxins. As an indicator of hepatic detoxification capacity, we determined the functional clearance rate of an anaesthetic agent, Alfaxalone, after possums were acclimated to 10°C [below the thermoneutral zone (TNZ)], 18°C [approximately lower critical temperature (LCT)], and 26°C [approximately upper critical temperature (UCT)] for either 7 days or less than 24 h. We then measured intake of foods with high or low plant secondary metabolite (PSM) concentrations under the same temperature regimes. After 7 days of acclimation, we found a positive correlation between the functional clearance rate of Alfaxalone and ambient temperature, and a negative relationship between ambient temperature and intake of foods with high or low PSM concentrations for both species. The effect of ambient temperature on intake of diets rich in PSMs was absent or reduced when possums were kept at temperatures for less than 24 h. Our results underscore the effects of ambient temperature in hepatic metabolism particularly with respect intake of diets containing PSMs. Given that the planet is warming, it is vital that effects of ambient temperature on metabolism, nutrition and foraging by mammalian herbivores is taken into account to predict range changes of species and their impact on ecosystems.

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“…On reviewing the literature on methohexitone, Barron and Dundee (1961) found a lack of agreement concerning the incidence of complications associated with its use. This applied particularly to muscle twitchings and hiccough.…”

Section: Sodium 5-ethyl-5' (1-methyl Butyl) Thiobarbituratementioning

confidence: 99%

The Effects of Premedication With Phenothiazine Derivatives on the Course of Methohexitone Anaesthesia

Dundee

Moore

1961

British Journal of Anaesthesia

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The Recently Introduced Rapidly-Acting Barbiturates; A Review and Critical Appraisal in Relation to Thiopentone

Cited by 21 publications

References 38 publications

A Comparison of the Acute Haemodynamic Effects of Thiopentone, Methohexitone and Propanidid in the Dog

A Comparison of the Acute Haemodynamic Effects of Thiopentone, Methohexitone and Propanidid in the Dog

Warmer Ambient Temperatures Depress Detoxification and Food Intake by Marsupial Folivores

The Effects of Premedication With Phenothiazine Derivatives on the Course of Methohexitone Anaesthesia

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