The recurrence and survival of oral squamous cell carcinoma: a report of 275 cases

Abstract

Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck, and recurrence is an important prognostic factor in patients with OSCC. We explored the factors associated with recurrence of OSCC and analyzed the survival of patients after recurrence. Clinicopathologic and follow-up data of 275 patients with OSCC treated by surgery in the Cancer Institute and Hospital of Tianjin Medical University between 2002 and 2006 were analyzed. Recurrence factors were analyzed with Chi-square or Fisher's exact test and multivariate analysis. The prognosis of patients after recurrence was analyzed with the Kaplan-Meier method and log-rank test. The recurrence rate was 32.7%. The recurrence time ranged from 2 to 96 months, with a median of 14 months. Univariate analysis showed that T stage, degree of differentiation, pN stage, flap application, resection margin, and lymphovascular invasion were factors of recurrence (P < 0.05). Multivariate analysis showed that T stage, degree of differentiation, and pN stage were independent factors of recurrence (P < 0.001). The differences in gender, age, tumor site, region of lymph node metastasis, and perineural invasion between the recurrence and non-recurrence groups were not significant (P > 0.05). Kaplan-Meier and log-rank tests showed that the 2- and 5-year survival rates were significantly lower in the recurrence group than in non-recurrence group (67.6% vs. 88.0%, 31.8% vs. 79.9%, P < 0.001). Therefore, to improve prognosis, we recommend extended local excision, flap, radical neck dissection, and adjuvant chemoradiotherapy for patients more likely to undergo recurrence.

Role of Platelet Counts in Prognostication of Head And Neck Squamous Cell Carcinoma.

“…male to female ratio of head and neck squamous cell carcinoma is 1.9:1 with most commonly affected age group being 6 th decade. 17 Pre treatment thrombocytosis has proven to be an independent prognostic factor for poor outcome which was observed in our study. Recurrence of tumor was noted in 7cases.…”

“…18 Post-operative tumor recurrence leads to high morbidity & mortality. 17 High platelet count & poor tumor differentiation, presence of vascular invasion, regional & distant metastasis are poor prognostic factors in patient of head & neck squamous cell carcinoma.…”

Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression

“…5 The main challenge is that HPV infection is largely asymptomatic or causes only minor lesions. Discovery of HPVpositive oral HNSCC usually occurs at advanced stages, when extensive local invasions and metastasis could prevent complete surgical removal, leading to high recurrence rate and low 5-year survival rate.…”

Histopathological Differences Between Genders in Patients With Oral Squamous Cell Carcinoma

“…Interestingly, Chen et al also observed a higher prevalence of earlier stages among women, as well as an association between the presence of IL-6 tumor cytosolic, female gender and lymph node metastasis, demonstrating that other independent factors may also be involved in differences of metastasis risk between genders. It is possible that similar rates of lymph node metastasis may be correlated with similar disease survival curves when comparing men and women, since the N stage is one of the most important prognostic factors in oral cancer 12,13 .…”