2024
DOI: 10.1073/pnas.2400145121
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The red alga Porphyridium as a host for molecular farming: Efficient production of immunologically active hepatitis C virus glycoprotein

Alexander Hammel,
Lia-Maria Cucos,
Iuliana Caras
et al.

Abstract: Microalgae are promising production platforms for the cost-effective production of recombinant proteins. We have recently established that the red alga Porphyridium purpureum provides superior transgene expression properties, due to the episomal maintenance of transformation vectors as multicopy plasmids in the nucleus. Here, we have explored the potential of Porphyridium to synthesize complex pharmaceutical proteins to high levels. Testing expression constructs … Show more

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Cited by 4 publications
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