The red face: Lupus erythematosus

Jabłońska, Stefania; Blaszczyk‐Kostanecka, Maria; Chorzelski, Tadeusz P.; Jarzabek-Chorzelska, M

doi:10.1016/0738-081x(93)90061-g

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…LE edematosus appears as erythematous and edematous ill-defined plaques without characteristic scarring or follicular plugging, and often affects the face. 65 Since Jabloska described that these lesions can either resolve without leaving any residual changes or convert later into atrophic or classical DLE lesions, 65 we propose that some of these cases may indeed correspond to LET. Similarly, 'urticarial-plaque lupus erythematosus' may be best represented by what we call LET in the recent literature, as suggested by Lehmann.…”

Section: Clinical Manifestationsmentioning

confidence: 81%

Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates

Obermoser

Sontheimer

Zelger

2010

Lupus

162

158

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The skin is the second most frequently affected organ system in lupus erythematosus. Although only very rarely life threatening--an example is lupus erythematosus-associated toxic epidermal necrolysis--skin disease contributes disproportionally to disease burden in terms of personal and psychosocial wellbeing, vocational disability, and hence in medical and social costs. Since several manifestations are closely associated with the presence and activity of systemic lupus erythematosus, prompt and accurate diagnosis of cutaneous lupus erythematosus is essential. This review aims to cover common, rare, and atypical manifestations of lupus erythematosus-associated skin disease with a detailed discussion of histopathological correlates. Cutaneous lupus erythematosus covers a wide morphological spectrum well beyond acute, subacute and chronic cutaneous lupus erythematosus, which are commonly classified as lupus-specific skin disease. Other uncommon or less well-known manifestations include lupus erythematosus tumidus, lupus profundus, chilblain lupus, mucosal lupus erythematosus, and bullous lupus erythematosus. Vascular manifestations include leukocytoclastic and urticarial vasculitis, livedoid vasculopathy and livedo reticularis/ racemosa. Finally, we discuss rare presentations such as lupus erythematosus-related erythema exsudativum multiforme (Rowell syndrome), Kikuchi-Fujimoto disease, extravascular necrotizing palisaded granulomatous dermatitis (Winkelmann granuloma), and neutrophilic urticarial dermatosis.

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Section: Clinical Manifestationsmentioning

confidence: 81%

Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates

Obermoser

Sontheimer

Zelger

2010

Lupus

162

158

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“…The typical DLE may be found in 15 ± 25% of SLE patients during the course of their disease. 2,8,9 LE-nonspeci®c cutaneous manifestations are numerous, though without reliable diagnostic sig-ni®cance. Surprisingly, there has been very little information on the relationship between cutaneous lesions and disease activity in SLE.…”

Section: Introductionmentioning

confidence: 99%

Skin lesions - an indicator of disease activity in systemic lupus erythematosus?

Zecević

Vojvodić

Ristić³

et al. 2001

Lupus

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Cutaneous manifestations have great diagnostic value for systemic lupus erythematosus (SLE). In this study we tried to establish a correlation between lupus erythematosus LE-specific and LE-nonspecific cutaneous lesions and disease activity measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Sixty-six patients with SLE were evaluated. They were divided into three groups having: (1) only LE-specific lesions (38 or 58.46%); (2) only LE-nonspecific lesions (4 or 6.15%); and (3) both types of lesions (23 or 35.38%). Results were analyzed using the Student t-test. Patients with LE-nonspecific skin manifestations had significantly increased disease activity compared to those with only LE-specific lesions. The number of different skin lesion types also correlated with disease activity. It was significantly increased in a group with three different types of lesion, either specific or nonspecific. Patients with only one type of lesion had mild disease. An intermediate disease activity was found in the group with two different lesion types. Lupus-specific skin manifestations serve primarily as an important diagnostic clue. In conclusion, patients with LE-nonspecific lesions have significantly more active SLE than those with LE-specific lesions and may therefore require more intensive therapy and disease monitoring.

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“…Skin lesions are a common presentation in patients with SLE. As many as 70% of people with lupus have some skin symptoms, and approximately 25% of patients have cutaneous manifestations as a presenting sign [10, 11]. Skin involvement is second only to joint manifestations as the predominant manifestation of SLE, both at onset and later stages of the disease [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2

Feng

Peng

Zhou

et al. 2017

Cell Physiol Biochem

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Background/Aims: Basophils have been reported to infiltrate skin lesions in various skin diseases, but not in systemic lupus erythematosus (SLE). This study investigated basophil infiltration in SLE and its mechanism. Methods: Twenty newly diagnosed SLE patients and twenty healthy controls were enrolled. Nine SLE patients underwent skin biopsies. Flow cytometric analysis the phenotype of peripheral basophils and their migration rate toward RANTES and MCP-1 were analyzed with the transwell culture system, also the expression of these two chemokines in skin tissue were analyzed with immunohistochemistry. Results: Increased activation and decreased numbers of peripheral basophils were observed in SLE patients compared with controls. Basophil migration into skin lesions of SLE patients were observed, but not in normal skin tissue. This migration was related to the upregulation of chemokine receptors CCR1 and CCR2 on basophils. In vitro studies showed that migration rate toward RANTES and MCP-1 increased significantly in basophils from SLE patients compared with those from controls. Consistently, high levels of RANTES and MCP-1 expression were observed in skin lesions from SLE patients but not in normal skin tissue. Conclusion: Basophil recruitment to skin lesions of SLE patients mediated by CCR1 and CCR2, which may contribute to tissue damage in SLE.

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The red face: Lupus erythematosus

Cited by 7 publications

References 44 publications

Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates

Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates

Skin lesions - an indicator of disease activity in systemic lupus erythematosus?

Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2

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