The Reducing Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on High-Fat Diet-Induced Pyroptosis in Endothelial and Vascular Smooth Muscle Cells of Mice Aortas

Oh, Seyeon; Son, Myeongjoo; Park, Chul-Hyun; Jang, Ji Tae; Son, Kuk Hui; Byun, Kyunghee

doi:10.3390/md18120648

Cited by 20 publications

(13 citation statements)

References 47 publications

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“…PI staining results showed that BAY pretreatment also reduced the proportion of dead cells ( Zhaolin et al, 2019 ). Correspondingly, studies showed that melatonin and PPB alleviate atherosclerosis in HFD-fed ApoE −/− mice via inhibiting NF-κB-mediated pyroptosis in ECs( Schmitz and Ruebsaamen, 2010 ; Oh et al, 2020 ). It is well known that mitochondrial damage and reactive oxygen species (ROS) production are sufficient to activate NF-κB signal ( Morgan and Liu, 2011 ; Formentini et al, 2012 ).…”

Section: Pyroptosis In Atherosclerosismentioning

confidence: 99%

“…On the other hand, existing studies have indicated that multiple drugs and genes such as melatonin, salidroside (SAL), estrogen, pyrogallol-phloroglucinol-6,6-bieckol (PPB) and fibroblast growth factor 21 (FGF21) decrease atherosclerosis plaque formation via inhibiting ECs pyroptosis in vivo and in vitro ( Zhang et al, 2018 ; Oh et al, 2020 ; Xing et al, 2020 ; Zeng et al, 2020 ; Meng et al, 2021 ). Moreover, recent studis have discovered more drugs and miRNAs that could regulate ECs pyroptosis, including atorvastatin, miRNA-30c-5p, miRNA-125a-5p, etc.…”

Section: Pyroptosis In Atherosclerosismentioning

confidence: 99%

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Pyroptosis in the Initiation and Progression of Atherosclerosis

Qian

Zhao²,

Wan³

et al. 2021

Front. Pharmacol.

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Pyroptosis, a newly discovered form of programmed cell death, is characterized by cell swelling, the protrusion of large bubbles from the plasma membrane and cell lysis. This death pathway is mediated by the pore formation of gasdermin D (GSDMD), which is activated by human caspase-1/caspase-4/caspase-5 (or mouse caspase-1/caspase11), and followed with the releasing of both cell contents and proinflammatory cytokines. Pyroptosis was initially found to function as an innate immune effector mechanism to facilitate host defense against pathogenic microorganisms, and subsequent studies revealed that pyroptosis also plays an eventful role in inflammatory immune diseases and tumor resistance. Recent studies have also shown that pyroptosis is involved in the initiation, the progression and complications of atherosclerosis. Here, we provide an overview of the role of pyroptosis in atherosclerosis by focusing on three important participating cells: ECs, macrophages, and SMCs. In addition, we also summarized drugs and stimuli that regulate the progression of atherosclerosis by influencing cell pyroptosis.

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Section: Pyroptosis In Atherosclerosismentioning

confidence: 99%

Section: Pyroptosis In Atherosclerosismentioning

confidence: 99%

Pyroptosis in the Initiation and Progression of Atherosclerosis

Qian

Zhao²,

Wan³

et al. 2021

Front. Pharmacol.

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“…Xianxian Wu et al ( Wu et al, 2018 ) proved that nicotine induces atherosclerosis by stimulating the production of ROS to activate the classic pyroptosis pathway of caspase-1-dependent endothelial cells. In addition to nicotine, hyperlipidaemia, proinflammatory factors and many other factors are all induced by activating the caspase-1-sirtuin1-activator protein-1 pathway ( Yin et al, 2015 ; Oh et al, 2020 ). This also suggests that we can treat certain cardiovascular diseases by preventing the activation of caspase-1.…”

Section: Mitochondrial and Systemic Diseasesmentioning

confidence: 99%

Mitochondria Related Cell Death Modalities and Disease

Tian

Liu

et al. 2022

Front. Cell Dev. Biol.

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Mitochondria are well known as the centre of energy metabolism in eukaryotic cells. However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative phosphorylation but also control the mode of cell death through various mechanisms, especially regulated cell death (RCD), such as apoptosis, mitophagy, NETosis, pyroptosis, necroptosis, entosis, parthanatos, ferroptosis, alkaliptosis, autosis, clockophagy and oxeiptosis. These mitochondria-associated modes of cell death can lead to a variety of diseases. During cell growth, these modes of cell death are programmed, meaning that they can be induced or predicted. Mitochondria-based treatments have been shown to be effective in many trials. Therefore, mitochondria have great potential for the treatment of many diseases. In this review, we discuss how mitochondria are involved in modes of cell death, as well as basic research and the latest clinical progress in related fields. We also detail a variety of organ system diseases related to mitochondria, including nervous system diseases, cardiovascular diseases, digestive system diseases, respiratory diseases, endocrine diseases, urinary system diseases and cancer. We highlight the role that mitochondria play in these diseases and suggest possible therapeutic directions as well as pressing issues that need to be addressed today. Because of the key role of mitochondria in cell death, a comprehensive understanding of mitochondria can help provide more effective strategies for clinical treatment.

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“…Oh et al found that Pyrogallol-Phloroglucinol-6,6-Bieckol (PPB) significantly hindered monocyte migration and macrophage differentiation towards the inflammatory phenotype ( Oh et al, 2018 ). Thus, PPB reduces monocyte-induced EC death and monocyte-induced VSMC proliferation and migration, and the effect of PPB on pyroptosis (leading to attenuation of these cells and aortic cell dysfunction) of endothelial cells and VSMCs in high-fat diet (HFD)-fed mice ( Oh et al, 2020 ). In a high glyceride, high cholesterol environment, SIRT1 expression is suppressed, leading to reduced reverse cholesterol transport, mediating the differentiation of monocytes to foam cells and impeding the reduction of foam cells in atherosclerotic plaques ( Kitada et al, 2016 ).…”

Section: The Molecular Pathways Of Pyroptosis In Atherosclerosismentioning

confidence: 99%

The Molecular Pathways of Pyroptosis in Atherosclerosis

Song

et al. 2022

Front. Cell Dev. Biol.

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Atherosclerosis (AS) is a chronic inflammatory disease seriously endangering human health, whose occurrence and development is related to many factors. Pyroptosis is a recently identified novel programmed cell death associated with an inflammatory response and involved in the formation and progression of AS by activating different signaling pathways. Protein modifications of the sirtuin family and microRNAs (miRNAs) can directly or indirectly affect pyroptosis-related molecules. It is important to link atherosclerosis, thermogenesis and molecular modifications. This article will systematically review the molecular pathways of pyroptosis in AS, which can provide a new perspective for AS prevention and treatment.

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The Reducing Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on High-Fat Diet-Induced Pyroptosis in Endothelial and Vascular Smooth Muscle Cells of Mice Aortas

Cited by 20 publications

References 47 publications

Pyroptosis in the Initiation and Progression of Atherosclerosis

Pyroptosis in the Initiation and Progression of Atherosclerosis

Mitochondria Related Cell Death Modalities and Disease

The Molecular Pathways of Pyroptosis in Atherosclerosis

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