The reduction in inflammation and impairment in wound healing by using strontium chloride hexahydrate

Hayta, Sibel Berksoy; Durmuş, Kasım; Altuntaş, Emine Elif; Yıldız, Esin; Hisarciklıo, Mehmet; Akyol, Melih

doi:10.1080/15569527.2017.1326497

Cited by 35 publications

(21 citation statements)

References 27 publications

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“…One of the mainstream regulators of PBM-induced cascades is the Transforming Growth Factor-β1, which is directly activated from its latent state by light 2,3 . Besides many other functions, Transforming Growth Factor-β induces chemotaxis of inflammatory and immune cells to the wound site, drives stem cell differentiation, and mediates collagen type III replacement with collagen type I 49 . Recently, the study of Parfejevs et al showed that injury-activated glia cells promote myofibroblast differentiation by paracrine modulation of Transforming Growth Factor-β signalling in wound healing 50 .…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation drives pericyte mobilization towards skin regeneration

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et al. 2020

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Photobiomodulation is being widely applied for improving dermal or mucosal wound healing. However, the underlying cellular and molecular processes that directly contribute to its effects remain poorly understood. Pericytes are relevant cells involved in the wound microenvironment and could be one of the main targets of photobiomodulation due to their plasticity and perivascular localization. Herein, we investigate tissue repair under the photobiomodulation stimulus using a pericyte labeled (or reporter) transgenic mice. Using a model of two contralateral back wounds, one the control and the other photoactivated daily (660 nm, 20 mW, 0.71 W/cm2, 5 J/cm2, 7 s, 0.14 J), we showed an overall influx of immune and undifferentiated cells and higher mobilization of a potent pericyte subpopulation (Type-2 pericytes) in the photoactivated wounds in comparison to the controls. Doppler analysis showed a significant increase in the blood flow in the photoactivated wounds, while marked vascular supply was observed histologically. Histochemical analysis has indicated more advanced stages of tissue repair after photoactivation. These data suggest that photobiomodulation significantly accelerates tissue repair through its vascular effects with direct recruitment of pericytes to the injury site.

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Section: Discussionmentioning

confidence: 99%

Photobiomodulation drives pericyte mobilization towards skin regeneration

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et al. 2020

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“…Chronic wound healing can be improved by the application of strontium compounds through its anti‐inflammatory activity (Berksoy Hayta et al . 2018). Si‐based nanoparticles are believed to favour fibrous tissue formation by stimulating fibroblast proliferation and migration at wound sites (Quignard et al .…”

Section: Discussionmentioning

confidence: 99%

The potential of a surface pre‐reacted glass root canal dressing for treating apical periodontitis in rats

et al. 2020

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AimTo evaluate the efficacy of a prototype root canal dressing containing surface pre‐reacted glass–ionomer (S‐PRG) fillers on repairing induced periapical lesions in a rat model. Calcium hydroxide [Ca(OH)2] was applied as a comparison in the healing process.MethodologyThe pulp chambers of the maxillary first molars in 64 male Wistar rats aged 16 weeks were opened to induce periapical lesions. After 28 days, the mesial canal of each tooth was prepared, irrigated with 2.5% sodium hypochlorite only (control group: irrigation) or followed by the respective dressing [Ca(OH)2 group, irrigation + Ca(OH)2; S‐PRG group, irrigation + S‐PRG] and restored with composite resin for 3 or 7 days (10/group). Four rats with healthy molars were used as blank controls. Descriptive analysis of the periapical radiographs, haematoxylin and eosin staining and immunohistochemical observation was performed 3 and 7 days after treatment. The periapical grey value, CD68 macrophages and osteoclasts (cathepsin‐K) were quantified and statistically analysed with Tukey’s honest significant difference test. A significant difference was achieved when P values were <0.05.ResultsS‐PRG and Ca(OH)2 dressings were associated with increased periapical grey values and inhibited osteoclast activity at 3 and 7 days; a significant difference in radiographic results and the number of osteoclasts was obtained at 3 and 7 days compared with the control group (P < 0.05). Reparative tissue was observed histologically in the space of the periapical resorbed necrotic area after S‐PRG and Ca(OH)2 treatment for 3 and 7 days. The number of macrophages was significantly decreased at 3 and 7 days in the S‐PRG and Ca(OH)2 specimens when compared with the controls (P < 0.05).ConclusionsIn a rat experimental model, the S‐PRG root canal dressing was comparable to Ca(OH)2 in promoting the healing of experimentally induced periapical lesions. S‐PRG paste has the potential to be used as an alternative intracanal dressing in teeth with apical periodontitis.

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“…Wound healing effects of strontium chloride hexahydrate has been evaluated in vivo. This strontium salt was shown to reduce TNF-α expression in the wound site and, therefore, reduce inflammation [ 84 ], which is of special use in chronic inflammatory disorders. The antioxidant effect is also related to Sr, according to previous studies [ 85 ] that used strontium-substituted bioglass for tissue engineering purposes.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels

et al. 2020

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Inorganic hydrogels formulated with spring waters and clay minerals are used to treat musculoskeletal disorders and skin affections. Their underlying mechanism of action for skin disorders is not clear, although it is usually ascribed to the chemical composition of the formulation. The aim of this study was to assess the composition and in vitro release of elements with potential wound healing effects from hydrogels prepared with two nanoclays and natural spring water. In vitro Franz cell studies were used and the element concentration was measured by inductively coupled plasma techniques. Biocompatibility studies were used to evaluate the potential toxicity of the formulation against fibroblasts. The studied hydrogels released elements with known therapeutic interest in wound healing. The released ratios of some elements, such as Mg:Ca or Zn:Ca, played a significant role in the final therapeutic activity of the formulation. In particular, the proliferative activity of fibroblasts was ascribed to the release of Mn and the Zn:Ca ratio. Moreover, the importance of formulative studies is highlighted, since it is the optimal combination of the correct ingredients that makes a formulation effective.

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The reduction in inflammation and impairment in wound healing by using strontium chloride hexahydrate

Abstract: Strontium chloride hexahydrate can lead to impairment in wound healing by suppressing inflammation through TNF-alpha.

Cited by 35 publications

References 27 publications

Photobiomodulation drives pericyte mobilization towards skin regeneration

Photobiomodulation drives pericyte mobilization towards skin regeneration

The potential of a surface pre‐reacted glass root canal dressing for treating apical periodontitis in rats

Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels

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