The Regulation of the Mammalian Corpus Luteum

Rothchild, I.

doi:10.1016/b978-0-12-571137-1.50009-8

Cited by 268 publications

(208 citation statements)

References 499 publications

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“…Mattioli et al (1985) (Davis et al, 1987(Davis et al, , 1989. Prostaglandin F2a inhibits luteal steroidogenesis in vitro when lipoproteins are present in the culture medium (Pate & Nephew, 1988;Wiltbank et al, 1990) and incu¬ bation times were longer than 4-6 h (Fritz et ai, 1991 (Bazer et al, 1982) by prostaglandins of luteal origin, as suggested by Rothchild (1981). Guthrie & Rexroad (1981) demonstrated that the peak of PGF2a secretion during the late luteal phase in nonpregnant pigs usually occurs after the initial decrease in plasma progesterone.…”

Section: Discussionmentioning

confidence: 75%

Effect of prostaglandins on luteal function during early pregnancy in pigs

Więsak

Hunter²,

Foxcroft³

1992

Reproduction

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Summary. Luteal cells were obtained by digestion of luteal tissue of cyclic (day 12) and early pregnant (days 12, 20 and 30) pigs. Suspensions of the dispersed luteal cells (5 x 104 cells ml \m=-\1) were incubated for 2 h in minimum essential medium (MEM) alone (control) and MEM with different concentrations of prostaglandin FF2\ g=a\(PGF2\g=a\) and PGE2 (0\m=.\01,0\m=.\1,1, 10, 100 and 1000 ng ml \m=-\1) and luteinizing hormone (LH) 100 and 1000 ng ml\m=-\1, or with combinations of LH+ PGF2\g=a\and LH + PGE2. Net progesterone production was measured in the incubation media by direct radioimmunoassay.The overall response pattern of the luteal cells to exogenous hormones on day 12 of the oestrous cycle and pregnancy differed (P < 0\m=.\5) from treatment on day 20 and 30 of pregnancy. In general progesterone production was higher (P < 0\m=.\5) and the response to PGF2\g=a\ and PGE2 treatment was most obvious on day 12 of the oestrous cycle and pregnancy. Overall, PGF2\g=a\ stimulated progesterone production in a dosedependent manner (P < 0\m=.\05). The response to PGE2 was of a quadratic nature (P < 0\m=.\05) in which the lowest and the highest doses of PGE2 were associated with a greater production of progesterone than were the intermediate doses. Treatment of luteal cells with PGF2\g=a\ + LH or PGE2 + LH caused overall inhibition (P < 0\m=.\05) of progesterone production compared with treatment with each hormone alone. This interaction was not affected by the dose of LH used.These findings indicate that PGF2\g=a\ and PGE2 are involved in the autocrine control of corpus luteum function.

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Section: Discussionmentioning

confidence: 75%

Effect of prostaglandins on luteal function during early pregnancy in pigs

Więsak

Hunter²,

Foxcroft³

1992

Reproduction

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“…However, it is well established that ß-adrenergic receptors in the corpus luteum are functionally coupled to adenylate cyclase and progesterone synthesis (Spicer, 1986). It is also known that newly formed rat corpora (Rothchild, 1981). Prolactin is known to convert the corpus luteum of the oestrous cycle into one of pseudopregnancy or pregnancy by promoting the development of LH receptors (Richards & Williams, 1976).…”

Section: Discussionmentioning

confidence: 99%

-Adrenergic receptor concentration and subtype in the corpus luteum of the adult pseudopregnant rat

Norjavaara

Rosberg²,

Gåfvels³

et al. 1989

Reproduction

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Summary. Luteal \g=b\-adrenergicreceptor concentration and subtype were determined in adult pseudopregnant rats during and after the period of the functional luteal phase.was used to determine the receptor concentration in corpora lutea of adult pseudopregnant rats. A 3-fold increase in \g=b\-adrenergicreceptor concentration was seen during the first 2\p=n-\3 days of pseudopregnancy, whereafter the receptor concentration declined. During the functional luteal regression period (Day 12\p=n-\15) the receptor levels were still low. In regressed (Day 16\p=n-\22)corpora lutea a temporary increase in \g=b\-receptor concentration was seen which may represent some role for \g=b\-adrenergic mechanisms in the regulation of morphological regression in the corpus luteum.To determine the \g=b\-adrenergicsubtype, competition of [125I]ICYP-binding with selective \ g=b\ 1 and \g=b\2-adrenergic antagonists was assessed in corpora lutea of different ages and in rat heart and uterus. The \g=b\-adrenergicreceptors in corpora lutea of adult pseudopregnant rats were shown to be solely of the subtype \ g=b\ 2, regardless of the luteal age.

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“…The serection of estrogen is eventually restrained, but the physiological estrogen level is stimulative for lactation maintenance. The Mongolian gerbil displays a postpartum ovulation phenomenon [18], and the suckling stimulus during early lactation allows the corpus luteum that is formed after ovulation to become functional and secrete progesterone [7,10,25,31]. Prolactin (PRL) induced by the suckling stimulus maintains the corpus luteum function and induces continuous P4 secretion [28,34].…”

Section: Hormonal Variations During Lactation In Primiparous Mongoliamentioning

confidence: 99%

Variations of Serum Estradiol and Progesterone Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

Shi

2010

Exp. Anim.

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Serum estradiol (E2) and progesterone (P4) levels were measured by chemiluminescence immunoassay (CLIA) during consecutive reproductive states in Mongolian gerbils. The results show that E2 and P4 levels throughout the estrous cycle in Mongolian gerbils peaked at proestrus and estrus, respectively. During gestation in primiparous and multiparous gerbils, E2 levels reached a small peak on day 6 and a maximum peak on day 21, followed by a slight decline until parturition. Thereafter, they dropped sharply during the first 3 days of lactation and remained stable until lactation ended. P4 levels reached a peak on day 12 during gestation in primiparous gerbils, while they peaked on day 6 in multiparous gerbils. The levels of P4 then decreased until parturition. During lactation, P4 levels peaked on day 9 in primiparous gerbils, while they peaked on day 6 in multiparous gerbils, and then the levels declined gradually until lactation ended. The findings suggest that the variations of E2 levels during the estrous cycle, gestation and lactation in Mongolian gerbils are similar to those observed in rats and mice. Changes in E2 levels during different reproductive states were the same in the primiparous and multiparous gerbils, but the variations in P4 levels did not display this tendency. Changing patterns of E2 and P4 levels are suitable for the reproductive stages of Mongolian gerbils.

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The Regulation of the Mammalian Corpus Luteum

Cited by 268 publications

References 499 publications

Effect of prostaglandins on luteal function during early pregnancy in pigs

Effect of prostaglandins on luteal function during early pregnancy in pigs

-Adrenergic receptor concentration and subtype in the corpus luteum of the adult pseudopregnant rat

Variations of Serum Estradiol and Progesterone Levels during Consecutive Reproductive States in Mongolian Gerbils (Meriones unguiculatus)

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