The regulatory role of curcumin on platelet functions

Tabeshpour, Jamshid; Hashemzaei, Mahmoud; Sahebkar, Amirhossein

doi:10.1002/jcb.27192

Cited by 33 publications

(23 citation statements)

References 78 publications

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“…However, approved drugs for the treatment of cancer are usually limited by potential undesirable side effects such as hepatotoxicity, nephrotoxicity, ototoxicity, reduction in platelet counts, and myelosuppression . Curcumin, a natural polyphenolic compound and the principal coloring agent found in the rhizomes of Curcuma longa (Zingiberaceae), has several health benefits, including antioxidant , anti‐inflammatory , immunomodulatory , antiarthritic , antithrombotic , pulmonoprotective , lipid‐modifying , neuroprotective , anticancer , antidiabetic, and hepatoprotective properties. Numerous reports have indicated that curcumin is quite safe and nontoxic to humans up to doses of 12 g/day .…”

Section: Introductionmentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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Section: Introductionmentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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“…Furthermore, curcumin supplementation causes increased bile formation and demonstrates cholekinetic effects [57,58]. Moreover, curcumin presents antiplatelet, anticoagulation, and fibrinolysis activities [59,60]. In addition, curcumin supplementation increases insulin sensitivity and subsequently leads to lower blood glucose levels among diabetic patients who were taking diabetes medications [61,62].…”

Section: Common Adverse Effects Between Covid-19 and Curcuminmentioning

confidence: 99%

Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19

Heidari

Mohammadi

Sahebkar

2021

Advances in Experimental Medicine and Biology

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The novel coronavirus outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was recognized in late 2019 in Wuhan, China. Subsequently, the World Health Organization declared coronavirus disease 2019 (COVID-19) as a pandemic on 11 March 2020. The proportion of potentially fatal coronavirus infections may vary by location, age, and underlying risk factors. However, acute respiratory distress syndrome (ARDS) is the most frequent complication and leading cause of death in critically ill patients. Immunomodulatory and anti-inflammatory agents have received great attention as therapeutic strategies against COVID-19. Here, we review potential mechanisms and special clinical considerations of supplementation with curcumin as an anti-inflammatory and antioxidant compound in the setting of COVID-19 clinical research.

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“…Curcumin is a naturally occurring nutraceutical compound with diverse pharmacological impacts such as antioxidant, anti-inflammatory, anti-diabetic and anti-tumor [118,119,120,121]. It appears that curcumin is capable of targeting different signaling pathways in stimulation of its anti-tumor activity and JAK-STAT pathway is one of them [122,123,124,125].…”

Section: Stats Inhibitorsmentioning

confidence: 99%

Nanoparticles Targeting STATs in Cancer Therapy

Ashrafizadeh

Ahmadi

Kotla

et al. 2019

Cells

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Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metastasis. It has been shown that signal transducers and activator of transcription (STAT) contributes to the progression of cancer cells. This important signaling pathway is associated with a number of biological processes including cell cycle, differentiation, proliferation and apoptosis. It appears that dysregulation of the STAT signaling pathway promotes the migration, viability and malignancy of various tumor cells. Hence, there have been many attempts to target the STAT signaling pathway. However, it seems that currently applied therapeutics may not be able to effectively modulate the STAT signaling pathway and suffer from a variety of drawbacks such as low bioavailability and lack of specific tumor targeting. In the present review, we demonstrate how nanocarriers can be successfully applied for encapsulation of STAT modulators in cancer therapy.

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The regulatory role of curcumin on platelet functions

Cited by 33 publications

References 78 publications

Biological properties of metal complexes of curcumin

Biological properties of metal complexes of curcumin

Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19

Nanoparticles Targeting STATs in Cancer Therapy

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