The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty

Reid, David; Toole, Barry; Knox, Susan; Talwar, Dinesh; Harten, J.; O’Reilly, Denis St. J.; Blackwell, Scott; Kinsella, John; McMillan, Donald C.; Wallace, A. M.

doi:10.3945/ajcn.110.008490

Cited by 268 publications

(241 citation statements)

References 30 publications

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“…This phenomenon seems to be remarkably stronger in older than younger individuals (Börgermann et al 2012). However, 25(OH)D concentrations remain low 3 months after surgery (Reid et al 2011) despite the normalization of CRP status, suggesting that factors other than inflammation may be responsible for the postsurgical decline in vitamin D.…”

Section: Discussionmentioning

confidence: 98%

Relationship between vitamin D and inflammatory markers in older individuals

Vita

Lauretani

Bauer

et al. 2014

AGE

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In older persons, vitamin D insufficiency and a subclinical chronic inflammatory status frequently coexist. Vitamin D has immune-modulatory and in vitro anti-inflammatory properties. However, there is inconclusive evidence about the anti-inflammatory role of vitamin D in older subjects. Thus, we investigated the hypothesis of an inverse relationship between 25-hydroxyvitamin D (25(OH)D) and inflammatory markers in a population-based study of older individuals. After excluding participants with high-sensitivity C-reactive protein (hsCRP)≥10 mg/dl and those who were on chronic anti-inflammatory treatment, we evaluated 867 older adults ≥65 years from the InCHIANTI Study. Participants had complete data on serum concentrations of 25(OH)D, hsCRP, tumor necrosis factor (TNF)-α, soluble TNF-α receptors 1 and 2, interleukin (IL)-1β, IL-1 receptor antagonist, IL-10, IL-18, IL-6, and soluble IL-6 receptors (sIL6r and sgp130). Two general linear models were fit (model 1-adjusted for age, sex, and parathyroid hormone (PTH); model 2-including covariates of model 1 plus dietary and smoking habits, physical activity, ADL disability, season, osteoporosis, depressive status, and comorbidities). The mean age was 75.1±17.1 years±SD. In model 1, AGE (2014) log(25OH-D) was significantly and inversely associated with log(IL-6) (β±SE=−0.11±0.03, p=<0.0001) and log (hsCRP) (β±SE=−0.04±0.02, p=0.04) and positively associated with log(sIL6r) (β±SE=0.11±0.04, p=0.003) but not with other inflammatory markers. In model 2, log (25OH-D) remained negatively associated with log (IL-6) (β±SE=−0.10±0.03, p=0.0001) and positively associated with log(sIL6r) (β±SE=0.11± 0.03, p = 0.004) but not with log(hsCRP) (β ±SE= −0.01±0.03, p=0.07). 25(OH)D is independently and inversely associated with IL-6 and positively with sIL6r, suggesting a potential anti-inflammatory role for vitamin D in older individuals.

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Section: Discussionmentioning

confidence: 98%

Relationship between vitamin D and inflammatory markers in older individuals

Vita

Lauretani

Bauer

et al. 2014

AGE

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“…This period of follow-up and resolution of inflammation matches our study and represents six elimination half-lives of 25(OH)D which is long enough for a new 25(OH)D equilibrium. Reid et al 7 excluded the possibility that the fall in 25(OH)D was due to inflammation, fall in vitamin D binding protein and iatrogenic dilution.…”

Section: Discussionmentioning

confidence: 99%

Serum 25 hydroxy-vitamin D does not exhibit an acute phase reaction after acute myocardial infarction

et al. 2012

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Background: There is growing epidemiological evidence linking serum 25 hydroxy-vitamin D (25(OH)D) concentrations to outcome in cardiovascular and other diseases. We have studied patients with acute myocardial infarction (AMI) to determine if they exhibit an acute phase reaction affecting 25(OH)D. Methods: Patients (n ¼ 32) with first AMI who had been treated with primary percutaneous coronary intervention within 12 h of symptom onset had venous blood samples taken two days, one week, one month and three months after presentation. Samples were analysed for troponin I, C-reactive protein (CRP) and 25(OH)D. Results: All patients had significant rises in troponin confirming the myocardial damage and CRP, both of which resolved by 28 days. In contrast, 25(OH)D remained unchanged throughout the 90-day observation period with a median concentration of 46 nmol/L. Conclusion: Serum 25(OH)D does not change after AMI and is likely to be a reliable marker of vitamin D status in patients with cardiovascular disease.

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“…There are multiple potential explanations, including differential compliance, malabsorption, increased losses (eg, capillary leak), and altered hepatic or end-organ metabolism. [118][119][120][121][122] Together, these findings suggest that rapid normalization of vitamin D status may require consideration of age (or weight), baseline 25(OH)D level, and disease status. Prediction of 25(OH)D levels by using the multivariate model suggested that 50 000 IU is appropriate in young infants, whereas doses in the 300 000 to 600 000 IU range may be required in adolescents.…”

Section: Adverse Event Analysismentioning

confidence: 95%

Rapid Normalization of Vitamin D Levels: A Meta-Analysis

et al. 2015

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BACKGROUND: Vitamin D deficiency may represent a modifiable risk factor to improve outcome in severe illness. The efficacy of high-dose regimens in rapid normalization of vitamin D levels is uncertain. METHODS:We conducted a systematic review of pediatric clinical trials administering high-dose vitamin D to evaluate 25-hydroxyvitamin D (25[OH]D) response and characteristics associated with final 25(OH)D levels by using Medline, Embase, and the Cochrane Central Register of Controlled Trials, including reference lists of systematic reviews and eligible publications. Uncontrolled and controlled trials reporting 25(OH)D levels after high-dose ($1000 IU) ergocalciferol or cholecalciferol were selected. Two reviewers independently extracted and verified predefined data fields. RESULTS:We identified 88 eligible full-text articles. Two of 6 studies that administered daily doses approximating the Institute of Medicine's Tolerable Upper Intake Level (1000-4000 IU) to vitamin D-deficient populations achieved group 25(OH)D levels .75 nmol/L within 1 month. Nine of 10 studies evaluating loading therapy (.50 000 IU) achieved group 25(OH)D levels .75 nmol/L. In meta-regression, baseline 25(OH)D, regimen type, dose, age, and time factors were associated with final 25(OH)D levels. Adverse event analysis identified increased hypercalcemia risk with doses .400 000 IU, but no increased hypercalcemia or hypercalciuria with loading doses ,400 000 IU (or 10 000 IU/kg). Few studies in adolescents evaluated loading dose regimens .300 000 IU.CONCLUSIONS: Rapid normalization of vitamin D levels is best achieved by using loading therapy that considers disease status, baseline 25(OH)D, and age (or weight). Loading doses .300 000 IU should be avoided until trials are conducted to better evaluate risk and benefit. Dr McNally conceptualized and designed the study, carried out the initial analysis, drafted the initial manuscript, and revised the manuscript for important intellectual content; Mr Iliriani, Dr Pojsupap, and Ms O'Hearn designed the data collection instrument, determined study eligibility, acquired data, and revised the article critically for important intellectual content; Dr Sampson conceptualized and designed the search strategy, acquired data, drafted the initial manuscript, and revised the manuscript for important intellectual content; Drs McIntyre, Fergusson, and Menon conceptualized and designed the study, interpreted the data, and critically revised the manuscript for important intellectual content; and all authors approved the final manuscript as submitted.The systematic review was registered with PROSPERO (identifier CRD42013006677). Normalization of vitamin D status has the potential to speed recovery and improve outcomes in multiple acutely unwell pediatric populations. Most of the guidelines and clinical practice surrounding vitamin D dosing involves a daily intake of ,1000 IU. 6,7 Because these standard dosing strategies target healthy children and require months to restore normal levels, they are not applicab...

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The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty

Abstract: Plasma concentrations of 25(OH)D decrease after an inflammatory insult and therefore are unlikely to be a reliable measure of 25(OH)D status in subjects with evidence of a significant systemic inflammatory response.

Cited by 268 publications

References 30 publications

Relationship between vitamin D and inflammatory markers in older individuals

Relationship between vitamin D and inflammatory markers in older individuals

Serum 25 hydroxy-vitamin D does not exhibit an acute phase reaction after acute myocardial infarction

Rapid Normalization of Vitamin D Levels: A Meta-Analysis

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