The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee

Osch, Gerjo J. V. M. van; Kraan, P.M. van der; Valburg, A. A. Van; Berg, Wim B. van den

doi:10.1007/bf01409983

Cited by 38 publications

(25 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 In a murine model of OA a good correlation has been reported between osteophyte size and cartilage damage. 6 In our study a similarly strong association was observed between osteophyte size and local cartilage narrowing, especially in the medial TFJ and lateral PFJ. However, osteophyte size in the lateral TFJ showed a stronger association with narrowing in the medial TFJ and lateral PFJ than in its own compartment, and osteophyte size in the medial PFJ showed no correlation with local narrowing but an association with narrowing in the medial TFJ.…”

Section: Discussionsupporting

confidence: 78%

“…van Osch et al speculated that cartilage damage and osteophyte formation are not directly linked but that both are induced by the same factor and develop independently of each other. 6 Such independent development may have been observed in the lateral PFJ and medial TFJ, where osteophyte size associates more with lateral patella subluxation and femorotibial angle, respectively, than with local narrowing.…”

Section: Discussionmentioning

confidence: 95%

“…1 3 Although osteophyte is viewed as a remodelling and reparative feature of OA, the factors that determine osteophyte formation and growth are unknown. Growth factors influence both chondrocyte synthesis and osteophyte formation in experimental joint damage, 4 5 and evidence from animal 6 and human studies [7][8][9] shows that cartilage damage initiates "secondary" osteophyte growth. However, osteophyte may also develop as an isolated feature associated with age 10 and precede rather than follow cartilage loss in animal studies.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study

Nagaosa

2002

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

Objectives: To examine the size and direction of osteophyte in knee osteoarthritis (OA) and to determine associations between osteophyte size and other radiographic features. Methods: Knee radiographs (standing extended anteroposterior and 30 degrees flexion skyline views) were examined from 204 patients referred to hospital with symptomatic knee OA (155 women, 49 men; mean age 70, range 34-91 years). A single observer assessed films for osteophyte size and direction at eight sites; narrowing in each compartment; varus/valgus angulation; patellofemoral subluxation; attrition; and chondrocalcinosis using a standard atlas, direct measurement, or visual assessment. For analysis, one OA knee was selected at random from each subject. Results: Osteophyte direction at the eight sites was divisible into five categories. At all sites, except for the lateral tibial plateau and the medial patella, osteophyte direction varied according to (a) the size of osteophyte and (b) the degree of local narrowing. At the medial femur, medial tibia, and lateral femur osteophyte direction changed from being predominantly horizontal to predominantly vertical with increasing size. The size of osteophyte correlated positively with the severity of local narrowing, except for the medial patellofemoral compartment where osteophyte size correlated positively with the severity of narrowing in the medial tibiofemoral compartment. Logistic regression analysis showed that osteophyte size was associated not only with local narrowing but also with local malalignment and bone attrition, and that chondrocalcinosis was positively associated with osteophyte size at multiple sites. Conclusion: In patients referred to hospital with knee OA different patterns of osteophyte direction are discernible. Osteophyte size is associated with local compartmental narrowing but also local alignment and attrition. Chondrocalcinosis is associated with osteophytosis throughout the joint. These data suggest that both local biomechanical and constitutional factors influence the size and direction of osteophyte formation in knee OA.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

See 1 more Smart Citation

Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study

Nagaosa

2002

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

show abstract

“…We also found that the correlation of osteophyte formation to the degree of cartilage loss is significant but weak (correlation coefficient ranging from 0.22 to 0.41, P less than 0.01). Previous studies found significant association between the degree of osteophyte formation and cartilage lesion [2,17]. Boegard et al [2] found strong association between radiographically diagnosed osteophytes and cartilage defects detected by MRI.…”

Section: Discussionmentioning

confidence: 98%

Is the degree of osteophyte formation associated with the symptoms and functions in the patellofemoral joint in patients undergoing total knee arthroplasty?

Han

Chang

Choi

et al. 2006

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

Osteophyte formation and loss of articular cartilage are the main pathologic features of osteoarthritis in the patellofemoral joint. The goal of this study was to determine whether the degree of osteophyte formation was associated with the degree of cartilage loss and the patellofemoral symptoms and functions in osteoarthritic patients undergoing total knee arthroplasty (TKA). We evaluated 71 knees in 54 consecutive patients who underwent TKA under the diagnosis of osteoarthritis. The degree of patellofemoral osteophyte formation was assessed by proportional diameter and proportional rim involvement. The cartilage status was assessed by depth and size of the cartilage lesion. The patellofemoral symptoms and functions included anterior knee pain, abilities of chair-rising and stair-climbing and quadriceps muscle power. No significant association was found between the degrees of patellar or trochlear osteophyte formation with anterior knee pain or any of the patellofemoral functional parameters (P>0.05). The degree of osteophyte formation in the patella and the trochlea had a significant but weak correlation with the status of patellar cartilage and the status of the trochlear cartilage, respectively (correlation coefficient = 0.22-0.41 and P<0.05). This study indicates that physicians need to be cautious not to easily reach the conclusion that the patellofemoral symptoms and functional disabilities can be attributed to the presence of osteophyte in the patellofemoral joint in consulting patients with the patellofemoral radiographs or deciding on patellar resurfacing in TKA.

show abstract

“…injection of collagenase is an established model of OA that has been predominantly used to study the mechanisms underlying structural joint damage [15-17]. Histopathological alterations of the knee joint very similar to those observed in human OA have been described for this model, particularly in mice [18,19] and rabbits [20], as well as in the lumbar facet joint of rats [21].…”

Section: Introductionmentioning

confidence: 99%

Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis

et al. 2014

View full text Add to dashboard Cite

IntroductionAnimal models currently used in osteoarthritis-associated pain research inadequately reproduce the initiating events and structural pathology of human osteoarthritis. Conversely, intra-articular injection of collagenase is a structurally relevant model, as it induces articular degeneration both by digesting collagen from cartilage and by causing articular instability, thereby reproducing some of the main events associated with osteoarthritis onset and development. Here, we evaluated if the intra-articular injection of collagenase can be an alternative model to study nociception associated with osteoarthritis.MethodsOsteoarthritis was induced by two intra-articular injections of either 250 U or 500 U of collagenase into the left knee joint of adult male Wistar rats. A six weeks time-course assessment of movement- and loading-induced nociception was performed by the Knee-Bend and CatWalk tests. The effect of morphine, lidocaine and diclofenac on nociceptive behaviour was evaluated in animals injected with 500 U of collagenase. Joint histopathology was scored for both doses throughout time. The expression of transient receptor potential vanilloid 1 (TRPV1) in ipsilateral dorsal root ganglia (DRG) was evaluated.ResultsAn increase in nociceptive behaviour associated with movement and loading of affected joints was observed after intra-articular collagenase injection. With the 500 U dose of collagenase, there was a significant correlation between the behavioural and the histopathological osteoarthritis-like structural changes developed after six weeks. One week after injection of 500 U collagenase, swelling of the injected knee and inflammation of the synovial membrane were also observed, indicating the occurrence of an early inflammatory reaction. Behavioural changes induced by the 500 U dose of collagenase were overall effectively reversed by morphine and lidocaine. Diclofenac was effective one week after injection. TRPV1 expression increased six weeks after 500 U collagenase injection. ConclusionWe conclude that the intra-articular injection of 500 U collagenase in the knee of rats can be an alternative model for the study of nociception associated with osteoarthritis, since it induces significant nociceptive alterations associated with relevant osteoarthritis-like joint structural changes.

show abstract

The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee

Cited by 38 publications

References 26 publications

Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study

Characterisation of size and direction of osteophyte in knee osteoarthritis: a radiographic study

Is the degree of osteophyte formation associated with the symptoms and functions in the patellofemoral joint in patients undergoing total knee arthroplasty?

Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis

Contact Info

Product

Resources

About