The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold

Asghari, Golaleh; Yuzbashian, Emad; Wagner, Carol L.; Mahdavi, Maryam; Shamsi, Roya; Hosseinpanah, Farhad; Mirmiran, Parvin

doi:10.1371/journal.pone.0225717

Cited by 15 publications

(8 citation statements)

References 47 publications

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“…Although serum calcium and phosphate level were low in the CG, they were still within the normal range. Several investigators found a balanced level of Ca and P in spite of low levels of vitamin D 3, due to the higher level of parathyroid hormone which stimulates calcium and phosphate reabsorption from kidneys [ 39 – 42 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D3 on the Alignment of Mandibular Anterior Teeth: A Randomized Controlled Clinical Trial

Al-Attar

Abid

2022

International Journal of Dentistry

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Objectives. To investigate the effect of vitamin D3 level on the alignment of mandibular anterior teeth in adults and explore the associated root resorption and pain perception. Trial Design. Multicentre, double blinded randomized clinical trial. Subjects and Methods. Adult patients aged 18–30 years, with moderate mandibular incisor crowding [Little’s Irregularity index (LII) 3–6 mm], needing nonextraction treatment with fixed orthodontic appliance, were randomly allocated into two groups with 1 : 1 allocation ratio. In the 1st group (normal vitamin D3 level group [ND3G]), vitamin D level was measured and corrected to normal before starting orthodontic treatment, while in the 2nd group [control group (CG)] the vitamin D level was kept unknown until completion of the alignment phase. Outcome measures included mandibular incisor crowding using LII, orthodontically induced root resorption (OIRR), and pain perception. Independent sample t-test was used to compare the duration of treatment, the effectiveness of alignment, and OIRR between groups, while differences in pain perception were analysed by Mann–Whitney U-test ( P < 0.05 ). Results. Out of 87 patients recruited from four centres, 33 patients were randomly allocated into two groups (17 patients to ND3G and 16 patients to CG). Time elapsed for the complete alignment of the mandibular incisor crowding was one month shorter in ND3G (23.532% faster), and the improvement percentage was significantly higher in all periods when compared to the CG. The amount of OIRR was not significantly different between groups; however, pain during the first three days of alignment was significantly less in ND3G. Conclusions. Having optimal vitamin D3 level reduced the alignment time and pain associated with orthodontic treatment, but it had no role in reducing OIRR. Registration. The trial was registered with ClinicalTrials.gov on 12th April 2021 (registration number: NCT04837781).

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Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D3 on the Alignment of Mandibular Anterior Teeth: A Randomized Controlled Clinical Trial

Al-Attar

Abid

2022

International Journal of Dentistry

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“…While vitamin D will function to help balance calcium in the blood when parathyroid hormone has converted vitamin D into a hormonal form of vitamin D in the kidneys. 31 • 32 .…”

Section: Effects Of Vitamin D Supplementation On Biochemical Results Concentration Of Serum 25 (Oh) D and Serum Calciummentioning

confidence: 99%

The Effects of Vitamin D Supplementation on Serum Levels of 25 (OH) D, Serum Calcium, and Bone Density in Adolescent: A Literature Review

Jufri

Nurmaladewi

Nirmala

2021

AMNT

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Latar Belakang: Stunting dan penurunan densitas tulang merupakan salah satu masalah gizi yang umum diderita oleh remaja. Hal ini terjadi akibat kurangnya asupan zat gizi yang adekuat terutama vitamin D yang berfungsi untuk pertumbuhan tulang dan mineralisasi jaringan. Jumlah yang terbatas dari makanan dan faktor pigmentasi kulit menjadi penyebab terjadinya defisiensi vitamin D sehingga dibutuhkan upaya suplementasi untuk memenuhi kebutuhan tersebut.Tujuan: Untuk menganalisis efek suplementasi vitamin D terhadap pertumbuhan linier remaja.Metode: Penelusuran artikel pada tinjauan pustaka ini dilakukan menggunakan mesin pencarian melalui Medline, PubMed, EBSCO, ELSEVIER, Cambridge Core, dan WILEY. Artikel memuat teks penuh, berbahasa inggris dan tahun terbit mulai dari 2010 hingga 2020. Kata kunci pencarian yang dimasukkan adalah vitamin D supplementation, adolescent or teenagers, linear growth, dan Bone Mass Density (BMD).Hasil: Hasil skrining menemukan 12 artikel yang memenuhi kriteria inklusi dan diklasifikasikan berdasarkan luaran penelitian yaitu kadar serum 25(OH)D merupakan parameter biokimia yang merupakan luaran yang terdapat pada 10 artikel penelitian. Parameter biokimia serum kalsium sebanyak 6 artikel, densitas tulang sebanyak 8 artikel, dan tinggi badan 2 artikel.Kesimpulan: Suplementasi vitamin D yang diberikan pada remaja yang sehat maupun tidak sehat terbukti meningkatkan kadar serum 25(OH)D.Kata kunci: Suplementasi vitamin D, serum 25(OH)D, densitas massa tulang, pertumbuhan linier remaja. ABSTRACT Background: Stunting and decreased bone density are some of the common nutritional problems that remain by adolescents. This occurs due to lack of adequate nutrition, especially vitamin D which functions for bone growth and tissue mineralization. A limited amount of food and skin pigmentation factors cause vitamin D deficiency so supplementation efforts are needed to meet those needs.Objective: To analyze the effect of vitamin D supplementation on the linear growth of adolescents.Method: Searching for articles in this literature review was done using a search engine through Medline, PubMed, EBSCO, ELSEVIER, Cambridge Core, and WILEY. The article contains the full text, English language, and year of publication from 2010 to 2020. The search keywords entered are vitamin D supplementation, adolescent or teenagers, linear growth, and Bone Mass Density (BMD).Results: The screening results found 12 articles that met the inclusion criteria and were classified based on research outcomes, namely serum 25 (OH) D levels were biochemical parameters which were the results contained in 10 research articles. Biochemical parameters of serum calcium were 6 articles, bone density were 8 articles, and height were 2 articles.Conclusion: Vitamin D supplementation given to healthy and unhealthy adolescents has been shown to increase serum 25 (OH) D levels.Keywords: Vitamin D supplementation, serum 25 (OH) D, bone mass density, adolescent linear growth.

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“…Esmaili et al pointed out that a higher level of 25(OH)D of 30 ng/mL was a risky inflection point [18]. Other studies set up suitable VitD levels for overweight/obesity or metabolism disorder in children on the basis of their study population, and inflection values varied, ranging from 10 ng/mL to 32 ng/mL [44,45]. In one review, the authors recommended maintaining serum 25(OH)D levels >30 ng/mL in pediatrics to prevent VitD deficiency, thus avoiding the risk of both skeletal and extraskeletal diseases [46].…”

Section: Discussionmentioning

confidence: 99%

Association between Suboptimal 25-Hydroxyvitamin D Status and Overweight/Obesity in Infants: A Prospective Cohort Study in China

et al. 2022

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This study aimed to investigate whether 25-hydroxyvitamin D (25(OH)D) concentrations are correlated to overweight/obesity in infants and to explore a threshold of 25(OH)D. A total of 1205 six-month-old infants from two community hospitals in Shanghai were randomly recruited, and 925 of them were followed up at 12 months. Concentration of 25(OH)D, weight, and length were measured at two time points. Overweight/obesity was defined as a weight-for-length Z-score >97th percentile. The prevalence of overweight/obesity at 6 and 12 months was 6.88% and 5.26%, respectively. The occurrence of vitamin D (VitD) deficiency (<20 ng/mL) at 6 and 12 months was 6.56% and 2.05%, respectively. Concentration of 25(OH)D at the corresponding age was negatively associated with weight-for-length percentile (WLP) at both 6 (adjusted β: −0.14; 95% CI: −0.27, −0.02; p = 0.02) and 12 months (adjusted β: −0.22; 95% CI: −0.41, −0.02; p = 0.03), while the relationship between 25(OH)D at 6 months and WLP at 12 months was nonlinear, where 35 ng/mL was identified as an inflection point. Those with a concentration of 25(OH)D <35 ng/mL at 6 months had a higher risk of overweight/obesity (adjusted OR: 1.42; 95% CI: 1.06, 1.91; p = 0.02) compared to the group with a concentration of 25(OH)D ≥35 ng/mL. Moreover, a concentration of 25(OH)D <35 ng/mL at two time points significantly increased the risk of overweight/obesity at 12 months compared to the group with 25(OH)D concentration ≥35 ng/mL at two time points (adjusted OR: 2.91; 95% CI: 1.13, 7.46; p = 0.03). A suboptimal 25(OH)D concentration <35 ng/mL significantly increases the risk of overweight/obesity in infants.

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The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold

Cited by 15 publications

References 47 publications

The Effect of Vitamin D3 on the Alignment of Mandibular Anterior Teeth: A Randomized Controlled Clinical Trial

The Effect of Vitamin D3 on the Alignment of Mandibular Anterior Teeth: A Randomized Controlled Clinical Trial

The Effects of Vitamin D Supplementation on Serum Levels of 25 (OH) D, Serum Calcium, and Bone Density in Adolescent: A Literature Review

Association between Suboptimal 25-Hydroxyvitamin D Status and Overweight/Obesity in Infants: A Prospective Cohort Study in China

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