The Relation between Diabetes Type II and Anemia

Aljohani, Abdulmajeed Hassan; Alrubyyi, Methaq Abdullah; Al-Harbi, Abdullah; Alomair, Abdullatif Mohammed; Alomair, Abdulrahim Abdullatif; Aldossari, Nourah Ali; Alghamdi, Saleh Khader; Alawaji, Sulaiman Abdullah; Alamri, Samar Ali Sager; Tallab, Omar Talal M; Alsaiari, Abdulaziz Y; Qashqari, Jehad Jamil T

doi:10.12816/0043795

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…55,[60][61][62] In addition, normocytic normochromic anemia might suggest the significance of the renal origin of anemia in diabetic patients. 6,7,63,64 Considering the percentage of anemic patients with altered renal function in this study, the above explanation seems acceptable. Renal impairment leads to anemia though impaired production of erythropoietin by peritubular fibroblast of the kidney, [65][66][67] urinary erythropoietin losses, 68 reduced RBC life span due to uremic environment and the possible role of circulating uremic-induced prevention of erythropoiesis.…”

Section: Discussionmentioning

confidence: 76%

<p>Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study</p>

Taderegew¹,

Gebremariam²,

Tareke³

et al. 2020

JBM

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Purpose: Anemia is one of the common complications of diabetes mellitus (DM), which has an adverse effect on the progression and development of other diabetes-related complications. In spite of this, relatively little information is available on the prevalence of anemia and associated factors among type 2 diabetes mellitus (T2DM) patients in Ethiopia, particularly in the study area. Thus, this study assessed the prevalence of anemia and associated factors among T2DM patients at Debre Berhan Referral Hospital (DBRH), NorthEast , Ethiopia. Patients and Methods: A hospital-based cross-sectional study was conducted from April 1 to May 30, 2019, among 249 T2DM patients with follow up at DBRH, selected using a systematic random sampling technique. Data were collected by face-to-face interviews, anthropometric measurements, and laboratory tests; such as hemoglobin measurements, red blood indices, and serum creatinine analysis. The data were coded and entered into Epi-data manager version 4.4.1.0, and analysis by using SPSS version 22 was carried out. To identify the determinant factors of anemia, bivariate and multivariate logistic regression analyses were performed. P-value <0.05 was considered as statistically significant. Results: The study showed 20.1% of the participants were anemic. Being age >60 years (AOR=3.06, 95% CI: 1.32-7.11), poor glycemic control (AOR=2.95, 95% CI: 1.22-7.15), eGFR 60-89.9 mL/min/1.73m 2 (AOR=2.91, 95% CI: 1.15-7.37), eGFR <60 mL/min/1.73m 2 (AOR=6.58, 95% CI: 2.42-17.93), DM duration >10 years (AOR= AOR=2.75, 95% CI: 1.17-6.48), and having diabetic complications (AOR=3.81, 95% CI: 1.65-8.81) were significantly associated with anemia. Conclusion: One out of five T2DM patients had anemia. Poor glycemic control, decreased eGFR, presence of DM complications, duration of DM >10 years, and age >60 years were significantly associated with the occurrence of anemia among T2DM. Regular screening for anemia in all T2DM patients may help in the early detection and management of anemia.

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Section: Discussionmentioning

confidence: 76%

<p>Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study</p>

Taderegew¹,

Gebremariam²,

Tareke³

et al. 2020

JBM

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“…Fe levels in the T2DM group was significantly lower than other groups. Several studies showed a significantly lower Fe concentration in the T2DM patients when compared to the healthy controls [ 15 , 16 , 24 , 28 ]. Fe supplementation is suggested to be a target therapy for patients at risk of T2DM [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fe supplementation is suggested to be a target therapy for patients at risk of T2DM [ 24 ]. A study by Aljohani et al, 2018, showed that a high incidence of anemia is more likely to occur in patients with poorly regulated diabetes and in T2DM patients with renal insufficiency [ 28 ]. Naqash et al reported that lower levels of serum Fe have been associated with higher levels of HbA1c [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia

et al. 2021

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The homeostasis of trace elements were observed to contribute to certain diabetic outcomes. This cross-sectional study determined the differences and associations between serum levels of copper (Cu), iron (Fe) and zinc (Zn) in Saudi patients with and without type 2 diabetes mellitus (T2DM) as well as those with prediabetes. Anthropometrics were measured, and fasting blood samples were collected from 119 patients with T2DM (aged 41–64 years), 95 non-T2DM (aged 27–55 years) and 80 with prediabetes (aged 35–57 years). Circulating trace minerals were determined using an inductively coupled plasma–mass spectrometer. Serum levels of Cu and Fe were significantly lower in T2DM than non-T2DM (adjusted p-values < 0.001). There was no difference in the Zn levels of the T2DM and non-T2DM groups. The serum Cu levels were significantly lower in the prediabetes group than the non-T2DM group (p < 0.05). The serum levels of Cu, Fe and Zn were inversely associated with circulating glucose in the T2DM and prediabetes subjects (p-values < 0.001). In conclusion, the differences in circulating trace elements were observed in Saudi subjects with varying glycemic statuses, suggesting an inverse association between T2DM progression and the decreasing serum Cu, Fe and Zn levels. Intervention trials are warranted to determine whether early correction of trace mineral deficiencies is beneficial in populations at higher risk for T2DM.

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“…6 Several studies have reported factors that increase the risk of anaemia, which include damage to renal interstitium due to chronic hyperglycaemia and consequent formation of advanced glycation end products by increased reactive oxygen species, and systemic inflammation as well as reduced androgen levels induced by diabetes as shown by Adejumo et al, and Fetch et al in 2016. 6,[8][9] Andrews and Arredono determined that the presence of anaemia in type 2 diabetes as well as evaluating the expression of genes related to inflammation and immune response. The results found by the authors demonstrate that diabetic patients with anaemia exhibit increased expression of proinflammatory cytokines as compared to diabetic patients only.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of anaemia with the degree of glycaemic control in type 2 diabetes mellitus

Prabhu

Teli

2019

Int J Adv Med

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Background: Anaemia is one of the world’s most common preventable condition yet it is often overlooked especially in people with Diabetes Mellitus. Anaemia is a common finding in patients with diabetes. Anaemia in patients with diabetes mellitus might contribute to the pathogenesis and progression of cardiovascular disease and aggravate diabetic nephropathy and retinopathy. This aims to study the correlation between HbA1c and blood glucose levels in anaemic diabetics in order to assess the influence of anaemia on HbA1c and the effect of severity and type of anaemia on HbA1c.Methods: It’s a case control study, 200 Diabetic subjects were divided into two groups of 100 each based on their HbA1c levels group A, with good glycaemic control (HbA1c<7) and group B with poor glycaemic control (HbA1c>7), incidence of anaemia was measured and compared among them and also with 100 age and sex matched healthy non Diabetic controls. Results: In this study, it was found that high incidence of anaemia was found significantly higher in diabetics group with poor glycaemic control. Anemia was detected in 55% of patients among diabetic patients. Anaemia was seen in 71% of patients in group B with poor glycaemic control as compared to group A with good glycaemic control, in which only 39% of patients had anaemia. Mean haemoglobin was significantly lower that is, 10.81±3.0 in group with poor glycaemic control as compared to group with good glycaemic control i.e. 13.04±2.02. There was a statistically significant negative correllation between Haemoglobin percentage and HbA1c.Conclusion: Anaemia is a common finding in patients with diabetes. Diabetes related chronic hyperglycaemia can lead to a hypoxic environment in the renal interstitium which results in impaired production of erythropoietin by the peritubular fibroblasts and subsequently anaemia occurs. Anaemia in patients with diabetes mellitus might contribute to pathogenesis and progression of cardiovascular disease and aggravate diabetic nephropathy and retinopathy. However, an emphasis on regular screening for anaemia, alongside that for other diabetes related complications, might help to delay the progression of vascular complication in these patients.

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The Relation between Diabetes Type II and Anemia

Cited by 10 publications

References 15 publications

<p>Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study</p>

<p>Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study</p>

Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia

A comparative study of anaemia with the degree of glycaemic control in type 2 diabetes mellitus

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