The Relation of Cirrhosis of the Liver to Renal Hypertension

The haemodynamic response to propranolol in cirrhosis with arterial hypertension: a comparative analysis with normotensive cirrhotic patients

“…21,22 Studies on arterial hypertension in patients with cirrhosis show that the frequency is reduced, with a prevalence of raised arterial blood pressure of 3-7%. [3][4][5][6]9 Our study reported a frequency of 8%. This apparently high frequency may be due to referral bias.…”

“…In hypertensive cirrhotic group, the median post-therapy HVPG in responders was 13 (8-21) mmHg, while in nonresponders it was 18 (13)(14)(15)(16)(17)(18)(19)(20)(21)(22) mmHg. In normotensive cirrhotic group, the median post-therapy HVPG in responders was 12 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) mmHg, while in nonresponders, it was 18 (13-30) mmHg (Figure 1). …”

“…Arterial hypertension is found in about 10% of patients with cirrhosis. 5,9 Patients with cirrhosis and portal hypertension eventually develop a hyperdynamic circulation, with high cardiac output and reduced systemic vascular resistance (SVR). This haemodynamic alteration is thought to be involved in the pathogenesis of sodium retention and ascites, 10 which has been observed in 80% of cirrhotic patients after many years of disease.…”

Predicting tissue-specific expressions based on sequence characteristics

“…As depicted in Table 1, we defined the target-expressing tissues as being functionally related if the comparison had a P value less than the Bonferroni corrected P value (8E-03). Jaccard's index for kidney-specific and liver-specific genes was 0.09, with a significant P value (2E-04), which was consistent with the functional relatedness of the liver and kidney (28)(29)(30). Similarly, the brain-and testis-specific gene domains reflected the developmental interdependence of the brain and testis (31).…”

Arterial hypertension in cirrhosis: arterial compliance, volume distribution, and central haemodynamics

“…[7][8][9][10] In line with these observations, arterial hypertension of renal vascular origin seldom becomes manifest in cirrhotic patients with organic renal disease. 11 Gentilini et al found, based on non-invasive methods, that cirrhotic patients with arterial hypertension were normokinetic and showed fewer signs of renal impairment, 12 and Veglio et al found signs of enlarged effective plasma volume (PV) in hypertensive cirrhotic patients. 13 The present study was undertaken to investigate the central haemodynamics of patients with cirrhosis and arterial hypertension, using direct methods, to determine the degree of central filling and normo-or hyperkinetics.…”