The Relation of Liver Stores to the Occurrence of Early Signs of Vitamin A Deficiency in the White Rat

Brenner, Sadie; Brookes, Margaret C. Hessler; Roberts, Lydia J.

doi:10.1093/jn/23.5.459

Cited by 28 publications

(13 citation statements)

References 19 publications

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“…For example, when large amounts are ingested, only a small fraction can be accounted for by fecal excretion, storage in the liver, and daily requirement (15,16). Again, data which we have previously obtained (17), as well as those of Brenner, Brookes, and Roberts (18), indicate that, during depletion, vitamin A is released from the liver of the rat in amounts much greater than that required by the animal.…”

Section: Methodssupporting

confidence: 67%

The Concentration of Vitamin a in the Blood Plasma During Pregnancy 1

Bodansky¹,

Lewis²,

Lillienfeld³

1943

J. Clin. Invest.

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The effect of pregnancy upon metabolism is reflected in various ways, notably in the changes in concentration of many blood components (1,2,3). The manner in which pregnancy affects the blood levels of the vitamins has been studied in detail only in the case of vitamin C (4, 5). In view of several recent studies on the regulation of the plasma level of vitamin A (6 to 9), it was considered of value to investigate systematically the concentration of this vitamin during the course of pregnancy. EXPERIMENTALPlasma vitamin A and carotene determinations were carried out in 120 women at various stages of pregnancy. In 12 of these, the blood plasma was analyzed at some time during the first 2 trimesters and again in the ninth month. The subjects were advised to eat their usual diets and a record of their dietary intake, especially with regard to vitamin A-containing foods, was kept. No carotene or vitamin A concentrates were added to the diet.

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Section: Methodssupporting

confidence: 67%

The Concentration of Vitamin a in the Blood Plasma During Pregnancy 1

Bodansky¹,

Lewis²,

Lillienfeld³

1943

J. Clin. Invest.

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“…The more frequent higher doses administered to animals in this group had resulted in incomplete serum clearance despite increased liver storage of absorbed vitamin A. It has been shown that normally the serum level of vitamin A is maintained relatively constant and does not reflect the liver store (BRENNER and BROOKS, 1942;GLOVER et al, 1947). Also no direct relationship has been demonstrated between severity of clinical symptoms and serum levels (RODAHL, 1950).…”

Section: Discussionmentioning

confidence: 87%

“…Confirmation that hypervitaminosis A occurred was made by serum and liver Vitamin A determinations. Values reported elsewhere as normal for vitamin A content range from 8.5 to 112 i.u./lOO ml of serum, and from 27 to 113 i.u./g of liver (BRENNER and BROOKS, 1942;GLOVER, GOODWIN and MORTON, 1947;LEWIS et al, 1942). Although both groups A (long-term, subtoxic hypervitaminosis) and B (control) had similar normal serum values, liver values differed significantly, which indicated that group A rats were hypervitaminotic.…”

Section: Discussionmentioning

confidence: 96%

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Morphologic effects of hypervitaminosis a on rat submandibular gland

Regezi

Rowe

1972

Archives of Oral Biology

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Young male Sprague-Dawley rats were fed oral supplements of vitamin A; either a subtoxic dose of 5000 i.u./day for 16 weeks (10 animals), or a toxic dose of 15,OOOi.u./day for 16 days (5 animals). High-dose animals exhibited signs of acute toxicity; low-dose animals demonstrated only less weight gain than controls. Vitamin A sera and liver levels evidenced intoxication. Light and electron microscopy were conducted upon acini, intercalated ducts, and striated-granular ducts of the submandibular gland. Acinar cells evidenced rough endoplasmic reticulum clefting and hyperplasia of both rough endoplasmic reticulum and Golgi apparatus similar to changes produced by pilocarpine or isoproterenol and interpreted as hyperactivity. Also increased were the number of degenerating acinar cells. Striated-granular duct cells were similar to controls except for increased cellular degeneration. Intercalated ducts appeared unaffected. Abnormalities were more pronounced in short-term, toxic hypervitaminosis A than long-term, subtoxic hypervitaminosis A.

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“…Paradoxically, the only study on the opposite sex has been carried out in the human species and on two women only. [25] However, it has been known for many years that there are differences in the metabolism of VA between the two sexes [26,27] . Indeed, it has been shown that retinolemia is lower in females than in males, both in rodents [26,28] and in humans [27] .…”

Section: ) Introductionmentioning

confidence: 99%

β‐Carotene Bioavailability and Conversion Efficiency Are Significantly Affected by Sex in Rats

Borel

Troadec

Damiani

et al. 2021

Molecular Nutrition Food Res

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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The Relation of Liver Stores to the Occurrence of Early Signs of Vitamin A Deficiency in the White Rat

Cited by 28 publications

References 19 publications

The Concentration of Vitamin a in the Blood Plasma During Pregnancy 1

The Concentration of Vitamin a in the Blood Plasma During Pregnancy 1

Morphologic effects of hypervitaminosis a on rat submandibular gland

β‐Carotene Bioavailability and Conversion Efficiency Are Significantly Affected by Sex in Rats

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