The Relation of the Internal Secretions to Tumor Metabolism*

Meyer, Ovid O.; McTiernan, Claire; Aub, Joseph C.

doi:10.1210/endo-17-4-363

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…The age of the mice at the time of the experiments varied between 3 and 15 months, by far the greater number being 4 to 8 months old, and the average about 7 months. It has been found (12), however, that within rather wide limits the age of the mouse has little effect upon the metabolism of the isolated tissues. This confirms Hawkins (13) The measurements of the metabolism were made with the Warburg modification of the Haldane-Barcroft blood gas apparatus.…”

Section: Methods Of Studymentioning

confidence: 99%

The Effect of Thyroxin Upon the Metabolism of Isolated Normal and Malignant Tissue

Meyer¹,

McTiernan²,

Aub³

1933

J. Clin. Invest.

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In the course of an extended study of the influence of the internal secretions upon tissue metabolism, the thyroid influence seemed particularly significant. Here, therefore, is presented a detailed report of its effect not only upon a parasitic tumor tissue, but also upon the liver tissue of the host.The effect of the hormones upon tumor growth has been investigated extensively by others but the effect upon the metabolism of the tumor has received little or no attention. Several reports of the effect of thyroxin upon the metabolism of various normal isolated tissues have been made since 1924, but the results have been somewhat contradictory. Ahlgren (1) reported that thyroxin increased the metabolic rate of tissues of frogs in vitro as measured by acceleration of the reduction of methylene blue. In 1925 he reported that thyroxin increased the oxygen consumption of thyroid-deprived muscle, and pituitrin in proper concentration acted similarly. Reinwein and Singer (2) found an increase in the oxygen consumption of surviving liver cells after addition in vitro of thyroid extract but Paasch and Reinwein (3) found no effect upon the surviving diaphragm of the rat. Wohlgemuth and Klopstock (4) noted very striking increases in the oxygen consumption of skin with inhibition of anaerobic glycolysis after administration in vitro of thyroid. Hopping (5) reported increase in the metabolism of alligator blood of 150 to 190 per cent after injection of thyroxin but no effect from the direct addition of this substance to the blood.Fleischmann (6) found slight increase in the glycolysis of leukocytes in exudate of animals but unchanged respiration after administration in vitro of thyroxin. Anselmino, Eichler and Schlossmann (7) noted maximum effects of injected thyroxin upon isolated kidney tissues at the end of 72 hours. This effect was chiefly an increase in the anaerobic glycolysis. They discerned no significant increase in the oxygen consumption of liver or spleen and only slight increase in the oxygen consumption of kidney. The anaerobic glycolysis in the liver and spleen was not increased. Dresel (8), however, a year before, reported somewhat different results in isolated rat tissues after injection of thyroxin. He noted an increase in the oxygen consumption of liver as great as 200 per cent on the third day after the injection with slight decrease in the anaerobic glycolysis. The oxygen con-723

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Section: Methods Of Studymentioning

confidence: 99%

The Effect of Thyroxin Upon the Metabolism of Isolated Normal and Malignant Tissue

Meyer¹,

McTiernan²,

Aub³

1933

J. Clin. Invest.

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“…Foster [1926] observed that thyroidectomy produced a diminished O2 uptake of muscle tissue respiring in glucose, a result also reported by Dye & Maughan [1929a, b] with and without the addition of succinate to the respiring muscle mince. Many workers have reported increases in O2 uptake of surviving tissues after treating animals with thyroxine or thyroid preparations; notably Dresel [1928] in kidney and liver, Anselmino, Eichler & Schlossmann [1929] in liver, spleen and kidney, Hopping [1930] in alligator red blood cells, Hicks [1932] in muscle, McEachern [1932] in heart, Dye [1933] in muscle, Gerard & McIntyre [1933] in liver, auricle and vagus nerve, Meyer, McTiernan & Aub [1933] in liver, Ebina [1932] in liver and kidney, McEachern [1935] in kidney, liver and muscle, Khayyal & Scott [1935] in uterus and Victor & Andersen [1938] in liver and kidney. As far as is known, the only work on the respiration of brain tissue following thyroid treatment is that of Cohen & Gerard [1937].…”

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confidence: 99%