One of the foundational gestures of the disability rights movement was the rejection of the common description of people who live with physical or mental impairments as "eternal children." This paper argues that the contradictions inherent in applying this trope to adults amplify the contradictions inherent in applying it to children themselves. From its heyday in in the 19th-century "Golden Age" of children's literature to its afterlife in 20th-century disabling rhetoric, the fantasy of childhood as stasis requires denying the fact of growth.

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Renal and pulmonary neoplasms developed in male and female Sprague-Dawley rats fed a diet containing 125 ppm dimethylnitrosamine (DMN) for longer than 80 days. The tumors found in the kidneys can be classified into two types: (a) benign solid and cystic adenomas occurring in rats fed DMN for less than 160 days; (o) anaplastic (possibly malignant) epithelial tumors in animals treated longer than 160 days. Charac teristic nuclear alterations were observed in the cells of the proximal convoluted tubules and are interpreted as the earliest morphological manifestation in the kidney of DMN intoxication.

Numcrous attempts havc bccn made to establish a relationship between the pituitary gland and tumor growth. Zondek and his coworkers (1) and Cannavo ( 2 ) concluded from their experimental work that the growth of graftcd tumors could be inhibited or retarded by injections of prolan. This could not be confirmed by Krehbiel, Haagensen, and Plantenga ( 3 ) , nor by Suginra and Benedict (4), nor by Wiesncr and Haddow (5). Gross ( G ) , on the other hand, observed slightly accclerated growth in mouse sarcoma when using comparatively small doses of prolan ; and BischofT and his co-workers (7) found that standardized growth-promoting preparations of the pituitary significantly accclerated the ratc of growth of carcinoma 256 in older rats. Bischoff and his associates (7) also found that pituitary irradiation retarded the growth rate of grafted tumors in rats and mice. Ball, Samuels, and Simpson (8, 9) reported a smaller percentage of takes and a retardation of growth of the Walker transplantable mammary carcinoma in hypophysectomized rats. McEuen and Thomson (10) found that hypophysectomy retarded but did not prevent the growth of the Walker rat tumor, and also found that semi-starvation, similar to that which obtains in hypophysectomized rats, resulted in a retardation of tumor growth equivalent to that produced by hypophysectomy.No study appears to have been made, however, of the effect of removal of the pituitary gland upon the metabolism of transplanted tumor tissue. Studies of tumor tissue metabolism in mice after removal of the testicles, thyroid glands, and suprarenal glands have been reported by Meyer, McTiernan, and Rub (11). Since hypophysectomy has been shown to induce a lowering of general body metabolism (12), an investigation was made to see whether this effect also obtained in the metabolism of transplanted tumor tissue in the rat. hf ETHODSFourteen inbred, pure-strain, albino, male rats were hypophysectomized by the parapharyngeal route when their weights were between 80 and 100 grams. Litter-mate controls were set aside. Between two and four wceks after operation when, by stationary body weight and atrophy and retraction of the testiclcs, it became obvious that complete hypophysectomy had been effected, tumor transplants of the Walker rat carcinoma No. 256 were placed beneath the skin of both flanks. The tumors had usually reached sufficient size in both the hypophysec-106

In the course of an extended study of the influence of the internal secretions upon tissue metabolism, the thyroid influence seemed particularly significant. Here, therefore, is presented a detailed report of its effect not only upon a parasitic tumor tissue, but also upon the liver tissue of the host.The effect of the hormones upon tumor growth has been investigated extensively by others but the effect upon the metabolism of the tumor has received little or no attention. Several reports of the effect of thyroxin upon the metabolism of various normal isolated tissues have been made since 1924, but the results have been somewhat contradictory. Ahlgren (1) reported that thyroxin increased the metabolic rate of tissues of frogs in vitro as measured by acceleration of the reduction of methylene blue. In 1925 he reported that thyroxin increased the oxygen consumption of thyroid-deprived muscle, and pituitrin in proper concentration acted similarly. Reinwein and Singer (2) found an increase in the oxygen consumption of surviving liver cells after addition in vitro of thyroid extract but Paasch and Reinwein (3) found no effect upon the surviving diaphragm of the rat. Wohlgemuth and Klopstock (4) noted very striking increases in the oxygen consumption of skin with inhibition of anaerobic glycolysis after administration in vitro of thyroid. Hopping (5) reported increase in the metabolism of alligator blood of 150 to 190 per cent after injection of thyroxin but no effect from the direct addition of this substance to the blood.Fleischmann (6) found slight increase in the glycolysis of leukocytes in exudate of animals but unchanged respiration after administration in vitro of thyroxin. Anselmino, Eichler and Schlossmann (7) noted maximum effects of injected thyroxin upon isolated kidney tissues at the end of 72 hours. This effect was chiefly an increase in the anaerobic glycolysis. They discerned no significant increase in the oxygen consumption of liver or spleen and only slight increase in the oxygen consumption of kidney. The anaerobic glycolysis in the liver and spleen was not increased. Dresel (8), however, a year before, reported somewhat different results in isolated rat tissues after injection of thyroxin. He noted an increase in the oxygen consumption of liver as great as 200 per cent on the third day after the injection with slight decrease in the anaerobic glycolysis. The oxygen con-723