Robison, in 1923 (22), suggested that phosphatase plays an important r6le in the formation of bone in the human body. He found a very active phosphatase in preparatory areas of ossification, and held that this enzyme hydrolyzed the phosphoric esters in the blood to bring about a local increase in the concentration of the phosphate ions. It was his theory that the solubility product of tertiary calcium phosphate was thereby exceeded, and that deposition of this salt therefore occurred in the ossifying zone. Evidence has since accumulated, chiefly through the work of Robison and Kay and their associates, to strengthen this hypothesis and to make 1 Presented in abstract form before tlie meeting of the Society for Clinical Investigatioll at Atlantic City, N.

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