Nature of the Action of Testosterone on Genital Tract of the Immature Female Rat.

Nathanson, Ira T.; Franseen, Clifford C.; Sweeney, Aaron

doi:10.3181/00379727-39-10214

Cited by 17 publications

(5 citation statements)

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“…If stanozolol were acting via a central mechanism to advance VO, then it would most likely act indirectly through the ovaries to trigger VO, and yet stanozolol advanced VO in the absence of ovaries. This result is similar to those of previous experiments, where the treatment of ovariectomized prepubertal rats with aromatizable androgens advanced VO, ruling out an effect dependent on the function of the ovary [22][23][24]. In other experiments conducted in our laboratory, systemic administration of stanozolol induced central effects, as evidenced by changes in behavior [25,26].…”

Section: Mechanism and Site Of Actionsupporting

confidence: 91%

Effects of Acute Stanozolol Treatment on Puberty in Female Rats1

Whitney¹,

Clark²

2001

Biology of Reproduction

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The effects of anabolic-androgenic steroid (AAS) abuse on the onset of puberty in female adolescents are largely unknown. This study assessed the acute effects of one AAS, stanozolol, on pubertal onset in the female rat. A single injection of stanozolol (5 mg/kg) on Postnatal Day (PN) 21 advanced vaginal opening but did not alter the onset of vaginal estrus. Higher doses of stanozolol treatment (10 and 25 mg/kg) also advanced vaginal opening but had no effect on vaginal estrus. The advancement of vaginal opening by stanozolol (5 mg/kg) was prevented by the concomitant administration of the pure antiestrogen ICI 182,780 (1 mg/kg) on PN20-22. Administration of the androgen receptor antagonist flutamide (10 mg/kg twice daily) on PN20-22 had no effect on the advancement of vaginal opening by stanozolol. Stanozolol treatment also advanced vaginal opening in ovariectomized rats. Perivaginal injections of a low dose of stanozolol (0.05 mg) on PN21 and PN23 also advanced vaginal opening. These results suggest that stanozolol is acting directly at estrogen receptors in the vaginal epithelium to advance vaginal opening and that prepubertal stanozolol treatment does not induce true precocious puberty.

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Section: Mechanism and Site Of Actionsupporting

confidence: 91%

Effects of Acute Stanozolol Treatment on Puberty in Female Rats1

Whitney¹,

Clark²

2001

Biology of Reproduction

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“…Forsberg, J acobsohn and Norgren 11966] found that the perforation of the vaginal membrane, which occurs prematurely in rats injected with testosterone propionate at the age of 5 days, is the result of cornification in the centre of the membrane, as in normal perforation. The effect of injected androgen, at all ages examined, appears to be exerted directly on the vaginal membrane and nol indirectly via the ovaries, as it is evident also in injected castrates [Deanesly and Parkes, 1936;Rubinstein, Abarbanel and Nader, 1938;Nathanson, Franseen and Sweeney, 1938;Kikuyama, 1965;Colombo, 1968].…”

Section: Discussionmentioning

confidence: 88%

Vaginal opening and vaginal epithelium following ovariectomy in newborn rats

Gitlin¹

1974

Cells Tissues Organs

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“…I t was not surprising that testosterone has the same effect as estradiol in preventing AGP block of ovulation, because proper administration of androgens has been shown to cause vaginal opening, onset of puberty, and ovulation in immature rats (16)(17)(18)(19)(20)(21)(22)(23).…”

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confidence: 99%