The Relation of the Tricarboxylic Acid Cycle to Bacterial Infection: I. The Effect of Malonate on Salmonella Typhimurium Infections in Mice

Modification of Pullorum Disease in the Chick by Certain Tricarboxylic Acid Cycle Inhibitors and Intermediates

“…It is also of interest to compare these results with those obtained by Berry and Mitchell (1953a, b), who have shown that the same inhibitors and intermediates reduced survival time in mice infected with SalmoneUa typhimurium. Since the sane pattern of response develops in the two unrelated hosts, it is possible that the very similar endotoxins (Dooley and Holtman, 1956) of the infectious agents may be of marked significance in producing the pathological effects.…”

“…In recent years, a number of agents such as radiation, war gases, hormones, drugs and certain adjuvants have been employed to hasten infection. Berry and Mitchell (1953a, b) established that various inhibitors and intermediates of the Krebs cycle reduced survival time in mice infected with Salmonella typhimurium. They concluded that imbalance in the tricarboxylic acid (TCA) cycle increased susceptibility to the pathogen and provided a connection between host metabolism and infection.…”

Studies on the Potentiation of Exdotoxin in Mice by Exposure to Cold

“…Cold, for example, is known to produce physiological alterations (Culver, 1959;South, 1960;Fuhrman and Fuhrman, 1961;Hardy, 1961;Carlson, 1962) which might be fundamental in determining the response of an animal not only to toxins but to infectious challenge as vell. The latter becomes reasonable in light of the profound influence that changes in host metabolism are known to have on host-parasite interactions (SmithandDubos, 1956;Bauer et al, 1956;Berry and Mitchell, 1953a, 1953b, 1954Berry et al, 1954aBerry et al, , 1954bBerry, 1956;Garber, 1960). Because of the significance of specific changes in adrenal cortical activity in response to cold stress Hart, 1954a, 1954b) and to endotoxin poisoning (Duffy and Morgan, 1951), the behavior of cold exposed endotoxin poisoned mice treated with either cortisone acetate or adrenocorticotrophic hormone (ACTH) is analyzed in this report.…”