Purpose: Exercise capacity is a well known prognostic indicator in many clinical conditions. This study evaluates the clinical and exercise variables most determinant for estimating exercise capacity in liver transplant candidates.
Methods:This prospective cross-sectional study consisted of thirty patients who were scheduled for liver transplantation. Respiratory and peripheral muscle strengths were measured using a mouth pressure device and a hand-held dynamometer, respectively. Physical activity, fatigue, exercise capacity, physical performance, and quality of life of participants were assessed using the International Physical Activity Questionnaire, the Turkish version of the Checklist Individual Strength Questionnaire, the Six-minute Walk Test (6MWT), the 30-sec Sit-to-Stand Test, and the Liver Disease Symptom Index 2.0, respectively. Multivariate analysis was conducted to determine clinical factors predictive of exercise impairment.
Results:The participants achieved 62.9% of the predicted six-minute walk distance (6MWD). 6MWD was strongly correlated with age (r=−0.678, p<0.001), dyspnea before the 6MWT (r=−0.668, p<0.001), and chair stands (r=0.745, p<0.001). A moderate correlation was observed between 6MWD and maximal inspiratory pressure (r=0.532, p=0.002), maximal expiratory pressure (r=0.522, p=0.003), and shoulder flexion (r=0.479, p=0.007). Age and maximal expiratory pressure were identified as independent determinants of exercise capacity, accounting for 57.4% of the variance.
Conclusion:Assessing respiratory parameters may have a fundamental role in improving posttransplant outcomes in especially older liver transplant candidates.