The relationship between 67Ga accumulation and ATP metabolism in tumor cells in vitro

Higashi, Tomomitsu; Kobayashi, Masato; Wakao, Hiromi; Jinbu, Yoshinori

doi:10.1007/bf00254629

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Into the extracellular space, the 67 Ga complex binds with strong avidity to the lactoferrin and the siderophores, which are predominantly released by activated neutrophils and bacteria, thus causing its accumulation in areas affected by infections [25,26]. Nevertheless, considering the intense 67 Ga-citrate uptake also in presence of agranulocytes, it has to be considered that, similarly to 18 F-FDG, it is also absorbed by cells with an increased glucose metabolic rate [27]. For this reason, to detect opportunistic pulmonary infections and differentiate infections from Kaposi sarcoma or lymphomas in immunocompromised patients, the use of 67 Ga-citrate combined with thallium-201 chloride ( 201 Tl) has been proposed.…”

Section: Gallium-67 Citratementioning

confidence: 99%

Molecular Imaging of Pulmonary Inflammation and Infection

Giraudo

Evangelista

Fraia

et al. 2020

IJMS

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Infectious and inflammatory pulmonary diseases are a leading cause of morbidity and mortality worldwide. Although infrequently used in this setting, molecular imaging may significantly contribute to their diagnosis using techniques like single photon emission tomography (SPET), positron emission tomography (PET) with computed tomography (CT) or magnetic resonance imaging (MRI) with the support of specific or unspecific radiopharmaceutical agents. 18F-Fluorodeoxyglucose (18F-FDG), mostly applied in oncological imaging, can also detect cells actively involved in infectious and inflammatory conditions, even if with a low specificity. SPET with nonspecific (e.g., 67Gallium-citrate (67Ga citrate)) and specific tracers (e.g., white blood cells radiolabeled with 111Indium-oxine (111In) or 99mTechnetium (99mTc)) showed interesting results for many inflammatory lung diseases. However, 67Ga citrate is unfavorable by a radioprotection point of view while radiolabeled white blood cells scan implies complex laboratory settings and labeling procedures. Radiolabeled antibiotics (e.g., ciprofloxacin) have been recently tested, although they seem to be quite unspecific and cause antibiotic resistance. New radiolabeled agents like antimicrobic peptides, binding to bacterial cell membranes, seem very promising. Thus, the aim of this narrative review is to provide a comprehensive overview about techniques, including PET/MRI, and tracers that can guide the clinicians in the appropriate diagnostic pathway of infectious and inflammatory pulmonary diseases.

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Section: Gallium-67 Citratementioning

confidence: 99%

Molecular Imaging of Pulmonary Inflammation and Infection

Giraudo

Evangelista

Fraia

et al. 2020

IJMS

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“…Bei der Galliumszintigraphie ist bis heute der Aufnah memechanismus des Gallium nicht geklärt; die Auf nahme eines Transferrin-Gallium-Komplexes wird kon trovers diskutiert [20], Ausserdem sind Technetium und Gallium Substanzen, die nicht in physiologischen Stoff wechselvorgängen Vorkommen. Zusätzlich ist die Mög lichkeit der Lokalisation der Stoffwechselerhöhung durch die nur zweidimensionale Darstellung bei der "T c-und der 67Ga-Szintigraphie eingeschränkt.…”

Section: Diskussionunclassified

Proliferation und Fluordeoxyglukoseaufnahme bei HNO-Tumoren

Reisser

Haberkorn²,

Haag

et al. 1993

Otorhinolaryngol Nova

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Das biologische Verhalten maligner Tumoren kann durch die absolute Messung des Glukosestoffwechsels mit der Positronenemissionstomographie (PET) und Fluor-18-Deoxyglukose (FDG) in vivo untersucht werden. Bei 25 Plattenepithelkarzinomen im Kopf-Hals-Bereich wurde die Proliferationsrate zusÄtzlich flusszytometrisch bestimmt. Der Vergleich zwischen der FDG-Aufnahme und der Proliferationsrate zeigte zwei Gruppen mit jeweils unterschiedlich erhÖhter Glukoseaufnahme (Korrelation r = 0,7 bzw. r = 0,81). Dies lÄsst sich nicht nur durch den proliferationsabhÄngigen Energiebedarf der Zellen erklÄren. Die unterschiedliche Glukoseaufnahme kÖnnte durch molekulargenetische Unterschiede der histologisch vergleichbaren Tumoren sein. Diese Beobachtung kÖnnte auf eine onkogenbedingte, unterschiedliche Expression des Glukosetransportproteins hinweisen.

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“…So ist zum Beispiel der Aufnahmemechanismus von Gallium immer noch umstritten. Hier wird die Aufnahme eines Transferrin-Gallium-Komplexes kontrovers diskutiert (8). Em weiterer Nachteil liegt in der Tatsache, da1 diese Techniken nur zweidimensionale Darstellungen und keine absoluten Messungen ermoglichen.…”

unclassified

PET in der Tumordiagnostik im Kopf-Hals-Bereich

Reißer

Haberkorn²,

Strauss

1991

Laryngo-Rhino-Otol

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PET, a new method in nuclear medicine, allows the in vivo measurement of tumor metabolism and tumor perfusion. Absolute and standardized PET data can be used for comparative examinations before, during and after therapy. It thereby is possible to assess very early the efficacy of a therapy and also to change the therapeutic scheme. Furthermore PET studies with multiple parameters allow the evaluation of the biological behaviour of the tumor and yield information that is relevant for prognosis.

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The relationship between 67Ga accumulation and ATP metabolism in tumor cells in vitro

Cited by 7 publications

References 15 publications

Molecular Imaging of Pulmonary Inflammation and Infection

Molecular Imaging of Pulmonary Inflammation and Infection

Proliferation und Fluordeoxyglukoseaufnahme bei HNO-Tumoren

PET in der Tumordiagnostik im Kopf-Hals-Bereich

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