The relationship between adipokine levels and bone mass—A systematic review

Mangion, Darren; Pace, Nikolai Paul; Formosa, Melissa M.

doi:10.1002/edm2.408

Cited by 15 publications

(11 citation statements)

References 46 publications

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“…However, it is typically the lean body mass that has a positive effect on bone health, rather than fat mass (Ho-Pham et al, 2014, Nguyen et al, 2020). Nevertheless, the connection between skull bone thickness and adiposity might involve the effects of adipokines (i.e., cytokines produced by the adipocytes) on bone mass (Mangion et al 2023) and further studies are needed to elucidate this finding.…”

Section: Discussionmentioning

confidence: 99%

Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head

Kalc,

Hoffstaedter,

Luders

et al. 2024

Preprint

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Bones and brain are intricately connected and scientific interest in their interaction is growing. This has become particularly evident in the framework of clinical applications for various medical conditions, such as obesity and osteoporosis. The adverse effects of obesity on brain health have long been recognised, but few brain imaging studies provide sophisticated body composition measures. Here we propose to extract the following bone- and adiposity-related measures from T1-weighted MR images of the head: an approximation of skull bone mineral density (BMD), skull bone thickness, and two approximations of subcutaneous fat (i.e., the intensity and thickness of soft non-brain head tissue). The reliability and validity of these four distinct measures were tested in two large-scale databases, the UK Biobank and OASIS-3. The measures pertaining to skull BMD, skull bone thickness, and intensity-based adiposity proxy proved to be reliable (r=.93/.83/.74, p<.001) and valid, with high correlations to DXA-derived head BMD values (rho=.70, p<.001) and MRI-derived abdominal subcutaneous adipose volume (rho=.62, p<.001). Thickness-based adiposity proxy had only a low retest reliability (r=.58, p<.001). The outcomes of this study constitute an important step towards extracting relevant non-brain features from available brain scans.

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Section: Discussionmentioning

confidence: 99%

Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head

Kalc,

Hoffstaedter,

Luders

et al. 2024

Preprint

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show abstract

“…As an underlying mechanism, in vitro studies suggested that leptin exerts direct osteogenic effects mediated by its receptors in osteoblasts and osteoclasts [64][65][66] . Published data regarding the effects of leptin on bone parameters are however contradictory showing both anti-osteogenic as well as anabolic effects on bone formation (for reviews see 67,68 ). In the present study, partial correlation analyses revealed a significant negative association between leptin and BMC in men after adjusting for weight (with BMD and T-Score showing a trend towards significance) confirming a sex-specific effect of this hormone.…”

Section: Discussionmentioning

confidence: 99%

Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue

Walowski

Enderlé

Braun

et al. 2023

Sci Rep

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Lower bone mass in older adults may be mediated by the endocrine crosstalk between muscle, adipose tissue and bone. In 150 community-dwelling adults (59–86 years, BMI 17–37 kg/m2; 58.7% female), skeletal muscle mass index, adipose tissue and fat mass index (FMI) were determined. Levels of myokines, adipokines, osteokines, inflammation markers and insulin were measured as potential determinants of bone mineral content (BMC) and density (BMD). FMI was negatively associated with BMC and BMD after adjustment for mechanical loading effects of body weight (r-values between −0.37 and −0.71, all p < 0.05). Higher FMI was associated with higher leptin levels in both sexes, with higher hsCRP in women and with lower adiponectin levels in men. In addition to weight and FMI, sclerostin, osteocalcin, leptin × sex and adiponectin were independent predictors of BMC in a stepwise multiple regression analysis. Muscle mass, but not myokines, showed positive correlations with bone parameters that were weakened after adjusting for body weight (r-values between 0.27 and 0.58, all p < 0.01). Whereas the anabolic effect of muscle mass on bone in older adults may be partly explained by mechanical loading, the adverse effect of obesity on bone is possibly mediated by low-grade inflammation, higher leptin and lower adiponectin levels.

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“…Also, bone metabolism and other effects are regulated by adipokines, whose levels increase or decrease in response to exercise [66 ], and the main effects of adipokines on the skeletal system are shown in Figure 2. Leptin's ability to regulate the expression of the receptor activator of nuclear factor KB ligand (RANKL) and neuropeptides in the hypothalamus and induce activation of the sympathetic nervous system gives it the ability to modulate bone formation [3,67]. The ratio of RANKL to osteoprotegerin (OPG), a substance secreted by osteoblasts, is important in bone remodelling [20].…”

Section: Skeletal Systemmentioning

confidence: 99%

“…In addition to their effects on metabolic regulation, increasing attention is being paid to the systemic effects of adipokines on the body. These include the impact on whole systems, such as the muscular, skeletal, immune, and cardiovascular systems, and on processes like spermatogenesis, insulin resistance, and tumorigenesis [3,4].…”

Section: Introductionmentioning

confidence: 99%

Interaction between Selected Adipokines and Musculoskeletal and Cardiovascular Systems: A Review of Current Knowledge

Sierawska,

Sawczuk

2023

IJMS

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Adipokines are substances secreted by adipose tissue that are receiving increasing attention. The approach to adipose tissue has changed in recent years, and it is no longer looked at as just a storage organ but its secretion and how it influences systems in the human body are also looked at. The role of adipokine seems crucial in developing future therapies for pathologies of selected systems. In this study, we look at selected adipokines, leptin, adiponectin, chemerin, resistin, omentin-1, nesfatin, irisin-1, visfatin, apelin, vaspin, heparin-binding EGF-like growth factor (HB-EGF), and TGF-β2, and how they affect systems in the human body related to physical activity such as the musculoskeletal and cardiovascular systems.

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The relationship between adipokine levels and bone mass—A systematic review

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 15 publications

References 46 publications

Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head

Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head

Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue

Interaction between Selected Adipokines and Musculoskeletal and Cardiovascular Systems: A Review of Current Knowledge

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